2011
DOI: 10.1371/currents.rrn1273
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Speckle tracking analysis of the left ventricular anterior wall shows significantly decreased relative radial strain patterns in dystrophin deficient mice after 9 months of age

Abstract: tracking analysis of the left ventricular anterior wall shows significantly decreased relative radial strain patterns in dystrophin deficient mice after 9 months of age. PLOS Currents Muscular Dystrophy. 2011 Oct 24 . Edition 1. doi: 10.1371/currents.RRN1273. AbstractBackground: Duchenne muscular dystrophy (DMD) is an inherited X-linked disorder with an incidence of 1 in 3,500 male births. Early treatment of DMD cardiomyopathy is under investigation and echocardiographic analysis of strain patterns may provide… Show more

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Cited by 8 publications
(11 citation statements)
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“…It detects cardiac dysfunction during the teenage years in DMD patients [24] and after the age of 6–9 months in mdx mice [2527]. The echocardiography technology has now advanced from global to local (e.g., motility, torsion, and strain) analysis [8, 23], which has been used in DMD patients [4, 20, 28, 29] and mdx mice [11] to diagnose cardiac dysfunction and is more sensitive than conventional echo in detecting cardiac function abnormalities. In our study, it seems that PSS is more sensitive for detecting the decrease in cardiac function than conventional M-mode.…”
Section: Discussionmentioning
confidence: 99%
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“…It detects cardiac dysfunction during the teenage years in DMD patients [24] and after the age of 6–9 months in mdx mice [2527]. The echocardiography technology has now advanced from global to local (e.g., motility, torsion, and strain) analysis [8, 23], which has been used in DMD patients [4, 20, 28, 29] and mdx mice [11] to diagnose cardiac dysfunction and is more sensitive than conventional echo in detecting cardiac function abnormalities. In our study, it seems that PSS is more sensitive for detecting the decrease in cardiac function than conventional M-mode.…”
Section: Discussionmentioning
confidence: 99%
“…High frequency ultrasound has become a valuable tool to phenotype cardiac structure, hemodynamics, and global function in small animals [810]. Furthermore, high frequency ultrasound based 2D speckle tracking echocardiography (STE) has been used to quantitatively measure myocardial strains and strain rates as potentially sensitive markers for early regional myocardial dysfunction in mdx mice, showing that peak systolic strain (PSS) analysis is feasible and reproducible for detecting LV dysfunction in mdx mice [11]. …”
Section: Introductionmentioning
confidence: 99%
“…3 Although several attempts have been made to implement these techniques in mice, published deformation data are not always convincing. [15][16][17][18] Among the most important concerns raised is the dependency on excellent image quality and the necessity of excluding animals where sufficient image quality is not achieved. 17,18 In contrast to our previous attempts at quantifying regional cardiac deformation by manually tracing tissue borders, intra-and inter-observer variability were acceptable with the present approach.…”
Section: Discussionmentioning
confidence: 99%
“…[15][16][17][18] Among the most important concerns raised is the dependency on excellent image quality and the necessity of excluding animals where sufficient image quality is not achieved. 17,18 In contrast to our previous attempts at quantifying regional cardiac deformation by manually tracing tissue borders, intra-and inter-observer variability were acceptable with the present approach. 7 Manual tracing is dependent on an experienced echocardiographer to trace the tissue border both in diastole and systole.…”
Section: Discussionmentioning
confidence: 99%
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