Spectral Characterization, Dna Binding Properties and Antibacterial Activity of New Metallo-Hydrazones

Abstract

Metallo-hydrazones having the formula [M(DABH)2] (Where, M = Co(II), Ni(II), Cu(II) and Zn(II); DABH = 4-dimethylaminobenzaldehyde benzoylhydrazone) are prepared and characterized based on physicochemical and spectral analyses. Molar conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (Kb) data revealed that the cobalt complex interacted DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal-free hydrazone ligand. The cobalt compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article.