Specificity of IgA class anti-yersinia antibodies in yersinia arthritis

The IgA and IgG antibody response to plasmid-encoded outer membrane proteins was studied in 59 patients with yersinia-associated spondylarthropathy during 15 months of follow-up. Initially, all patients had specific IgA and IgG antibodies to the 36 and 46 kDa and 30% also to the 26 and 58 kDa released proteins, which correlated with the finding of virulent Yersinia bacilli in intestinal biopsies. IgA disappeared in 69% of untreated patients after nine months and persisted in 31% after one year. IgA disappeared within three to six months in 81% of the patients treated with antibiotics for four to six weeks and persisted in 6% after one year (p less than 0.002). IgG antibodies to the 36 and 46 kDa outer membrane proteins persisted in 80% of all patients. Disappearance of IgA was coupled with disappearance of yersinia from intestinal biopsies.

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Influence of antibiotics on IgA and IgG response and persistence ofYersinia enterocolitica in patients with yersinia-associated spondylarthropathy

Hoogkamp-Korstanje¹,

Koning²,

Heesemann

et al. 1992

Infection

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Rheumatoid Factors in Yersinia-Triggered Reactive Arthritis

Granfors¹,

Lahesmaa‐Rantala²,

Toivanen³

et al. 1988

Scandinavian Journal of Rheumatology

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Specificity of IgA class anti-yersinia antibodies in yersinia arthritis

Cited by 2 publications

References 13 publications

Influence of antibiotics on IgA and IgG response and persistence ofYersinia enterocolitica in patients with yersinia-associated spondylarthropathy

Influence of antibiotics on IgA and IgG response and persistence ofYersinia enterocolitica in patients with yersinia-associated spondylarthropathy

Rheumatoid Factors in Yersinia-Triggered Reactive Arthritis

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