Speckle-based off-axis holographic detection for non-contact photoacoustic tomography

Buj, Christian; Horstmann, Jens; Münter, Michael; Brinkmann, Ralf

doi:10.1515/cdbme-2015-0088

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…For the realization of the non-contact PAT approach, a Mach-Zehnder based speckle interferometer (Buj et al 2014, Horstmann and is developed as photoacoustic detector as sketched in figure 1. The object surface is illuminated by a pulsed laser.…”

Section: Methodsmentioning

confidence: 99%

Full-field speckle interferometry for non-contact photoacoustic tomography

et al. 2015

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A full-field speckle interferometry method for non-contact and prospectively high speed Photoacoustic Tomography is introduced and evaluated as proof of concept. Thermoelastic pressure induced changes of the objects topography are acquired in a repetitive mode without any physical contact to the object. In order to obtain high acquisition speed, the object surface is illuminated by laser pulses and imaged onto a high speed camera chip. In a repetitive triple pulse mode, surface displacements can be acquired with nanometre sensitivity and an adjustable sampling rate of e.g. 20 MHz with a total acquisition time far below one second using kHz repetition rate lasers. Due to recurring interferometric referencing, the method is insensitive to thermal drift of the object due to previous pulses or other motion. The size of the investigated area and the spatial and temporal resolution of the detection are scalable. In this study, the approach is validated by measuring a silicone phantom and a porcine skin phantom with embedded silicone absorbers. The reconstruction of the absorbers is presented in 2D and 3D. The sensitivity of the measurement with respect to the photoacoustic detection is discussed. Potentially, Photoacoustic Imaging can be brought a step closer towards non-anaesthetized in vivo imaging and new medical applications not allowing acoustic contact, such as neurosurgical monitoring or burnt skin investigation.

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Section: Methodsmentioning

confidence: 99%

Full-field speckle interferometry for non-contact photoacoustic tomography

et al. 2015

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“…An attractive feature of all-optical sound detection in biomedical optoacoustic applications relates to the possibilities enabled by non-contact operation. DI and two-beam interferometry have been used for non-contact optoacoustic imaging 55 , 88 , 97 – 99 based on optical coherence technology 98 , 100 or holographic techniques 101 , 102 , opening up possibilities for dual-modality imaging. In these configurations, a probe beam is directed onto the sample surface, and vibrations of the tissue edge modulate the reflected light; in other words, the tissue–air interface serves as the reflector (Fig.…”

Section: Applicationsmentioning

confidence: 99%

Looking at sound: optoacoustics with all-optical ultrasound detection

et al. 2018

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Originally developed for diagnostic ultrasound imaging, piezoelectric transducers are the most widespread technology employed in optoacoustic (photoacoustic) signal detection. However, the detection requirements of optoacoustic sensing and imaging differ from those of conventional ultrasonography and lead to specifications not sufficiently addressed by piezoelectric detectors. Consequently, interest has shifted to utilizing entirely optical methods for measuring optoacoustic waves. All-optical sound detectors yield a higher signal-to-noise ratio per unit area than piezoelectric detectors and feature wide detection bandwidths that may be more appropriate for optoacoustic applications, enabling several biomedical or industrial applications. Additionally, optical sensing of sound is less sensitive to electromagnetic noise, making it appropriate for a greater spectrum of environments. In this review, we categorize different methods of optical ultrasound detection and discuss key technology trends geared towards the development of all-optical optoacoustic systems. We also review application areas that are enabled by all-optical sound detectors, including interventional imaging, non-contact measurements, magnetoacoustics, and non-destructive testing.

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“…In Ref. 11 , it could be demonstrated that recording speed and optical resolution can be increased when employing digital double exposure holography for the investigation of the deformations caused by acoustic waves. In Refs.…”

Section: Introductionmentioning

confidence: 99%

Large-field-of-view optical elastography using digital image correlation for biological soft tissue investigation

et al. 2017

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, "Large-field-of-view optical elastography using digital image correlation for biological soft tissue investigation," J. Med. Imag. 4(1), 014505 (2017), doi: 10.1117/1.JMI.4.1.014505. Abstract. In minimally invasive surgery the haptic feedback, which represents an important tool for the localization of abnormalities, is no longer available. Elastography is an imaging technique that results in quantitative elastic parameters. It can hence be used to replace the lost sense of touch, as to enable tissue localization and discrimination. Digital image correlation is the chosen elastographic imaging technique. The implementation discussed here is clinically sound, based on a spectrally engineered illumination source that enables imaging of biological surface markers (blood vessels) with high contrast. Mechanical loading and deformation of the sample is performed using a rolling indenter, which enables the investigation of large organs (size of kidney) with reduced measurement time compared to a scanning approach. Furthermore, the rolling indentation results in strain contrast improvement and an increase in detection accuracy. The successful application of digital image correlation is first demonstrated on a silicone phantom and later on biological samples. Elasticity parameters and their corresponding four-dimensional distribution are generated via solving the inverse problem (only two-dimensional displacement field and strain map experimentally available) using a well-matched hyperelastic finite element model. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Speckle-based off-axis holographic detection for non-contact photoacoustic tomography

Cited by 10 publications

References 6 publications

Full-field speckle interferometry for non-contact photoacoustic tomography

Full-field speckle interferometry for non-contact photoacoustic tomography

Looking at sound: optoacoustics with all-optical ultrasound detection

Large-field-of-view optical elastography using digital image correlation for biological soft tissue investigation

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