Spectral and sequence similarity between vasoactive intestinal peptide and the second conserved region of human immunodeficiency virus type 1 envelope glycoprotein (gp120): Possible consequences on prevention and therapy of aids

Veljković, Veljko; Metlaš, R.; Raspopovic, Jadranka; Pongor, Sándor

doi:10.1016/0006-291x(92)92258-y

Cited by 28 publications

(19 citation statements)

References 17 publications

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“…We can, however, assume that: these antibodies are (1) elicited by low levels of HIV-specific stimulation (possibly by a conformational epitope) or they are (2) elicited by some HIVunrelated antigenic stimulation. Support for the latter hypothesis comes from previous studies indicating that anti-NTM antibodies are autoantibodies to VIP [34] found in some human individuals [20].…”

Section: Discussionmentioning

confidence: 76%

The Presence of Antibodies Recognizing a Peptide Derived from the Second Conserved Region of HIV-1 gp120 Correlates with Non-Progressive HIV Infection

Djordjević¹,

Veljković²,

Antoni³

et al. 2007

CHR

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The C-terminus of the second conserved region of HIV-1 gp120 represents a functionally important domain, as it encompasses amino acids directly involved in the binding to the CD4 receptor and in post-receptor binding events. Previous studies have suggested that antibodies with specific affinity to a 23 amino acids-long NTM polypeptide, derived from this HIV-1 gp120 domain, may be involved in the control of HIV disease progression. In the current work, we searched for NTM-recognizing antibodies in specific cohorts of HIV-1 infected individuals, including long-term nonprogressors (LTNP) and progressors. For this purpose, we employed a previously defined bioinformatics criterion for design of an NTM peptide mimetic to select an octapeptide, NTMs (FTDNAKTI), which is more suitable for use in a solid-state enzyme-linked immunosorbent assay (ELISA). Our results show that NTMs-reactive antibodies are significantly more prevalent (p < 0.01) in LTNP as compared to progressors and healthy control subjects, indicating their association with non-progressive infection. The presence of antibodies recognizing the second conserved region of the HIV-1 gp120 derived peptide, NTMs, in LTNP sera suggest that these antibodies could be of considerable interest for development of anti-HIV immune-based therapies and vaccines.

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Section: Discussionmentioning

confidence: 76%

The Presence of Antibodies Recognizing a Peptide Derived from the Second Conserved Region of HIV-1 gp120 Correlates with Non-Progressive HIV Infection

Djordjević¹,

Veljković²,

Antoni³

et al. 2007

CHR

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“…It has been proposed that these antibodies represent natural anti-vasoactive intestinal peptide (VIP) antibodies, because the domain of the HIV-1 gp120 encompassing peptide C2 is not immunogenic in humans (Veljković et al, 1992(Veljković et al, , 1993. Recently we demonstrated that peptide RSANFTDNAKTI-IVQLNESVEIN derived from peptide C2 and VIP showed similar reactivity profiles when tested against a battery of sera from 46 AIDS patients (Veljkovic et al, 2003).…”

Section: Resultsmentioning

confidence: 92%

“…It has been demonstrated that antibodies with specific affinity (or cross reactivity) to the HIV-1 envelope protein (gp120 surface antigen, residues 280-302, RSANFTDNAK-TIIVQLNQSVEIN, designated peptide NTM), which represent, in fact, naturally occurring autoantibodies (designated as anti-VIP/NTM antibodies) with a specificity to vasoactive intestinal peptide (VIP) (Veljković et al, 1992(Veljković et al, , 1993, may be directly involved in control of HIV disease progression (Neurath et al, 1990;Veljković et al, 2001b;Branch et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease

Veljković

Branch

Metlas³

et al. 2004

Journal of Clinical Virology

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“…This analysis has been used successfully to predict the function, structure, and evolutionary history of biological sequences. Multiple sequence alignment is also used in AIDS and cancer studies, where it has, for example, been used to develop AIDS vaccine components [48].…”

Section: Introductionmentioning

confidence: 99%

Parallel computation in biological sequence analysis

Yap

Martino

1998

IEEE Trans. Parallel Distrib. Syst.

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A massive volume of biological sequence data is available in over 36 different databases worldwide, including the sequence data generated by the Human Genome project. These databases, which also contain biological and bibliographical information, are growing at an exponential rate. Consequently, the computational demands needed to explore and analyze the data contained in these databases is quickly becoming a great concern. To meet these demands, we must use high performance computing systems, such as parallel computers and distributed networks of workstations. We present two parallel computational methods for analyzing these biological sequences. The first method is used to retrieve sequences that are homologous to a query sequence. The biological information associated with the homologous sequences found in the database may provide important clues to the structure and function of the query sequence. The second method, which helps in the prediction of the function, structure, and evolutionary history of biological sequences, is used to align a number of homologous sequences with each other. These two parallel computational methods were implemented and evaluated on an Intel iPSC/860 parallel computer. The resulting performance demonstrates that parallel computational methods can significantly reduce the computational time needed to analyze the sequences contained in large databases.

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Spectral and sequence similarity between vasoactive intestinal peptide and the second conserved region of human immunodeficiency virus type 1 envelope glycoprotein (gp120): Possible consequences on prevention and therapy of aids

Cited by 28 publications

References 17 publications

The Presence of Antibodies Recognizing a Peptide Derived from the Second Conserved Region of HIV-1 gp120 Correlates with Non-Progressive HIV Infection

The Presence of Antibodies Recognizing a Peptide Derived from the Second Conserved Region of HIV-1 gp120 Correlates with Non-Progressive HIV Infection

Antibodies reactive with C-terminus of the second conserved region of HIV-1gp120 as possible prognostic marker and therapeutic agent for HIV disease

Parallel computation in biological sequence analysis

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