We propose a reliable scheme to simulate tunable and ultrastrong mixed-optomechanical interactions in a coupled two-mode bosonic system, in which the two modes are coupled with each other via a cross-Kerr interaction and one of the two modes is driven through both the single-and two-excitation processes. We show that the mixed optomechanical interaction can enter the single-photon strong-coupling even ultrastrong-coupling regimes. The strengthes of both the first-order and quadratic optomechanical couplings can be controlled on demand, and hence first-order, quadratic, and mixed optomechanical models can be obtained. In particular, the thermal noise of the driven mode can be suppressed totally by introducing a proper squeezed vacuum bath. We also study how to generate the superposition of the coherent squeezed state and vacuum state based on the simulated interactions. The quantum coherence effect in the generated states is characterized by calculating the Wigner function in both the closed-and open-system cases. This work will pave the way to the observation and application of ultrastrong optomechanical effects in quantum simulators.