Specific treatment for acute pancreatitis

Wen, Li; Javed, Muhammad Ahsan; Altaf, Kiran; Szatmary, Peter

doi:10.1002/9781118924907.ch9

Cited by 1 publication

(2 citation statements)

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“…Oxidative stress of neutrophils activated during the inflammatory response to acinar injury may cause the further spread of local and systemic inflammation 5 , 14 . Thus, NF-κB activation and oxidative stress are potential therapeutic targets for AP 5 , 15 .…”

Section: Introductionmentioning

confidence: 99%

“…These plant extracts show good pharmacological effects and greatly alleviate the symptoms of AP. However, the preparation and treatment processes of these drugs are complex, and their clinical applications remain limited by the lipid solubility of the drug and other pharmacokinetic/pharmacodynamics challenges 5 , 15 . Alternatively, nanomaterials with enzymatic catalytic properties (nanozyme) have been developed in recent years 20 , 21 .…”

Section: Introductionmentioning

confidence: 99%

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Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway

Xie¹,

Zhao²,

Gao³

et al. 2021

Theranostics

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Rationale: Acute pancreatitis (AP) is a serious acute condition affecting the abdomen and shows high morbidity and mortality rates. Its global incidence has increased in recent years. Inflammation and oxidative stress are potential therapeutic targets for AP. This study was conducted to investigate the intrinsic anti-oxidative and anti-inflammatory effects of Prussian blue nanozyme (PBzyme) on AP, along with its underlying mechanism. Methods: Prussian blue nanozymes were prepared by polyvinylpyrrolidone modification method. The effect of PBzyme on inhibiting inflammation and scavenging reactive oxygen species was verified at the cellular level. The efficacy and mechanism of PBzyme for prophylactically treating AP were evaluated using the following methods: serum testing in vivo , histological scoring following hematoxylin and eosin staining, terminal deoxynucleotidyl transferase dUTP nick end labeling fluorescence staining, polymerase chain reaction array, Kyoto Encyclopedia of Genes and Genomes analysis and Western blotting analysis. Results: The synthetic PBzyme showed potent anti-oxidative and anti-inflammatory effects in reducing oxidative stress and alleviating inflammation both in vitro and in vivo in the prophylactic treatment of AP. The prophylactic therapeutic efficacy of PBzyme on AP may involve inhibition of the toll-like receptor/nuclear factor-κB signaling pathway and reactive oxygen species scavenging. Conclusion: The single-component, gram-level mass production, stable intrinsic biological activity, biosafety, and good therapeutic efficacy suggest the potential of PBzyme in the preventive treatment of AP. This study provides a foundation for the clinical application of PBzyme.

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Section: Introductionmentioning

confidence: 99%