Specific recognitions of multivalent cyclotriphosphazene derivatives in sensing, imaging, theranostics, and biomimetic catalysis

Phosphorus–nitrogen compounds: part 68. Synthesis, characterization, stereogenism, photophysical and bioactivity studies of novel unsymmetrical dispiro(N/N)cyclotriphosphazenes with carbazolyl and 4-chlorobenzyl pendant arms

“…For instance, they act as sensors for the detection of metal ions and biochemicals. 27 Nowadays, the design of new phosphazenes with significant biological activities becomes very crucial due to resistant pathogens. In particular, many cyclic/polymeric phosphazenes have been found to be effective as anticancer and antibacterial agents.…”

“…29 Spermine-substituted derivatives show activity against HT-29 (Human Colon Adeno-Carcinoma), Hep-2 (Human Epidermoid Larynx Carcinoma) and Vero (African Green Monkey Kidney) cancer cells. 30 They are also used in applications such as bioimaging, delivering drugs and bioactive molecules, specific recognition, biomimetic catalysis 27 and potentially used as lubricants, 31 inflammable textile fibers, 32 membranes, 33 and electrolytes for sodium metal batteries. 34 On the other hand, the carbazole scaffold is one of the pharmacologically active planar heterocyclic rings.…”

Phosphazene Cyclomatrix Network-Based Polymer: Chemistry, Synthesis, and Applications

“…The molecular level of features is almost the same with two important features: (1) the existence of different types of functional groups and (2) the type of unique backbone structure polyphosphazenes have. These two features play an important role in cyclomatrix-type polyphosphazene chemistry, as the targeted number of special functional groups on the side and backbone structure of polyphosphazenes of phosphorus and nitrogen groups is alternatingly arranged to make them highly demanded polymeric species. − Based on this discussion, a very wide classification of polyphosphazene applications due to their intrinsic structural and functional group tendencies is shown in Figure . It obviously highlights that novel polymeric design and fabrication of polyphosphazenes has applications in membrane and controlled surfaces, biomedical applications, semiconductors, energy conversion materials, storage materials, as well as high performance and fire-resistant elastomers. − It is a difficult task to study the broad range of applications of polyphosphazenes.…”

Gold(i) metallocyclophosphazenes with antibacterial potency and antitumor efficacy. Synergistic antibacterial action of a heterometallic gold and silver-cyclophosphazene

“…Specifically, cyclotriphosphazene (hexachlorocyclotriphosphazene, N 3 P 3 Cl 6 ), a six-membered ring system, represents an interesting biocompatible platform to develop six branches in 3D space to form, in turn, micelles or vesicles, dendrimers and networks such as hydrogels or microspheres. Over the last few years, cyclotriphosphazenes (CPZs) have been developed in several pharmacological domains 48,58 and the use of dendrimers in general and dendrimers based on the cyclotriphosphazene core in particular has been said to represent a new strategy in nanomedicine. Besides, both PPZs and CPZs can be used as scaffolds for the design and construction of a variety of ligands, [59][60][61] to coordinate to metallic drugs.…”