Speckle tracking echocardiography and left ventricular twist mechanics: predictive capabilities for noncompaction cardiomyopathy in the first degree relatives

Excessive Trabeculation of the Left Ventricle

“… 25 Specific functional indices proposed to diagnose or risk stratify patients with latent or overt cardiomyopathy with excessive trabeculation are attractive because they target the underlying functional disturbance. 26 , 27 , 28 , 29 They do not, however, provide evidence of causality to a possible morphologic appearance of excessive trabeculation.…”

Prevalence of left ventricular ‘rigid body rotation’, the near absence of left ventricular twist (insights from the MAGYAR studies)

“…Cw LV-RBR was detected in most NCCM cases [11,12,15,[18][19][20], which was found to be related to LV-EF [17]. Almost one-third of the relatives of NCCM patients showed LV-RBR, the ratio of Cw and CCw direction was the same [18]. Ratio of LV-RBR was significantly different between NCCM children and subjects with hypertrabecularization [19].…”

“…Specificity and sensitivity of LV-RBR was 88% and 78% in differentiating NCCM from LV "hypertrabeculation", respectively [12]. Cw LV-RBR was detected in most NCCM cases [11,12,15,[18][19][20], which was found to be related to LV-EF [17]. Almost one-third of the relatives of NCCM patients showed LV-RBR, the ratio of Cw and CCw direction was the same [18].…”

“…According to the literature, NCCM is the most extensively examined LV-RBR-related disease, where its prevalence ranged from 26% to 100% (Table 1) [11][12][13][14][15][16][17][18][19][20][21]. van Dalen et al [12] assessed patients with dilated cardiomyopathy (DCM), healthy subjects and cases with prominent trabeculations, of whom expert opinion in NCCM defined some of them having NCCM, and found that LV-RBR was an objective, quantitative and reproducible functional criterion, and had a good predictive value in the diagnosis of NCCM.…”

“…[17,[36][37][38][39][40][43][44][45][46][47][48][49]). Interestingly, while most cardiomyopathy patients showed Cw LV-RBR [11,12,15,18,19,22,23,25], patients with non-cardiac disorders without obvious cardiac involvement (lymphedema, acromegaly, following kidney transplantation) most likely had CCw LV-RBR [37,40,46].…”