SPECT in Dementia: Clinical and Pathological Correlation

Read, Stephen L.; Miller, Bruce L.; Mena, Ismaël; Kim, Ronald; Itabashi, Hideo H.; Darby, Amy

doi:10.1111/j.1532-5415.1995.tb07400.x

Cited by 100 publications

(52 citation statements)

References 33 publications

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“…SPECT and PET may be helpful in distinguishing FTD from AD. Many patients with FTD show hypoperfusion of anterior cerebral cortex with relative sparing of posterior cortex with SPECT [78][79][80] and PET. 81 In these four Class II studies, the highly selected study participant pool makes it difficult to generalize on the reported specificities and sensitivities.…”

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confidence: 99%

Practice parameter: Diagnosis of dementia (an evidence-based review)

et al. 2001

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Article abstract-Objective: To update the 1994 practice parameter for the diagnosis of dementia in the elderly. Background: The AAN previously published a practice parameter on dementia in 1994. New research and clinical developments warrant an update of some aspects of diagnosis. Methods: Studies published in English from 1985 through 1999 were identified that addressed four questions: 1) Are the current criteria for the diagnosis of dementia reliable? 2) Are the current diagnostic criteria able to establish a diagnosis for the prevalent dementias in the elderly? 3) Do laboratory tests improve the accuracy of the clinical diagnosis of dementing illness? 4) What comorbidities should be evaluated in elderly patients undergoing an initial assessment for dementia? Recommendations: Based on evidence in the literature, the following recommendations are made.

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confidence: 99%

Practice parameter: Diagnosis of dementia (an evidence-based review)

et al. 2001

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“…The changes in frontal and in temporal blood flow grow more marked as the disease progresses [43][44][45] providing information for diagnosing it in 90% of cases, especially if they are correlated with clinical parameters. 46 Therefore, there were also some difficulties posed by the neuroimaging and neuropsychological examinations described in the studies which also precluded the combined evaluation of data.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological treatment of frontotemporal lobar degeneration: systematic review

Portugal

Marinho

Laks

2011

Rev. Bras. Psiquiatr.

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Objective: To identify the therapeutic options available for treatment of cognitive and behavioral symptoms in frontotemporal lobar degeneration. Method: Systematic review using the descriptors "frontotemporal lobar degeneration" OR "frontotemporal dementia" OR "fronto-temporal dementia" OR "fronto-temporal degeneration" OR "Pick's disease" OR "Pick's atrophy" OR "semantic dementia" OR "progressive aphasia" AND "pharmacotherapy" OR "treatment" OR "efficacy" OR "effects" OR "management" was performed in the Medline and Lilacs databases. Selection criteria: Quality A -randomized clinical trials. Quality Bopen studies or reports of six or more cases. Quality C -reports of five or fewer cases. Two reviewers independently assessed the clinical studies. Information collected included diagnostic criteria used, sample size, duration, efficacy and tolerability measures used and results obtained. Results: From the 532 studies found, 29 complied with the inclusion criteria. All studies worked with a small sample, had short duration of treatment and used non-uniform measures in evaluating efficacy and tolerability. Studies showed disparate results with respect to behavior and cognition. Conclusion: There is still little, and poor, evidence available for treatment of frontotemporal lobar degeneration and studies with better methodological background are needed. Descriptors IntroductionThe clinical syndromes related to frontotemporal lobar degeneration (FTLD) are the second most common cause of pre-senile primary dementia. 1 A recent Brazilian epidemiological study found a dementia prevalence of 7.1% in individuals over

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“…Studies with no direct comparison found sensitivity of 93% and specificity of 74% using SPECT (Read et al, 1995), and 96% and 89% (Jobst et al, 1994). Initial regional cerebral blood flow SPECT studies of MCI may be useful in predicting patients who will develop AD in the near future (Hirao et al, 2005).…”

Section: Comparison With Mr Imaging Single Photon Emission Computed mentioning

confidence: 99%

[18F]Fluorodeoxyglucose Positron Emission Tomography in Alzheimer Disease and Related Disorders

Miyazawa¹,

Shinohara²

2012

Positron Emission Tomography - Current Clinical and Research Aspects

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SPECT in Dementia: Clinical and Pathological Correlation

Abstract: SPECT provides useful positive information in dementia, particularly the differentiation of AD, FTD, and JCD. However, it does not distinguish PD from AD.

Cited by 100 publications

References 33 publications

Practice parameter: Diagnosis of dementia (an evidence-based review)

Practice parameter: Diagnosis of dementia (an evidence-based review)

Pharmacological treatment of frontotemporal lobar degeneration: systematic review

[18F]Fluorodeoxyglucose Positron Emission Tomography in Alzheimer Disease and Related Disorders

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