Specificity of psychopathology in temporal lobe epilepsy

Foran, Amie M.; Bowden, Stephen C.; Bardenhagen, Fiona J.; Cook, Mark; Meade, Catherine E.

doi:10.1016/j.yebeh.2012.12.026

Cited by 15 publications

(8 citation statements)

References 43 publications

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“…The results of this review suggest clinically significant psychiatric comorbidity in more than half the children and a third of all adults with GGE. This prevalence is higher than in the general population (Baumeister and Harter 2007 2006;Devinsky et al 1999;Foran et al 2013). Indeed, our results indicate that the relative frequency of psychiatric disorders within GGE is similar to the frequency reported from larger, epidemiological studies; anxiety and affective disorders are the most prevalent, followed by personality disorders, then schizophrenia and other psychotic disorders (Kessler et al 2009;Torgersen et al 2001;Jablensky 1997;Reich et al 1989).…”

Section: Discussionsupporting

confidence: 82%

“…In sum, there is a dearth of literature using validated measures of personality and psychopathology (McCrae and Costa Jr 1999). In the absence of strong empirical evidence or theoretically plausible explanations for the JME personality type, this hypothesis remains speculative and is reminiscent of Geschwind's controversial 'interictal personality disorder' of TLE (Benson 1991;Foran et al 2013). Janz'…”

Section: Personality Disorder and Traitsmentioning

confidence: 99%

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A Systematic Review of Psychiatric and Psychosocial Comorbidities of Genetic Generalised Epilepsies (GGE)

2016

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Psychiatric disorders and associated poor psychosocial outcomes are recognised to be a common sequelae of epilepsy. The extent to which this is true of genetic generalised epilepsies (GGE), particularly syndromes other than juvenile myoclonic epilepsy (JME) is unclear. This systematic review synthesises findings regarding psychiatric and associated comorbidities in adults and children with GGE. Systematic review yielded 34 peer-reviewed studies of psychiatric and psychosocial outcomes in adults and children with GGE. Clinically significant psychiatric comorbidity was reported in over half of all children and up to a third of all adults with GGE. There was no evidence to support the presence of personality traits specific to JME or other syndromes; rather rates mirrored community samples. A small number of studies report poor psychosocial outcomes in GGE, however the interpretation of these findings is limited by paucity of healthy comparison groups. Some evidence suggests that anti-epileptic drug polytherapy in children and seizure burden at all ages may constitute risk factors for psychopathology. Findings highlight the importance of early screening so as not to overlook early or developing symptoms of psychopathology.

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Section: Discussionsupporting

confidence: 82%

Section: Personality Disorder and Traitsmentioning

confidence: 99%

A Systematic Review of Psychiatric and Psychosocial Comorbidities of Genetic Generalised Epilepsies (GGE)

2016

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“…Our finding that IDD occurs with the same frequency in focal and generalized epilepsy is in line with recent publications. 15,16 With the Portuguese version of IDDI, 51% of the patients in tertiary epilepsy centers had IDD, and as in our study two thirds of the patients with IDD were females. 17 Our finding of 19% of patients with IDD using IDDI matched the finding by Mula et al 6 (17%).…”

Section: Discussionsupporting

confidence: 70%

The interictal dysphoric disorder in patients with epilepsy: A doubtful disorder lacking diagnostic tools

Amiri

Hansen

2015

Seizure

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With a prevalence of 19%, IDD appeared to be the commonest neuropsychiatric syndrome. The majority of the patients with IDD also had depressive and/or anxiety disorders. Quality of life, seizure control, and side effects to antiepileptic drugs were affected much more by depression or anxiety, than by IDD. The Danish version of IDDI has a poor reproducibility. The existence of IDD as a diagnostic entity is doubtful.

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“…We also found a direct relation between IQ and sluggish cognitive tempo, attention problems, aggressive behavior, and competence activities. Such a relation is expected because of the pervasive impact of intellectual underachievement on cognition, as well as on the adaptive capacity of the individual 20,21,22,23 . When categorizing the patients into normal and lowered IQ, unlike the linear correlation between IQ and psychopathology, we found that children with epilepsy with lowered IQ showed no significant difference with respect to psychopathology, when compared with epilepsy children with normal IQ.…”

Section: Discussionmentioning

confidence: 99%

Mental health of children and adolescents with epilepsy: analysis of clinical and neuropsichological aspects

Moreira

Lima

Fonseca

et al. 2014

Arq. Neuro-Psiquiatr.

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Epilepsy compromises the development of cognitive and social skills and represents a risk of psychiatric comorbidity. Objective: To compare psychopathological symptoms in children with epilepsy and in a healthy group, and to correlate the results with neuropsychological and clinical variables. Method: Forty five children with idiopathic epilepsy and sixty five healthy controls underwent neuropsychological evaluation and their caregivers replied to a psychopathology questionnaire (Child Behavior Checklist -CBCL). Results: : There were significant differences in CBCL, with poorer results showed mainly by patients with epilepsy. There was no significant association between any psychopathological symptom and disease duration or amount of antiepileptic drugs used. There was positive correlation between intelligence quocient and CBCL on items such as sluggish cognitive tempo, aggressive behavior, attention problems and activities and a negative relation between academic achievement, conduct and rule-breaking behavior. Conclusion: Children with epilepsy had the worse results in the psychopathology evaluation. Certain psychopathological variables are related to the cognitive profile, with no relation to clinical variables.Keywords: epilepsy, children, adolescent, neuropsychology, psychopathology, mental health. RESUMOA epilepsia compromete o desenvolvimento de habilidades cognitivas e sociais e representa um risco para comorbidade psiquiátrica. Objetivo: Comparar sintomas psicopatológicos em crianças com epilepsia e um grupo saudável, e correlacionar os resultados com variáveis neuropsicológicas e clínicas. Método: Quarenta e cinco crianças com epilepsia idiopática e sessenta e cinco controles saudáveis foram submetidos à avaliação neuropsicológica e seus cuidadores responderam a um questionário de psicopatologia (Child Behavior Checklist -CBCL). Resultados: Houve diferenças significativas no CBCL, com piores resultados principalmente para pacientes com epilepsia. Não houve associação significativa entre os resultados e duração da doença ou número de drogas antiepilépticas. Houve relação positiva entre quociente de inteligência e CBCL em itens como tempo cognitivo lento, comportamento agressivo, problemas de atenção e atividades e uma relação negativa entre o desempenho acadêmico e conduta e comportamento de quebras de regra. Conclusão: Crianças com epilepsia apresentaram piores resultados em psicopatologia, com certas variáveis psicopatológicas relacionadas ao perfil cognitivo, mas sem relação com variáveis clínicas.Palavras-chave: epilepsia, crianças, adolescentes, neuropsicologia, psicopatologia, saúde mental.Although the most specific characteristic of epilepsy is the epileptic seizure, the condition involves mental problems, including learning disorders, compromised quality of life and psychopathology. Such problems arise from a complex sum of factors related to ethiology, therapy, seizure per se, as well as individual and social-familiar aspects.Rates of mental disorder in children and adolescents with epi...

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Specificity of psychopathology in temporal lobe epilepsy

Cited by 15 publications

References 43 publications

A Systematic Review of Psychiatric and Psychosocial Comorbidities of Genetic Generalised Epilepsies (GGE)

A Systematic Review of Psychiatric and Psychosocial Comorbidities of Genetic Generalised Epilepsies (GGE)

The interictal dysphoric disorder in patients with epilepsy: A doubtful disorder lacking diagnostic tools

Mental health of children and adolescents with epilepsy: analysis of clinical and neuropsichological aspects

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