Spectral cues are necessary to encode azimuthal auditory space in the mouse superior colliculus

Ito, Setsuro; Si, Yufei; Feldheim, David A.; Litke, A. M.

doi:10.1101/704031

Cited by 5 publications

(31 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1c, d. Consistent with what is known about the location of visual and auditory neurons in the mouse SC [15][16][17][18][19] , we find that visually responsive neurons are located in both the superficial and deep SC while auditory responsive neurons are found only in the deep (≳ 400 µm) SC. Fig.…”

Section: Resultssupporting

confidence: 88%

“…c: Reconstructed 2D map of all the cells with visual and/or auditory responses (blue: visual, red: auditory, yellow: bimodal, black: non-responsive; significant response with p < 0.001; quasi-Poisson statistics 17 )…”

Section: Resultsmentioning

confidence: 99%

“…Virtual auditory space stimulation for mice was done in an anechoic chamber as previously described 17 . Briefly, sound is produced through earphones that are placed near the mouse’s pinnae.…”

Section: Methodsmentioning

confidence: 99%

“…Animal preparation, head plate attachment and craniotomy were performed as previously described 17 . We used 2-9 month-old CBA/CaJ (The Jackson Laboratory, 000654) mice of each sex.…”

Section: Animal Preparation For Electrophysiologymentioning

confidence: 99%

“…3 (one per stim location) Individual (0-100) Hz (-100-200) Hz Fitting procedure of the multisensory model A maximum-likelihood method was used to fit our model to the data. The likelihood function-deviance ( : twice the negative log-likelihood ratio)-for one neuron is defined based on D quasi-Poisson statistics 17,42,43 as follows.…”

Section: Model Of Multisensory Responsesmentioning

confidence: 99%

See 4 more Smart Citations

Nonlinear visuoauditory integration in the mouse superior colliculus

Ito

Litke

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Sensory information from different modalities is processed in parallel, and then integrated in associative brain areas to improve object identification and the interpretation of sensory experiences. The Superior Colliculus (SC) is a midbrain structure that plays a critical role in integrating visual, auditory, and somatosensory input to assess saliency and promote action. Although the response properties of the individual SC neurons to visuoauditory stimuli have been characterized, little is known about the spatial and temporal dynamics of the integration at the population level. Here we recorded the response properties of SC neurons to spatially restricted visual and auditory stimuli using large-scale electrophysiology. We then created a general, population-level model that explains the spatial, temporal, and intensity requirements of stimuli needed for sensory integration. We found that the mouse SC contains topographically organized visual and auditory neurons that exhibit nonlinear multisensory integration. We show that nonlinear integration depends on properties of auditory but not visual stimuli. We also find that a heuristically derived nonlinear modulation function reveals conditions required for sensory integration that are consistent with previously proposed models of sensory integration such as spatial matching and the principle of inverse effectiveness.

show abstract

Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Animal preparation, head plate attachment and craniotomy were performed as previously described 17 . We used 2-9 month-old CBA/CaJ (The Jackson Laboratory, 000654) mice of each sex.…”

Section: Animal Preparation For Electrophysiologymentioning

confidence: 99%

Section: Model Of Multisensory Responsesmentioning

confidence: 99%

See 3 more Smart Citations

Nonlinear visuoauditory integration in the mouse superior colliculus

Ito

Litke

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Restricted Auditory Aspatialism

Wadle¹

2021

The British Journal for the Philosophy of Science

View full text Add to dashboard Cite

Some philosophers have argued that we do not hear sounds as located in the environment.Others have objected that this straightforwardly contradicts the phenomenology of auditory experience. And from this they draw metaphysical conclusions about the nature of soundsthat they are events or properties of vibrating surfaces rather than waves or sensations. I argue that there is a minimal, but recognizable, notion of audition to which this phenomenal objection does not apply. While this notion doesn't correspond to our ordinary notion of auditory experience, it does-in conjunction with our lack of an uncontroversial individuation of the senses and recent interest in distinctively multisensory features of perceptual experiences-raise the possibility of more expansive notions of audition, including some that do plausibly count as corresponding to our everyday notion of audition, that lack the spatial phenomenology cited in the objection. Until this possibility is ruled out, the phenomenal objection and metaphysical conclusions drawn from it remain inconclusive. argued that we do not enjoy spatial audition-that is, we do not hear sounds as located in the environment, even in the bare sense of merely off in a given direction or at some particular distance

show abstract

Open source silicon microprobes for high throughput neural recording

Yang¹,

Lee²,

Villagracia³

et al. 2020

J. Neural Eng.

View full text Add to dashboard Cite

Objective.-Microfabricated multielectrode arrays are widely used for high throughput recording of extracellular neural activity, which is transforming our understanding of brain function in health and disease. Currently there is a plethora of electrode-based tools being developed at higher education and research institutions. However, taking such tools from the initial research and development phase to widespread adoption by the neuroscience community is often hindered by several obstacles. The objective of this work is to describe the development, application, and open dissemination of silicon microprobes for recording neural activity in vivo.Approach.-We propose an open source dissemination platform as an alternative to commercialization. This framework promotes recording tools that are openly and inexpensively available to the community. The silicon microprobes are designed in house, but the fabrication and assembly processes are carried out by third party companies. This enables mass production, a key requirement for large-scale dissemination.Main results.-We demonstrate the operation of silicon microprobes containing up to 256 electrodes in conjunction with optical fibers for optogenetic manipulations or fiber photometry. These data provide new insights about the relationship between calcium activity and neural spiking activity. We also describe the current state of dissemination of these tools. A file repository of resources related to designing, using, and sharing these tools is maintained online.Significance.-This paper is likely to be a valuable resource for both current and prospective users, as well as developers of silicon microprobes. Based on their extensive usage by a number of labs including ours, these tools present a promising alternative to other types of electrode-based technologies aimed at high throughput recording in head-fixed animals. This work also demonstrates the importance of validating fiber photometry measurements with simultaneous electrophysiological recordings.

show abstract

Spectral cues are necessary to encode azimuthal auditory space in the mouse superior colliculus

Cited by 5 publications

References 49 publications

Nonlinear visuoauditory integration in the mouse superior colliculus

Nonlinear visuoauditory integration in the mouse superior colliculus

Restricted Auditory Aspatialism

Open source silicon microprobes for high throughput neural recording

Contact Info

Product

Resources

About