Specific Suppression of Allograft Rejection by Soluble Class I Antigen and Complexes With Monoclonal Antibody

Sumimoto, Ryo; Kamada, Nanao

doi:10.1097/00007890-199010000-00029

Cited by 134 publications

(62 citation statements)

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“…First in pigs (104) and then in rodents (88,113,114), Calne, Zimmermann, and Kamada-and subsequently others (115, 116}-showed that the tolerization extended to other donor organs transplanted at the same time or later. Caine's hypothesis that soluble MHC class I antigen secreted by the hepatocytes was responsible (104,113,(117)(118)(119)(120) was weakened when Corry et aI. (121) and Russell et aI.…”

Section: Discussionmentioning

confidence: 99%

“…There has been little direct experimental support for this position in whole animals. Although an im· munosuppressive effect of serum was ascribed by Kamada et al (113) to soluble class I antigens, purified antigens in subsequent studies have had minimal (119) or no immunosuppressive or tolerogenic action (] 30, 131). Finally, results from studies in mice (4) including those with "knocked-out" class I genes (132) have further eroded the hypothesis.…”

Section: Discussionmentioning

confidence: 99%

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Variable Chimerism, Graft-Versus-Host Disease, and Tolerance After Different Kinds of Cell and Whole Organ Transplantation From Lewis to Brown Norway Rats

et al. 1995

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Variable Chimerism, Graft-Versus-Host Disease, and Tolerance After Different Kinds of Cell and Whole Organ Transplantation From Lewis to Brown Norway Rats

et al. 1995

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“…28 It also prolonged survival of cardiac allografts, especially when it was complexed with an anti-MHC antibody. 29 However, it is not believed to be the principal means of liver allograft tolerance because some experiments showed it was ineffective in prolonging graft survival, 26 and tolerance still occurred when MHC class I-deficient livers were transplanted. 30 More recently, it has been proposed that the liver may also inhibit rejection through the particular characteristics of its unique vascular architecture and the immunomodulatory activity of hepatocytes.…”

Section: Postulated Immune Mechanisms Of Liver Allograft Tolerancementioning

confidence: 99%

Immune activation is required for the induction of liver allograft tolerance: Implications for immunosuppressive therapy

Bishop

McCaughan

2001

Liver Transpl

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Liver transplants in many animal models are unusual because often they are not rejected even when transplanted across complete major histocompatibility complex barriers without immunosuppression. Their paradoxical behavior is even more obvious when the immune mechanism of acceptance is examined. Instead of acceptance resulting from a lack of immune response to the graft, the opposite occurs, and there is an unusual extensive increase in immune activation in acceptance compared with rejection. This abnormal extensive immune activation is driven by

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“…Several investigations using KCl-extractions containing soluble MHC molecules provided evidence for an allospecific T cell suppressive effect (15.22.23]. Kamada demonstrated a slight but .significant suppression by continuous infusion of purified MHC class 1 molecules in the rat heart allograft model [16]. whereas others found no effect on graft acceptance using a bulk injection before or after transplantation [24].…”

Section: Disclssionmentioning

confidence: 99%

Interaction of papain-digested HLA class I molecules with human alloreactive cytotoxic T lymphocytes (CTL)

Hausmann

Zavazava

Steinmann

et al. 1993

Clinical and Experimental Immunology

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SUMMARYAcme immunologicai rejection events of iransplanted allogeneic organs are strongly dependent on T eell reactivity against foreign MHC products. The recognition requirements of alloreactive cytotoxic T cells arc of particular interest for finding approaches lo modulating alloreactivily. The role of the allogeneic MHC molecule itself and/or an associated pcptide in the interaction with the T cell reeeptor is still, however, unclear. Our sliidics have focused on the interactions of papain-digesled HLA class 1 molecules wilh alloreactive CD8 • CTL. These polypeptides, consisting of the polymorphic x\ and 3:2 and the monomorphic ix?> domains, were used in both soluble and immobilized form to study their functional effects on anti-HLA-A2 reactive CTL, Purified polypeptides were of molecular mass 32 34 kD, HLA-A2 polypeptides (0-55 /(g/ml) in soluble form induced half-maximai reduction of CTL cytotoxicity. These concentrations were quantitatively comparable to the cfTective doses of intact HLA class I molecules, which contain the hydrophobic transmembrane domain and theintracytoplasmic tail. In addition, specific activation requirements of these CTL were investigated in a serine eslerasc release as-say. Maximal degranulation was observed after 2 h of antigen contact. Purified HLA class I molecules allospecificalty activated the anti-HLA-A2 CTL to degranulate serine esterase, when immobilized on plastic microtitre plates. Thus, polypeptides containing the polymorphic y\ and «2 domains of human class I molecule.s potentially modulate the cytotoxic T cell response. This might have implications for the reduction or prevention of allograft rejection in recipients of foreign organs.

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Specific Suppression of Allograft Rejection by Soluble Class I Antigen and Complexes With Monoclonal Antibody

Cited by 134 publications

References 0 publications

Variable Chimerism, Graft-Versus-Host Disease, and Tolerance After Different Kinds of Cell and Whole Organ Transplantation From Lewis to Brown Norway Rats

Variable Chimerism, Graft-Versus-Host Disease, and Tolerance After Different Kinds of Cell and Whole Organ Transplantation From Lewis to Brown Norway Rats

Immune activation is required for the induction of liver allograft tolerance: Implications for immunosuppressive therapy

Interaction of papain-digested HLA class I molecules with human alloreactive cytotoxic T lymphocytes (CTL)

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