Spectral Analysis of Intraocular Pressure Pulse Wave in Open Angle Glaucomas and Healthy Eyes

Božić, Marija; Dukic, M.L.; Stojković, Marija Mostarica

doi:10.3109/02713683.2012.700755

Cited by 10 publications

(16 citation statements)

References 16 publications

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“…Spectral analysis of the ocular pulse amplitude reported by dynamic contour tonometry had shown statistical differences between subjects with different types of glaucoma [19], [26]. Statistically significant differences were found between the harmonics of patients with primary open angle glaucoma and normal tension glaucoma, which may lead to newer diagnostic measures for identifying glaucoma suspects [19]. Age was not significantly correlated with any of the variables in this study and in past studies with other variables [27], [28].…”

Section: Discussioncontrasting

confidence: 55%

“…These studies have highlighted salient features of the ORA waveform that could be useful for diagnosis of disease, e.g., a wider area under 1st or 2nd peak indicated a weaker cornea as the weaker cornea deformed slowly [17], [18]. Spectral analysis of the ocular pulse amplitude reported by dynamic contour tonometry had shown statistical differences between subjects with different types of glaucoma [19], [26]. Statistically significant differences were found between the harmonics of patients with primary open angle glaucoma and normal tension glaucoma, which may lead to newer diagnostic measures for identifying glaucoma suspects [19].…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, some amount of spectral leakage can occur from Fourier transform. In spectral analysis of ocular pressure pulse wave, several continuous waveforms are available but not in ORA and CoST [19], [21], [22], [27], [28]. This limitation may be overcome to some extent in CoST, if the complete deformation history, i.e., corneal DA reached to zero, was provided.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, CoST reports the corneal displacement (magnitude and direction of motion). Recent studies have shown that spectral analysis of ocular waveforms can provide useful information pertaining to clinical diagnosis of conditions [18], [19]. In this study, spectral analyses of the waveforms reported by ORA and CoST in a cohort of patients with apparent normal corneas were conducted.…”

Section: Introductionmentioning

confidence: 99%

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Biomechanics of the Cornea Evaluated by Spectral Analysis of Waveforms from Ocular Response Analyzer and Corvis-ST

et al. 2014

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PurposeIn this study, spectral analysis of the deformation signal from Corvis-ST (CoST) and reflected light intensity from ocular response analyzer (ORA) was performed to evaluate biomechanical concordance with each other.MethodsThe study was non-interventional, observational, cross-sectional and involved 188 eyes from 94 normal subjects. Three measurements were made on each eye with ORA and CoST each and then averaged for each device. The deformation signal from CoST and reflected light intensity (applanation) signal from ORA was compiled for all the eyes. The ORA signal was inverted about a line joining the two applanation peaks. All the signals were analyzed with Fourier series. The area under the signal curves (AUC), root mean square (RMS) of all the harmonics, lower order (LO included 1st and 2nd order harmonic), higher order (HO up to 6th harmonic), CoST deformation amplitude (DA), corneal hysteresis (CH) and corneal resistance factor (CRF) were analyzed.ResultsThe device variables and those calculated by Fourier transform were statistically significantly different between CoST and ORA. These variables also differed between the eyes of the same subject. There was also statistically significant influence of eyes (left vs. right) on the differences in a sub-set of RMS variables only. CH and CRF differed statistically significantly between the eyes of subject (p<0.001) but not DA (p = 0.65).ConclusionsCoST was statistically significantly different from ORA. CoST may be useful in delineating true biomechanical differences between the eyes of a subject as it reports deformation.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomechanics of the Cornea Evaluated by Spectral Analysis of Waveforms from Ocular Response Analyzer and Corvis-ST

et al. 2014

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“…In a small study of 10 normal subjects and 10 untreated glaucoma patients, they showed that the 2nd, 3rd and 4th harmonic components of the IOP pulse wave were significantly different between the groups. Recently, Božić and colleagues [17] have performed a similar study including a control group of 20 subjects and two groups of glaucoma patients including 20 with primary open angle glaucoma and 20 with normal tension glaucoma. There again, the spectral content of the intraocular pressure pulse wave, measured with DCT, showed differences between the groups.…”

