Specificity of Protein Carbonylation and Its Relevance in Aging

Cabiscol, Elisa; Tamarit, Jordi; Ros, Joaquim

doi:10.1002/9781119374947.ch14

Cited by 4 publications

(5 citation statements)

References 183 publications

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“…Exposure of RS to a protein leads to modifications of amino acid side chains by protein oxidation. These changes can prevent protein function or make the protein increasingly susceptible to proteolytic degradation by the proteosome, a catalytic ATP-independent enzyme complex designed to degrade proteins tagged by ubiquitin [169]. This is part of the cell's evolved methods for self-preservation by removing damaged cellular components.…”

Section: Proteinsmentioning

confidence: 99%

Electrocatalytic generation of reactive species and implications in microbial inactivation

Nichols

Ozoemena

Chen

2022

Chinese Journal of Catalysis

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Section: Proteinsmentioning

confidence: 99%

Electrocatalytic generation of reactive species and implications in microbial inactivation

Nichols

Ozoemena

Chen

2022

Chinese Journal of Catalysis

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“…50 ROS are able to damage the cell membrane and disrupt essential membrane-bound proteins, 51 in addition to creating single stranded or double stranded breaks in DNA, rendering it unable to be replicated. 52,53 The antimicrobial activity of ROS varies between environments and experiments; therefore the exact mechanism of action is not fully understood, nor agreed upon. 54 Macrophages of mammalian immune systems rely heavily upon ROS to eliminate pathogens from the body.…”

Section: Titanium Dioxide Nanoparticlesmentioning

confidence: 99%

Inorganic nanoparticles engineered to attack bacteria

et al. 2015

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Antibiotics were once the golden bullet to constrain infectious bacteria. However, the rapid and continuing emergence of antibiotic resistance (AR) among infectious microbial pathogens has questioned the future utility of antibiotics. This dilemma has recently fueled the marriage of the disparate fields of nanochemistry and antibiotics. Nanoparticles and other types of nanomaterials have been extensively developed for drug delivery to eukaryotic cells. However, bacteria have very different cellular architectures than eukaryotic cells.This review addresses the chemistry of nanoparticle-based antibiotic carriers, and how their technical capabilities are now being re-engineered to attack, kill, but also non-lethally manipulate the physiologies of bacteria. This review also discusses the surface functionalization of inorganic nanoparticles with small ligand molecules, polymers, and charged moieties to achieve drug loading and controllable release.

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“…Moreover, the macromolecular damage was evaluated by measuring Advanced Oxidation Protein Products (AOPP) and oxidized lipids. 15 The AOPP are currently used as markers of oxidative stress in plasma, due to the vulnerability of proteins to ROS and RNS. For instance, the oxidation of tyrosine (an amino-acid residue), leads to the formation of dityrosine, protein aggregation, fragmentation and crosslinking.…”

Section: Introductionmentioning

confidence: 99%