Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour

Wong, Newton A C S; Shelley-Fraser, Golda

doi:10.1111/j.1365-2559.2010.03622.x

Cited by 36 publications

(46 citation statements)

References 24 publications

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“…Hemminger ve ark. 'nın [9] yaptığı çalışmada ise 117 GİST dışı yumuşak doku tümörü olgusunun yalnızca 3 tanesinde (Desmoplastik Melanoma, malign periferik sinir kılıfı tümörü ve Schwannoma olguları) DOG1 pozitifliği saptanmıştır. Sinovyal sarkom, düşük dereceli fibromiksoid sarkom, Leiomyosarkom, Perinöroma, Nörofibroma, Anjiosarkoma olgularında DOG1 negatif bulunmuştur [8].…”

Section: Discussionunclassified

“…Sonuç olarak farklı çalışmalarda GİST ayırıcı tanısında yer alan Sinovial sarkom, Leiomyosarkom, Fibrosarkom, Ewing sarkomu, malign periferik sinir kılıfı tümörü, Glomus tümörü, Peritoneal leiomyomatöz lezyonlar, Anjiosarkom, Schwannom ve Desmoplastik melanomlarda %0,3-2,5 oranında fokal ve soluk DOG1 ekspresyonundan bahsedilmektedir [5,6,[8][9][10]. Bizim çalışmamızda, daha önce yapılan çalışmalara benzer şekilde Nörofibroma, Desmoid tümör ve Dermatofibrosarkoma protuberans olgularında DOG1 ekspresyonu saptanmamış, DOG1'in bu tümörlerde tanısal değerinin olmadığı anlaşılmıştır.…”

Section: Discussionunclassified

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Fibroblastik/myofibroblastik benign ve lokal agresif neoplaziler ve nörofibromalarda DOG1 ekspresyon profili

Ersöz¹,

Kankaya²,

Kiremitci³

et al. 2014

CMJ

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Amaç. Gastrointestinal stromal tümörlerde (GİST) spesifik olarak ekspresyon gösteren ve kalsiyum bağımlı klorid kanalı olarak bilinen DOG1, gastrointestinal stromal tümörlerin diğer sarkomlardan ayrımında kullanılan tanısal bir belirteçtir. Çeşitli araştırmalarda Gastrointestinal stromal tümor dışı mezenşimal tümörlerde değişen oranda DOG1 ekspresyonu bildirilmiştir. AbstractAim. DOG1 is a calcium-dependent chlorid channel, that shows specific expression in Gastrointestinal stromal tumors (GIST) can be used in differential diagnosis of these tumors with other soft tissue sarcomas. In several studies, DOG1 expression has been reported in varying proportions in Non-GIST mesenchymal tumors. In this study, we aimed to find the DOG1 expression profile in Nodular fasciit, Neurofibroma, Desmoid tumors and Dermatofibrosarcoma protuberans. Method. Nodular fasciit (n=8), Neurofibroma (n=8), Desmoid tumors (n=8) and Dermatofibrosarcoma protuberans (n=8) cases, diagnosed in Ankara University, Faculty of Medicine, Department of Pathology between 2005-2012, were included in this study. Results. Focal and pale DOG1 reactivity was seen only in one case of Nodular fasciit (1/8) whereas the remainig cases were negative with DOG1. Conclusion. DOG1 has no diagnostic value in benign and locally aggressive fibroblastic/myofibroblastic neoplasms and neurofibromas.

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Section: Discussionunclassified

Fibroblastik/myofibroblastik benign ve lokal agresif neoplaziler ve nörofibromalarda DOG1 ekspresyon profili

Ersöz¹,

Kankaya²,

Kiremitci³

et al. 2014

CMJ

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“…In immunohistochemistry, DOG1 has been considered a specific marker of GIST; however, glomus tumors are focally and weakly positive for DOG1 [16]. Meanwhile, another report stated that glomus tumor is negative for DOG1 [17].…”

Section: Discussionmentioning

confidence: 99%

Glomus tumor of the esophagus

et al. 2012

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Here we report a case of primary glomus tumor of the esophagus, which is extremely rare, and review the corresponding literature. A 69-year-old man underwent screening endoscopy during a medical checkup and a submucosal tumor was incidentally found in the midthoracic esophagus. Endoscopic ultrasonography revealed that the tumor originated from the muscle layer of the esophagus. Computed tomography and 18 F-fluorodeoxyglucose positron emission tomography revealed neither lymphadenopathy nor distant metastasis. Endoscopic ultrasonography-guided fine needle aspiration biopsy indicated epithelioid mesenchymal tumor. Immunohistochemically, the tumor cells were positive for alpha smooth muscle actin, and focally positive for Discovered on GIST1 but negative for c-kit and protein kinase C theta, suggesting that the lesion was a KIT-negative epithelioid gastrointestinal stromal tumor or glomus tumor. The tumor was successfully enucleated through right thoracotomy. Pathological examination confirmed that the tumor was a glomus tumor of the esophagus. The patient remains healthy without any recurrence to date one year after surgery.

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“…Activation-loop phosphorylation of PKCθ, a marker of PKC-theta activity [48], was also detected at high levels in GIST lysates compared to Jurkat cell controls [47]. Not only is PKCθ strongly expressed and catalytically competent in GISTs, but a number of groups have demonstrated its utility as a diagnostic marker [49][50][51].…”

Section: Gistmentioning

confidence: 99%

Targeting protein kinase C in sarcoma

Martín-Liberal

Cameron

Claus

et al. 2014

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour

Abstract: Compared with CD117, DOG1 (using the K9 antibody) is a more specific marker, whereas PKC theta (using the clone 27 antibody) is a considerably less specific immunohistochemical marker for GIST.

Cited by 36 publications

References 24 publications

Fibroblastik/myofibroblastik benign ve lokal agresif neoplaziler ve nörofibromalarda DOG1 ekspresyon profili

Fibroblastik/myofibroblastik benign ve lokal agresif neoplaziler ve nörofibromalarda DOG1 ekspresyon profili

Glomus tumor of the esophagus

Targeting protein kinase C in sarcoma

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