Specific Stroma in the Cortex and Medulla of the Ovary. Cell Types and Vascular Supply in Relation to Follicular Apparatus and Ovulation

Reeves, Guillermo

doi:10.1097/00006254-197203000-00016

Cited by 20 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tightly packed fibrous cells are a hallmark of cortex-specific stroma (14,15), and follicular density is significantly lower in cortical tissue that lacks this type of stroma. Moreover, cortical tissue with fibrosis and concomitant loss of cortex-specific stroma was specific to histologic findings associated with reduced follicular density in cortex from ovaries with endometriomas.…”

Section: Discussionmentioning

confidence: 99%

“…Ovarian cortex is composed of ovarian surface epithelial cells, a zone of hypocellular connective tissue (tunica albuginea), and an area of cortex-specific stroma with early follicles in a layered structure (14,15). Cortex-specific stroma was made up of tightly bound fascicles, identified as a strip of strongly hematoxylin and eosin-stained cells due to increased cellular density at the border of the corticomedullary junction (14), as illustrated in Figure 1A. The presence or absence of these belt-like structures was recorded.…”

Section: Evaluation Of the Microscopic Structure Of Ovarian Cortexmentioning

confidence: 99%

“…The presence or absence of these belt-like structures was recorded. Areas containing advanced follicular structures, such as antral follicles, corpus luteum and corpus albicans, and edematous stroma with spiral vessels or large arterioles were considered as medullar regions (14,15).…”

Section: Evaluation Of the Microscopic Structure Of Ovarian Cortexmentioning

confidence: 99%

See 2 more Smart Citations

Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis

Kitajima

Defrère

Dolmans

et al. 2011

Fertility and Sterility

234

138

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Evaluation Of the Microscopic Structure Of Ovarian Cortexmentioning

confidence: 99%

See 1 more Smart Citation

Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis

Kitajima

Defrère

Dolmans

et al. 2011

Fertility and Sterility

234

138

View full text Add to dashboard Cite

“…There is better evidence for a comparable conversion into macrophage like cells, both in prenatal (20) and postnatal (61) human ovaries and in those of lower vertebrates (18,23). General accounts of the architecture and form changes of the ovarian stroma have been given by several authors (4,7,12,16,41,46,47). from 2 weeks to 15 years, comprising 17 aged 2 weeks to 3 months, 15 from the rest of the first year, 7 from the second year, 8 aged 2-5, 15 aged 5-10 and 6 aged 10-15, furnishing bilateral pairs in seven only.…”

Section: Introductionmentioning

confidence: 99%

Postnatal Formation of Ovarian Stroma and Its Relation to Ovarian Pathology

Hughesdon

1978

International Journal of Gynecology & Obstetrics

View full text Add to dashboard Cite

Ovarian development was studied in 113 patients ranging from birth to 15 years of age. After a short pause the ovary becomes highly active during the first year, subsides slowly to a trough between ages 3 and 5 and then resumes activity. During the early activity, central ripening follicles and their associated edema expand the ovary and then hold the ground gained by the progressive conversion during atresia of theca and some granulosa into medullary stroma. This later becomes amorphous and reduced in quantity. Cortical stroma forms separately and concurrently by proliferation of the interfollicular mesenchyme to form a lattice. Externally this matures to the tunica and internally anchors some ripening follicles to contribute retrogressed theca to its deeper layers. Cellular ovarian stroma probably develops as a proliferative response of loose ovarian mesenchyme to stretch, and so forms round individual ripening follicles and round the ovary as a whole stretched by the follicular complement and its associated edema. At both sites, therefore, its formation is dependent on the follicular mechanism. This explains the stromal poverty of dysgenetic and related ovaries and the stromal excess of Stein‐Leventhal ovaries, while the direct follicular ancestry of medullary and some deep cortical stroma may explain the proneness of these sites to develop lutein foci and tumors of specifically gonadal morphology. A note is added on “Pflüger's tubes,” which furnish a little cortical stroma and show disturbed development along with that of the ovary in prematurity, Turner's syndrome and mongolism.

show abstract

“…Blood supply to the ovaries is an end artery system [6], so, narrowing and/or obstruction of blood vessels will lead to a local ischemia and local destruction of normal ovarian cortex with loss of primordial follicles.…”

Section: Mechanism Of Chemotherapymentioning

confidence: 99%

The Effects of Cancer Therapy on Women’s Fertility: What do We Know Now?

2016

View full text Add to dashboard Cite

Due to the improvements of cancer treatment, the survival rate of cancer increased over the last decades. One of the detrimental side effects of cytotoxic treatment is the impairment or loss of fertility. Having a family is one of the important aspects for long-time survivors. The impact of gynecologic cancer on fertility depends on the site and kind of the cancer disease, the oncologic therapeutic regimen and additional the age of the patient. In cancer of the internal genital organs, fertility-preserving surgery techniques should be used, if possible. In case, that cytotoxic treatment has to be applied, fertility preservation techniques should be implemented into the oncologic treatment.

show abstract

Specific Stroma in the Cortex and Medulla of the Ovary. Cell Types and Vascular Supply in Relation to Follicular Apparatus and Ovulation

Cited by 20 publications

References 0 publications

Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis

Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis

Postnatal Formation of Ovarian Stroma and Its Relation to Ovarian Pathology

The Effects of Cancer Therapy on Women’s Fertility: What do We Know Now?

Contact Info

Product

Resources

About