Specified iron oxide nanoparticles by PSMA-11 as a promising nanomolecular imaging probe for early detection of prostate cancer

Ghorbani, Farzaneh; Irajirad, Rasoul; Emami, Farshad; Nezamdoust, Fereshteh Vaziri; Montazerabadi, Alireza

doi:10.1007/s13204-022-02507-5

Cited by 2 publications

(8 citation statements)

References 34 publications

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“…Briefly, the BNPs exhibited less cyto-toxicity than the DNPs, whereas the DNPs revealed more magnetic properties. 28 Aside from this, it was found that TBNPs performed more effectively than TDNPs based on the in-vitro imaging and cell uptake examinations.…”

Section: Discussionmentioning

confidence: 80%

“…Besides, a faster clearance for DNPs would be done as a result of their smaller size. 28 Hence, the SI ratio of BNPs at T 2 -W sequences, which are less sensitive to magnetic susceptibility, was lower than that of DNPs at the 6 hours time point. The ID/g (%) data support this conclusion since the presence of DNPs in the kidneys was considerably higher than the presence of BNPs, indicating their more rapid excretion through the urinary system.…”

Section: Discussionmentioning

confidence: 89%

“…Previously, IONPs have been coated with BNP and Carboxymethylated‐dextran to obtain a surface for binding PSMA‐11‐HBED and PSMA‐11‐HYNIC peptides on IONPs. Briefly, the BNPs exhibited less cyto‐toxicity than the DNPs, whereas the DNPs revealed more magnetic properties 28 . Aside from this, it was found that TBNPs performed more effectively than TDNPs based on the in‐vitro imaging and cell uptake examinations.…”

Section: Discussionmentioning

confidence: 91%

“…This result is also consistent with the previous in-vitro study. 28 Depending on the image processing method, the difference in SI ratio reduction between groups may be significant or not. A higher SI ratio in the 3D method, which considers the entire tumor volume, may have to do with the nonuniform distribution of IONPs inside the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously tailored coated IONPs with Bovine Serum Albumin (BNPs, 68.25 mM −1 s −1 ) and Carboxyl‐methylated Dextran (DNPs, 159.84 mM −1 s −1 ) and targeted them with PSMA‐targeting Glu‐Urea‐Lys peptides including PSMA‐11‐HBED (TBNPs, 68.24 mM −1 s −1 ) and PSMA‐11‐HYNIC (TDNPs, 145.85 mM −1 s −1 ) 28 . The physio‐chemical properties of these nano‐structures as well as their contrast enhancement were investigated in‐vitro.…”

Section: Figurementioning

confidence: 99%

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Molecular MR Imaging of Prostate Cancer by Specified Iron Oxide Nanoparticles With PSMA‐11 Peptides: A Preclinical Study

Ghorbani

Aminzadeh

Borji

et al. 2023

Magnetic Resonance Imaging

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BackgroundProstate‐specific membrane antigen (PSMA) can provide a prostate cancer (PCa) detection approach in positron emission tomography (PET) using Food and Drug Administration (FDA)‐approved PSMA‐11 peptide. There are some studies evaluated magnetic‐nanoprobes for PSMA detection by MRI, using non‐FDA‐approved ligands including antibodies or peptides, which are not as specific as PSMA‐11.PurposeTo assess targeted iron oxide nanoparticles (IONPs) by PSMA‐11 peptides as a potential specific nano‐molecular probes to investigate a PSMA+ PCa‐xenograft model by MRI.Study TypeProspective.Animal ModelTwenty male C57BL6 nude mice induced subcutaneously PSMA+ LNCaP cell line tumor.Field Strength/Sequence1.5 T, T2‐W Fast Spin echo and T2*‐W Gradient echo.AssessmentCoated IONPs with Carboxymethylated‐dextran (DNPs) and with bovine serum albumin (BNPs), as well as, targeted DNPs with PSMA‐11‐HYNIC peptide (TDNPs) and targeted BNPs with PSMA‐11‐HBED peptide (TBNPs) were injected intravenously with dose 2.8 mg Fe/kg. Coronal T2‐W and the T2*‐W images were obtained before and 4 hours and 6 hours post‐injection. Signal intensity (SI) and relative signal enhancement (RSE) were computed in two‐ and three‐dimensional analyses. Histological analysis of tumors was evaluated, and the Fe distribution within the body based on atomic absorption spectroscopy was calculated.Statistical TestsOne‐way ANOVA followed by Tukey's multiple comparison test, Paired‐samples T‐test, P < 0.05 was considered significant.ResultsA reduction in T2‐W SI was achieved as 22 ± 7%, 59 ± 3%, 65 ± 5%, and 78 ± 3% respectively for BNPs, TBNPs, DNPs, and TDNPs 6 hours post‐injection. The most difference between targeted and non‐targeted groups was observed at 6 hours for PSMA‐11‐HBED, and at 4 hours for PSMA‐11‐HYNIC. RSE indicated 88.6 ± 3.1% and 80.7 ± 3.2% enhanced contrast between tumor and muscle region for TBNPs and TDNPs on T2*‐W images.ConclusionsBoth TBNPs and TDNPs are promising novel nano‐molecular probes for PSMA+ PCa tumor detection. The injection dose of non‐targeted IONPs can be reduced by using targeted nanoprobes three times for BNPs and two times for DNPs.Evidence Level1Technical EfficacyStage 1

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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