Specimen self-collection for SARS-CoV-2 testing: Patient performance and preferences—Atlanta, Georgia, August-October 2020

O’Laughlin, Kevin; Espinosa, Catherine; Smith-Jeffcoat, Sarah E.; Koh, Mitsuki; Khalil, George; Hoffman, Adam; Rebolledo, Paulina A.; Schechter, Marcos C.; Stewart, Rebekah J; Silva, Juliana da; Biedron, Caitlin; Bankamp, Bettina; Folster, Jennifer; Gargis, Amy S.; Bowen, Michael D.; Paulick, Ashley; Wang, Yun F.; Tate, Jacqueline E.; Kirking, Hannah L.

doi:10.1371/journal.pone.0264085

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Self-sampling is an excellent approach in these situations, as it allows for more samples to be collected and screened in less time. Self-collection of upper respiratory tract samples via the nasal cavity (such as NS) or oral cavity (such as saliva, OS, or mouthwash) is, therefore, being investigated as a minimally invasive technique, which poses less risk of infection to HCWs, and does not require the use of expensive personal protective equipment [ 10 , 11 , 33 ]. Thus, self-collection could be easily conducted at home or in the community in cases where close contact is required with patients having SARS-CoV-2 infection for rapid screening and detection of the virus during mass infection, thereby, eliminating close interaction of HCWs individuals with SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

Performance Analysis of Self-Collected Nasal and Oral Swabs for Detection of SARS-CoV-2

Lim

Baek²,

Park³

et al. 2022

Diagnostics

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic human coronavirus and is rapidly transmitted by infected individuals regardless of their symptoms. During the COVID-19 pandemic, owing to the dearth of skilled healthcare workers (HCWs) to collect samples for early diagnosis, self-collection emerged as a viable alternative. To evaluate the reliability of self-collection, we compared the virus detection rate using 3990 self-collected swabs and HCW-collected swabs, procured from the same individuals and collected immediately after the self-collection. The results of multiplex reverse-transcription quantitative polymerase chain reaction revealed that the viral load in the HCW-collected swabs was marginally (18.4–28.8 times) higher than that in self-collected swabs. Self-collection showed no significant difference in sensitivity and specificity from HCW-collection (κ = 0.87, McNemar’s test; p = 0.19), indicating a comparable performance. These findings suggest that self-collected swabs are acceptable substitutes for HCW-collected swabs, and that their use improved the specimen screening efficiency and reduced the risk of SARS-CoV-2 infection among HCWs during and after the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

Performance Analysis of Self-Collected Nasal and Oral Swabs for Detection of SARS-CoV-2

Lim

Baek²,

Park³

et al. 2022

Diagnostics

View full text Add to dashboard Cite

show abstract

Performance of and preference for saliva sampling for detection of SARS-COV-2 in the Bahamas

Martin,

McMillan

2024

Preprint

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Implementing public health diagnostic modalities that are simultaneously accurate and acceptable is integral to effective pandemic response. In this regard, saliva has proven to be a reliable alternative to nasopharyngeal swabs (NPS) for the detection of SARS-COV-2 infections. In particular, the SalivaDirect protocol utilises untreated saliva as its sample type, and removes the need for RNA extraction, thereby decreasing the time and cost of diagnosis by RT-PCR. IN the current study we piloted SalivaDirect in the context of The Bahamas archipelago, where it demonstrated acceptable performance, with 95.2% concordance with NPS. However, there was discordance in 3 of the 8 total SARS-COV-2 positive samples, all of which were above Ct 30 and therefore presumably of low infectivity. Furthermore, a significant majority of survey respondents chose saliva as their preferred sample type and this was associated with citing "discomfort" of NPS sampling as the reason for their choice. These results support the practical use of SalivaDirect in the Bahamas as a mass testing tool.

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Specimen adequacy assay controls in nucleic acid amplification tests do not correlate with nasopharyngeal swab collection method

Crawford,

Baniecki,

Dushin

et al. 2024

J Clin Microbiol

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Specimen self-collection for SARS-CoV-2 testing: Patient performance and preferences—Atlanta, Georgia, August-October 2020

Cited by 3 publications

References 13 publications

Performance Analysis of Self-Collected Nasal and Oral Swabs for Detection of SARS-CoV-2

Performance Analysis of Self-Collected Nasal and Oral Swabs for Detection of SARS-CoV-2

Performance of and preference for saliva sampling for detection of SARS-COV-2 in the Bahamas

Specimen adequacy assay controls in nucleic acid amplification tests do not correlate with nasopharyngeal swab collection method

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