Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarction

Roberts, Robert; Gowda, Kempe; Ludbrook, Philip A.; Sobel, Burton E.

doi:10.1016/0002-9149(75)90890-5

Cited by 275 publications

(42 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 1996, van der Ween and Willebrands (10 ) showed that MBCK is a highly specific marker of myocardial infarction. The CK content of myocardial tissue was shown to be ϳ15% MB and the remainder MMCK (11 ). MBCK was in the right place at the right time.…”

Section: Historical Perspectivementioning

confidence: 92%

Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present

et al. 2004

Self Cite

View full text Add to dashboard Cite

Editor’s Note: With great pleasure and anticipation in recognition of Clinical Chemistry’s 50th anniversary, I have been able to arm-twist four talented scientists to document their impressive marks on the science of diagnostics in the field of cardiac biomarkers and detection of myocardial infarction. Their exciting discoveries and applications have dramatically influenced the fields of laboratory medicine and cardiology and have greatly influenced the care and management of thousands of patients suffering from coronary artery disease leading to acute myocardial infarction. As a matter of historical record, I owe a great deal of thanks to each one of the coauthors of this special report because each one has personally influenced my scientific career. I met Dr. Rosalki, during my postdoctoral training, at a national AACC meeting, where he kindly answered my numerous queries regarding creatine kinase enzymology and muscle physiology. Dr. Roberts, while serving as Director of the Coronary Care Unit at Washington University in St. Louis, generously allowed this fledgling fellow into his laboratory and shared many of his clinical and experimental findings with me. Dr. Katus, whom I first met at a scientific meeting sponsored by Boehringer Mannheim in 1986 in Bavaria, where I first became fascinated with cardiac troponin T, has remained a friend and colleague. Lastly, Dr. Ladenson, who as mentor, scientific colleague, and close friend remains ultimately responsible for both my professional growth as a clinical chemist (he was my postdoctoral fellowship advisor) and for stimulating and encouraging my goals and aspirations in the field of cardiac biomarkers. With the descriptions of the ground-breaking science described below, I am extremely excited and optimistic that the future of cardiac biomarkers is secure and open to new discoveries by the Rosalkis, Robertses, Katuses, and Ladensons of the future. —Fred Apple

show abstract

Section: Historical Perspectivementioning

confidence: 92%

Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present

et al. 2004

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been claimed recently that the isoenzymes of creatine kinase represent a higher degree of specificity (8). A similar high degree of specificity has been attributed to arginase (7) and glycogen phosphorylase (4) in the early differential diagnosis of myocardial infarction.…”

Section: Introductionmentioning

confidence: 93%

Serum Adenylate Kinase Activity in the Early Phase of Acute Myocardial Infarction

Frithz

Ericsson

Ronquist

1976

Upsala Journal of Medical Sciences

View full text Add to dashboard Cite

Elevated adenylate kinase activities in serum and urine have been studied among patients suffering from myocardial infarction. 71% of the patients had clearly increased activities in serum already on admission to the hospital, i.e. about 12 hours after onset of symptoms and patients was 45%. A maximum peak value of the activity in serum was seen at 6 hours after admission to the hospital, i.e. about 12 hrs after onset of symptoms and the elevated enzyme activity value persisted for at least 12 hours after admission. The patients with the elevated adenylate kinase activity in serum were arbitrarily divided into three groups as regards activity. It was shown that the difference in activity of ASAT as well as LD of the high and low activity group was significant @<0.01). No such difference was established between these groups for ALAT, usually not being considered as a reliable test enzyme for myocardial infarction.

show abstract

“…Despite differing isoenzyme assay techniques, the sensitivity and specificity of an elevated serum CK-MB in the diagnosis of myocardial infarction is well in excess of 90% (Konttinen et al, 1973;Roberts et al, 1975). This high specificity has been attributed to the finding that cardiac muscle is the only normal human tissue containing sufficient amounts of CK-MB to account for appreciable elevations of CK-MB activity in the serum (Roberts et al, 1975). Elevated serum levels of CK accompanied by an MB fraction in excess of 2-496 has generally been accepted as an indication of myocardial damage or infarction.…”

Section: Introductionmentioning

confidence: 99%

Elevated CK‐MB and CK‐BB in serum and tumor homogenate of a patient with lung cancer

Lee

Bach

Horton

et al. 1985

Clinical Cardiology

View full text Add to dashboard Cite

Summary: Elevated serum levels of creatine kinase (CK) were found in a patient with small-(oat) cell carcinoma of the lung. Fractionation of the enzyme showed markedly elevated CK-MB and CK-BB isoenzymes. Clinical and subsequent pathological examination showed no evidence of infarction, inflammation, or tumor involvement of the heart; however, analysis of tumor tissue for CK showed predominance of CK-MB and CK-BB isoenzymes, thus implicating tumor as the source of the circulating levels of CK-MB and CK-BB. Our case is the first to document CK-MB from neoplastic tissue homogenates, and illustrates that markedly elevated circulating levels of CK-MB, or increased levels of CK-MB in combination with CK-BB may point away from a myocardial source, and toward the existence of a malignancy.

show abstract

Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarction

Cited by 275 publications

References 18 publications

Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present

Cardiac Biomarkers for Detection of Myocardial Infarction: Perspectives from Past to Present

Serum Adenylate Kinase Activity in the Early Phase of Acute Myocardial Infarction

Elevated CK‐MB and CK‐BB in serum and tumor homogenate of a patient with lung cancer

Contact Info

Product

Resources

About