“…This editorial will present the latest specifications of all COMBINE standards, and this special issue highlights updates over the last year, namely the releases of the following specifications: OMEX Metadata Version 1.2, SED-ML Level 1 Version 4, SBOL Visual 2.3 and 3.0. Special issues on COMBINE standards have been published since 2016, and earlier editions [ 3 ], [ 4 ], [ 5 ], [ 6 ], [ 7 ] provide updates for the years 2015–2020.…”