Specificity and efficiency of tamoxifen-mediated Cre induction is equivalent regardless of age

Kellogg, Collyn M.; Pham, Kevin; Ko, Sunghwan; Cox, Jillian E.J.; Machalinski, Adeline H.; Stout, Michael B.; Sharpe, Amanda L.; Beckstead, Michael J.; Chucair-Elliott, Ana J.; Ocañas, Sarah R.; Freeman, Willard M.

doi:10.1016/j.isci.2023.108413

Cited by 1 publication

(1 citation statement)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over the years, various advancements of the original recombination system have emerged to achieve even finer spatiotemporal comprehension (Shcholok and Eftekharpour, 2023 ). These include the tamoxifen-inducible Cre-ER T2 system (Belteki et al, 2005 ; Heldt and Ressler, 2011 ; Hui et al, 2022 ; Kellogg et al, 2023 ), photoactivatable Cre recombinases (Yoshimi et al, 2021 ; Li et al, 2022 ), Cre/Dre dual recombinase systems (Kouvaros et al, 2023 ) and split Cre systems (Khoo et al, 2020 ; Kim et al, 2021 ), among others. Some of these configurations are of extreme help to easily explore the time and the space, inducing the pathological insult within cell types at various embryonic and postnatal timepoints with high specificity.…”

Section: Exploring Space and Time: Novel Insights From Animal Modelsmentioning

confidence: 99%

Need of orthogonal approaches in neurological disease modeling in mouse

Bossini,

Sessa

2024

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Over the years, advancements in modeling neurological diseases have revealed innovative strategies aimed at gaining deeper insights and developing more effective treatments for these complex conditions. However, these progresses have recently been overshadowed by an increasing number of failures in clinical trials, raising doubts about the reliability and translatability of this type of disease modeling. This mini-review does not aim to provide a comprehensive overview of the current state-of-the-art in disease mouse modeling. Instead, it offers a brief excursus over some recent approaches in modeling neurological diseases to pinpoint a few intriguing strategies applied in the field that may serve as sources of inspiration for improving currently available animal models. In particular, we aim to guide the reader toward the potential success of adopting a more orthogonal approach in the study of human diseases.

show abstract