Spectral analysis of fetal heart rate variability as a predictor of intrapartum fetal distress

Chung, D.Y.; Sim, Young Bo; Park, Kun Taek; Yi, Sang Hoon; Shin, Jung-Chul; Kim, S.P.

doi:10.1016/s0020-7292(01)00348-4

Cited by 53 publications

(60 citation statements)

References 15 publications

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“…Based on previous studies in this field, the frequency boundaries used in this study were as follows: VLF, 0-0.04 Hz; LF, 0.04-0.15 Hz; and HF, 0.15-0.4 Hz (Eckberg, 1997;Chung et al 2001;Min et al 2002;van Laar et al 2009). …”

Section: Spectral Analysismentioning

confidence: 99%

Ontogeny and control of the heart rate power spectrum in the last third of gestation in fetal sheep

Koome

Booth

Davidson

et al. 2013

Experimental Physiology

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New Findings r What is the central question of this study? Can power spectral analysis of fetal heart rate variability provide a reliable, objective estimate of autonomic balance before birth? r What is the main finding and its importance? This study demonstrates that there is a substantial increase in fetal heart rate spectral power over late gestation in chronically instrumented fetal sheep, with changes between sleep states that are consistent with known patterns of autonomic activity. However, parasympathetic blockade with atropine and complete chemical sympathectomy did not support substantial, consistent differences in the frequencies of sympathetic and parasympathetic activity in late gestation, suggesting that this does not provide a reliable index of relative cardiac autonomic activity before birth. Power spectral analysis of fetal heart rate variability has been proposed to provide a non-invasive estimate of autonomic balance. However, there are few systematic data before birth. We therefore examined developmental changes in the frequency power spectrum at very low (0-0.04 Hz), low (0.04-0.15 Hz) and high frequencies (0.15-0.4 Hz), as well as the ratio of low-to high-frequency power (LF/HF), in chronically catheterized, healthy fetal sheep at 0.6 (n = 8), 0.7 (n = 7) and 0.8 gestational age (ga; n = 11). In a second study, 0.8 ga fetuses received either atropine (4.8 mg bolus, then 4.8 mg h −1 for 30 min, n = 6) or 6-hydroxydopamine (20 mg ml −1 at 2.5 ml h −1 for 3 h; n = 9). Data were analysed by sleep state, defined by low-voltage-high-frequency (LV) or high-voltage-low-frequency (HV) EEG. Total spectral power increased with gestational age (P < 0.05), while LF/HF decreased from 0.6 to 0.7 ga. At 0.8 ga, heart rate and LF/HF were significantly higher during HV than LV sleep (P < 0.05). Consistent with this, although total spectral power was not significantly greater during HV sleep, there was a significant interaction between sleep state and frequency band (P = 0.02). Both atropine (P = 0.05) and 6-hydroxydopamine (P < 0.05) were associated with an overall reduction in spectral power but no significant effect on the LF/HF ratio. This study does not support substantial, consistent differences between the frequencies of sympathetic and parasympathetic activity in late-gestation fetal sheep.

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Section: Spectral Analysismentioning

confidence: 99%

Ontogeny and control of the heart rate power spectrum in the last third of gestation in fetal sheep

Koome

Booth

Davidson

et al. 2013

Experimental Physiology

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“…[8][9][10][11][12][13][14][15] Few 1 studies, based on these statistical tools, focused on FHR variability analysis during labor to detect hypoxia or acidosis, with variable results. [16][17][18][19][20][21] Multifractal analysis is a recent technique that aims at providing detailed and elaborated analysis of data variability, particularly adapted for characterization of nonstationary and complex signals like FHR. 22,23 Although variability is clinically analyzed by considering the largest difference in data (referred to as ''oscillation'') observed within a sliding time window of a priori chosen size (usually 1 minute), multifractal analysis focuses on characterizing the evolution of the variability measured in a collection of windows of different growing sizes, within a relevant range that is a posteriori and adaptively determined by the method itself.…”

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confidence: 99%

Multifractal Analysis of Fetal Heart Rate Variability in Fetuses with and without Severe Acidosis during Labor

et al. 2010

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We performed multifractal analysis of fetal heart rate (FHR) variability in fetuses with and without acidosis during labor. Multifractal analysis was performed on fetal electrocardiograms in 10-minute sliding windows within the last 2 hours before delivery in 45 term fetuses divided in three groups according to umbilical arterial pH and FHR pattern: group A had pH !7.30 and normal FHR, group B had pH !7.30 and intermediate or abnormal FHR, and group C had acidosis (pH 7.05) and intermediate or abnormal FHR. Six multifractal parameters were compared using Wilcoxon rank sum test. Multifractal parameters were significantly different between the three groups in the last 10 minutes before delivery (p <0.05). Two parameters (h min , zeta(2)) exhibited a significant difference 70 minutes before delivery, and one parameter (C 2 ) was different 10 minutes before birth (p <0.05). Multifractal parameters were significantly different in acidotic and nonacidotic fetuses, independently from FHR pattern.

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“…The complex wave structure of the fetal cardiorythmogram stipulates for the use of the time and frequency domain methods when analyzing vague CTGs. The majority of papers focused on the study of fetal state distortion by using the methods of time and frequency analysis have respect to the diagnostics of fetal distress during childbirth [7,8,12,[18][19][20][21]. We, however, believe that it is of utmost importance to monitor the fetus in the late weeks of gestation.…”

Section: Resultsmentioning

confidence: 99%

“…Stable ECG signal generation alongside with fetal electrocardiogram morphology analysis has become the focus of numerous research investigations [6]. These are complemented with papers on the spectral analysis of transabdominal fetal electrocardiograms used for diagnosing fetal hypoxia during childbirth [7,8]. Fetal electrocardiography is currently considered as an alternative to Doppler ultrasonic cardiotocography so far as the antenatal assessment of fetal condition is.…”

Section: Introductionmentioning

confidence: 99%

Differential Diagnosis of Monotonous Fetal Heart Rate

Karpov¹,

Симакова²,

Frolova³

et al. 2017

Obstetrics

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The aim was to explore the possibility to forecast a risk of hypoxic lesions in a monotonous fetal heart rate via ECG measurements by the methods of time and frequency analysis. The study involved 50 healthy pregnant women with singleton pregnancy at 37-41 weeks of gestation along with 17 pregnant women in the same period of gestation who had a monotonous fetal heart rate registered of various origin. The registration of fetal heart rates was performed using fetal monitor "Monica AN24" ("Monica Healthcare Ltd", United Kingdom), transabdominal, using ECG electrodes. The software package "Monica DK" has been used to retrieve the "beat-to-beat" data. Analysis of experimental data was carried out on the basis of LABVIEW ® software (National Instruments ® , USA). The analysis of time parameters for fetal hypoxia showed a sharp decline in the spread function and a sharp increase in the concentration function. Spectral analysis showed a significant decrease in the ratio of high-to low-frequency components of the spectrum. In the analysis of fetal ECG, the ST segment depression was noted, which is also indicative of fetal hypoxia.

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Spectral analysis of fetal heart rate variability as a predictor of intrapartum fetal distress

Abstract: A computerized spectral analysis of fetal heart rate variation is a good predictor of fetal distress, which is made automatically and objectively.

Cited by 53 publications

References 15 publications

Ontogeny and control of the heart rate power spectrum in the last third of gestation in fetal sheep

Ontogeny and control of the heart rate power spectrum in the last third of gestation in fetal sheep

Multifractal Analysis of Fetal Heart Rate Variability in Fetuses with and without Severe Acidosis during Labor

Differential Diagnosis of Monotonous Fetal Heart Rate

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