Spectral and Mechanistic Investigation of Oxidation of Rizatriptan by Silver Third Periodate Complex in Aqueous Alkaline Medium

Khan, Aftab Aslam Parwaz; Khan, Anish; Kashmery, Heba A.

doi:10.1134/s199079311803003x

Cited by 3 publications

References 28 publications

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Synthesis of Silver Nanoparticles Through Orange Peel Powder for Antibacterial Composite Filler Applications

Rathinavel¹,

Saravanakumar²

2021

J Polym Environ

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Environmental concerns and the positive aspects of biowaste materials gained the attention of researchers to use them as filler materials in fabricating of green composites along with polymer matrices, but most of them are not suitable for extensive applications in high thermal applications. In most of the natural particulate materials are not having the ability to fight against pathogens. To overcome such barriers, a modification of biowaste -Orange Peel Powder (OPP) by the generation of silver nanoparticles (AgNPs) is prepared with the one-step hydrothermal process. The modified Orange Peel Powder (MOPP), is then characterized by FESEM, EDX, FT-IR, XRD, and Thermal analyses. The presence of AgNPs in the MOPP is confirmed through FESEM & EDX analysis. FT-IR spectral analysis pronounced the non mutate functional groups in MOPP as compared with OPP. The generation of AgNPs in MOPP is confirmed through the XRD peaks of reflection planes atThermal Analysis results of TGA and DSC show the MOPP has increased thermal stability up to 363°C.Antibacterial test against Gram-negative and Gram-positive bacteria for OPP & MOPP shows the inclusion of Ag strongly objects the pathogens. Eventually, the MOPP can be utilized as filler material along with the polymer matrix in high thermal as well as antibacterial composite filler applications.

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Synthesis of Silver Nanoparticles Through Orange Peel Powder for Antibacterial Composite Filler Applications

Rathinavel¹,

Saravanakumar²

2021

J Polym Environ

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Chloramine-T-induced oxidation of Rizatriptan Benzoate: An integral chemical and spectroscopic study of products, mechanisms and kinetics

Malini,

Raj,

Kumari

et al. 2023

Open Chemistry

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Oxidation is a prominent degradation route of biological molecules that produces a wide variety of degradation products through complex mechanisms and hence qualifies to be a vital pharmaceutical process. This article presents the kinetic and spectral study of the oxidation of an antimigraine drug rizatriptan benzoate (RTB) in an acid medium with the aid of a mild biocidal oxidant N-chloro-p-toluenesulfonamide, referred to as chloramine-T (CAT). The kinetic experimental studies reported here, such as fractional order dependency on RTB, pseudo-first-order dependency on CAT, negative fractional order dependency on the acid medium, independent of the rate on the ionic concentration and increasing rate with increasing dielectric constant, have led to the evaluation of stoichiometry, thermodynamic properties, and derivation of a rate equation. Effective interpretation of UV–Vis, IR, 1H and 13C NMR investigation was performed to identify and confirm the identity of the oxidation products and discuss the involved plausible mechanism. This study provides an extended insight into the products of oxidation formed during the metabolism of RTB.

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Synthesis of Silver Nanoparticles through Orange Peel Powder for Antibacterial Composite Filler Applications

Rathinavel¹,

Saravanakumar²

2021

Preprint

View full text Add to dashboard Cite

Environmental concerns and the positive aspects of biowaste materials gained the attention of researchers to use them as filler materials in fabricating of green composites along with polymer matrices, but most of them are not suitable for extensive applications in high thermal applications. In most of the natural particulate materials are not having the ability to fight against pathogens. To overcome such barriers, a modification of biowaste - Orange Peel Powder (OPP) by the generation of silver nanoparticles (AgNPs) is prepared with the one-step hydrothermal process. The modified Orange Peel Powder (MOPP), is then characterized by FESEM, EDX, FT-IR, XRD, and Thermal analyses. The presence of AgNPs in the MOPP is confirmed through FESEM & EDX analysis. FT-IR spectral analysis pronounced the non mutate functional groups in MOPP as compared with OPP. The generation of AgNPs in MOPP is confirmed through the XRD peaks of reflection planes at (1,1,1), (2,0,0), (2,2,0) & (3,1,1). Thermal Analysis results of TGA and DSC show the MOPP has increased thermal stability up to 363°C. Antibacterial test against Gram-negative and Gram-positive bacteria for OPP & MOPP shows the inclusion of Ag strongly objects the pathogens. Eventually, the MOPP can be utilized as filler material along with the polymer matrix in high thermal as well as antibacterial composite filler applications.

show abstract

Spectral and Mechanistic Investigation of Oxidation of Rizatriptan by Silver Third Periodate Complex in Aqueous Alkaline Medium

Cited by 3 publications

References 28 publications

Synthesis of Silver Nanoparticles Through Orange Peel Powder for Antibacterial Composite Filler Applications

Synthesis of Silver Nanoparticles Through Orange Peel Powder for Antibacterial Composite Filler Applications

Chloramine-T-induced oxidation of Rizatriptan Benzoate: An integral chemical and spectroscopic study of products, mechanisms and kinetics

Synthesis of Silver Nanoparticles through Orange Peel Powder for Antibacterial Composite Filler Applications

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