Spectral characterization, electrochemical and anticancer studies on some metal(II) complexes containing tridentate quinoxaline Schiff base

Chellaian, Justin Dhanaraj; Johnson, Jijo

doi:10.1016/j.saa.2014.02.075

Cited by 46 publications

(21 citation statements)

References 29 publications

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“…Due to the coordination of azomethine nitrogen to the metal ions, this band is seen in the absorption spectra of all complexes at 317–335 nm. Also, the band due to π–π* transition is observed at 213–245 nm in the spectra of all metal complexes …”

Section: Resultsmentioning

confidence: 87%

Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Mahmoud

Deghadi

Mohamed

2016

Applied Organom Chemis

128

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A novel Schiff base ligand (H2L) was prepared through condensation of 2,6‐diaminopyridine and o‐benzoylbenzoic acid in a 1:2 ratio. This Schiff base ligand was characterized using elemental and spectroscopic analyses. A new series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal complexes of H2L were prepared and characterized using elemental analysis, spectroscopy (1H NMR, mass, UV–visible, Fourier transform infrared, electron spin resonance), magnetic susceptibility, molar conductivity, X‐ray powder diffraction and thermal analysis. The complexes are found to have trigonal bipyramidal geometry except Cr(III), Mn(II) and Fe(III) complexes which have octahedral geometry based on magnetic moment and solid reflectance measurements. The infrared spectral studies reveal that H2L behaves as a neutral bidentate ligand and coordinates to the metal ions via the two azomethine nitrogens. 1H NMR spectra confirm the non‐involvement of the carboxylic COOH proton in complex formation. The presence of water molecules in all reported complexes is supported by thermogravimetric studies. Kinetic and thermodynamic parameters were determined using Coats–Redfern and Horowitz–Metzger equations. The synthesized ligand and its complexes were screened for antimicrobial activities against two Gram‐positive bacteria (Bacillus subtilis and Staphylococcus aureus), two Gram‐negative bacteria (Escherichia coli and Neisseria gonorrhoeae) and one fungus (Candida albicans). Anticancer activities of the ligand and its metal complexes against human breast cancer cell line (MCF7) were investigated. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 87%

Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Mahmoud

Deghadi

Mohamed

2016

Applied Organom Chemis

128

View full text Add to dashboard Cite

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“…The anticancer activity of the complex was investigated on human breast (MCF-7) and cervical (HeLa) cancer cell lines using MTT assay as described previously [51,52]. The cytotoxicity of the complex was also studied on the normal human fibroblast cells.…”

Section: In Vitro Anticancer Activity Evaluationmentioning

confidence: 99%

Self-recognition of the racemic ligand in the formation of homochiral dinuclear V(V) complex: In vitro anticancer activity, DNA and HSA interaction

Kazemi

Rudbari

Mirkhani

et al. 2017

European Journal of Medicinal Chemistry

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“…The significant differences in the compounds' cytotoxicity were supported by the results of the selectivity index (S.I. ), which is the ratio of the concentration that causes 50% death in African green monkey kidney (VERO) (CC 50 ) compared to the concentration that causes 50% death in colon carcinoma cell line (HCT-116) (IC 50 ) [56][57][58].…”

Section: In Vitro Anticancer Studiesmentioning

confidence: 99%

Synthesis, spectroscopic properties, molecular docking, anti-colon cancer and anti-microbial studies of some novel metal complexes for 2-amino-4-phenylthiazole derivative

Al‐Harbi

Bashandy

Al-Saidi

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Spectral characterization, electrochemical and anticancer studies on some metal(II) complexes containing tridentate quinoxaline Schiff base

Cited by 46 publications

References 29 publications

Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Novel Schiff base ligand and its metal complexes with some transition elements. Synthesis, spectroscopic, thermal analysis, antimicrobial and in vitro anticancer activity

Self-recognition of the racemic ligand in the formation of homochiral dinuclear V(V) complex: In vitro anticancer activity, DNA and HSA interaction

Synthesis, spectroscopic properties, molecular docking, anti-colon cancer and anti-microbial studies of some novel metal complexes for 2-amino-4-phenylthiazole derivative

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