Specimen mammography distorts margin status in patients undergoing breast conserving surgery for early-stage breast cancer

Specimen mammography for intraoperative margin assessment in breast conserving surgery: a meta-analysis

“…Surgical specimen needs to be transported from the operating room to the radiology department, which makes it labor-intensive and time-consuming. The disadvantages of CSR also include low specificity, as additional excision of the tissue is often recommended unnecessarily 43 . Specimens examined with CSR are often compressed with a plate, to simulate the conditions of the mammographic examinations 22 .…”

“…Specimens examined with CSR are often compressed with a plate, to simulate the conditions of the mammographic examinations 22 . Kyle Ota believed that the high false positive rate may be caused by “pancake phenomenon 43 ”, where CSR compresses the surgical specimen. This manipulation refers to a reduction in the mean volume and height of the breast specimens which may increase FP margins 8 .…”

“…A wider negative margin distance defines those cases with close margins as pathologically positive. “Pancake phenomenon” causes the reduction in mean volume and height of the breast specimens, which also tends to define close margin cases as radiological positive 43 , leading to better diagnostic accuracy in the wider negative margin subgroup. Our study showed a significant difference in specificity between the two subgroups with higher specificity in the group with wider negative margins.…”

The application of intraoperative specimen mammography for margin status assessment in breast‐conserving surgery: A single‐center retrospective study

“…No significant difference was found between SR and frozen sectioning 5 . However, Kyle Ota reported a significant increase in false‐positive margins caused by SR 6 . The authors thought that it might be related to the “pancake phenomenon” in traditional SR, which compressed the specimen leading to a reduction in volume and height 7 .…”