Spectral characterization and DNA binding properties of lanthanide(III) complexes with 2-acetylpyridine isonicotinoylhydrazone (APINH)

Abstract

ABSTRACT. The lanthanide(III) complexes of general formula of [Ln(APINH)2(NO3](NO3)2.nH2O (where, Ln = La, Ce, Pr, Nd, Sm; APINH = 2-acetylpyridine isonicotinoyl hydrazone, n = 0, 2 and 5 for La/Ce/Pr, Sm and Nd complexes, respectively) were synthesized under mild reaction conditions with excellent yields. The complexes were characterized based on elemental analysis, molar conductivity, and infrared spectroscopy. Molar conductivity data suggest that the complexes are 1:2 electrolytes. IR spectral data suggest that APINH acts as neutral tridentate ligand. Spectral data of complexes suggest that the ligand binds metal ion through pyridinenitrogen, azomethine-nitrogen and amido-oxygen donor atoms. Electrochemical behaviour of metal complexes was investigated by using cyclic voltammetry. The complexes undergo quasi-reversible one electron reduction. The binding interaction of complexes with CT-DNA was investigated using absorption spectrophotometry. Based on spectral changes, groove binding of complexes to DNA is suggested.

Raman spectra of copper, cobalt, and nickel complexes of nicotinic acid: Equilibrium studies

“…Some of these complexes are known to escalate the biological properties of the original ligand thus triggered many researchers to develop new novel complexes between a biologically active ligand and metal ion (usually the transition metal groups) to improve the ligand biological properties. Several analyses which are frequently used to determine the structure of the complex are elemental analysis, Fourier transform infrared (FTIR) spectroscopy, UV-Vis spectroscopy, nuclear magnetic resonance (NMR), and Raman spectroscopy [30][31][32]. Additionally, the conductivity and magnetic susceptibility behavior of the compounds were often observed.…”

Untitled

“…Interaction of metal complexes with nucleic acids is an exciting area of research due to their potential use as drugs, tools for biochemical and biomedical applications in gene regulation. Considerable efforts are being made in our laboratories to investigate metal-DNA interactions [4][5][6] and to develop drugs. Thus, looking to the importance of DNA binding agents with essential metal complexes for successful development of antimicrobial agents, herein we report the synthesis, characterization, DNA binding properties and anti bacterial activity of Cu(II), Ni(II), Co(II) and Zn(II) complexes of cuminaldehyde benzoylhydrazone (CABH).…”

“…IR data suggest that the ligand acts as mono anionic bidentate ligands in all metal complexes. The non-ligand bands in 692-699 and 508-533 cm -1 regions are tentatively assigned to ν (M-O), and ν (M-N) vibrations9 , respectively.…”

Synthesis, characterization and crystal structures of hydrazone compounds derived from isonicotinohydrazide

“…It can react with aldehydes to form isonicotinohydrazones, which show interesting biological activities [1][2][3][4]. Moreover, isonicotinohydrazone compounds usually possess three or more donor atoms, which can readily form complexes with various metal atoms [5][6][7][8][9][10][11][12]. Recently, we found that halido-substituted hydrazones have potential antimicrobial activities [13].…”