Section: Introductionmentioning

confidence: 99%

Clinical utility of spectral analysis of intraocular pressure pulse wave

Asejczyk-Widlicka

Krzyżanowska-Berkowska

Kowalska

et al. 2014

BMC Ophthalmol

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BackgroundTo evaluate the clinical utility of spectral analysis of intraocular pressure pulse wave in healthy eyes of a control group (CG), patients having glaucomatous optic disc appearance or ocular hypertension, and patients with primary open angle glaucoma or primary angle closure glaucoma.MethodsThis is a prospective study that enrolled 296 patients from a single glaucoma clinic. Age matched CG consisted of 62 individuals. Subjects underwent comprehensive clinical diagnostic procedures including intraocular pressure (IOP) measurement with dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT). DCT time series were analyzed with custom written software that included signal preprocessing, filtering and spectral analysis. An amplitude and energy content analysis, which takes into account non-stationarity of signals but also provides methodology that is independent of IOP and ocular pulse amplitude (OPA) levels, was applied. Spectral content up to the 6th harmonic of the pressure pulse wave was considered. Statistical analyses included descriptive statistics, normality test, and a multicomparison of medians for independent groups using Kruskal-Wallis test.ResultsGAT IOP showed statistical significance (Kruskal-Willis test p < 0.05) for three out of 10 considered multiple comparisons, DCT IOP and OPA showed statistically significant results in five and seven cases, respectively. Changes in heart rate and central corneal thickness between the groups were statistically significant in two cases. None of the above parameters showed statistically significant differences between CG and the suspects with glaucomatous optic disc appearance (GODA). On the other hand, spectral analysis showed statistically significant differences for that case.ConclusionsSpectral analysis of the DCT signals was the only method showing statistically significant differences between healthy eyes and those of GODA suspects.

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Changes in spectral parameters of corneal pulse following canaloplasty

Danielewska

Kicińska

Plaček

et al. 2019

Graefes Arch Clin Exp Ophthalmol

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Purpose To ascertain whether changes in the spectral content of the corneal pulse (CP) signal, measured in vivo in primary openangle glaucoma (POAG) patients, indirectly reflect changes in corneal biomechanics after canaloplasty. Methods Fifteen eyes of 15 POAG patients who underwent canaloplasty combined with phacoemulsification were enrolled. Standard ophthalmic examinations were conducted before washout, pre-operatively, at days 1, 7, and 1, 3, 6, and 12 months after surgery. Non-contact measurements of the CP signal were performed at pre-washout, pre-operatively, and at 3, 6, and 12 months post-operatively. Then, amplitudes of the CP first five harmonics associated with the heart rate were estimated. Temporal changes of all considered parameters were tested at a Bonferroni-adjusted significance level set to 0.005. Results A decrease in the amplitude of the first harmonic and an increase in the normalized amplitude of the third harmonic (A CP3n) of the CP signal were noticed between the pre-washout and the pre-operative stages (p = 0.003 and p = 0.004, respectively). This corresponds to an increase in median intraocular pressure (IOP) values by 6.0 mmHg (p = 0.0045). After surgery, A CP3n reached the highest value at 3 months post-operatively, compared with pre-washout level (p = 0.0045). Conclusions Alterations in corneoscleral stiffness caused by surgery are reflected in changes in the A CP3n value. Hence, postoperative corneal biomechanics could be monitored indirectly by this supporting indicator that can be used to estimate the time at which measures of IOP are no longer biased by the changed cornea boundary conditions caused by canaloplasty. Clinical Trials Registration NCT02908633

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Spectral Analysis of Intraocular Pressure Pulse Wave in Open Angle Glaucomas and Healthy Eyes

Cited by 10 publications

References 16 publications

Biomechanics of the Cornea Evaluated by Spectral Analysis of Waveforms from Ocular Response Analyzer and Corvis-ST

Biomechanics of the Cornea Evaluated by Spectral Analysis of Waveforms from Ocular Response Analyzer and Corvis-ST

Clinical utility of spectral analysis of intraocular pressure pulse wave

Changes in spectral parameters of corneal pulse following canaloplasty

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