Spectral, DFT—TDDFT computational investigation and biological studies of transition metal complexes of dehydroacetic acid schiff base

Kashar, Tahani I.; Aal, S. Abdel

doi:10.1007/s13738-020-02134-3

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…The range of moments for tetrahedral cobalt (II) complexes is 4.26-5.00 BM [33] values of 4.92, 4.65 and 4.28 BM presented for the magnetic moments of B1, B2 and B3 cobalt complexes respectively are within the expected range for mononuclear tetrahedral complexes [34][35][36][37]. 3.…”

Section: Electronic Absorption Data and Magnetic Susceptibility Measu...mentioning

confidence: 71%

Antibacterial potentials and DNA study of cobalt(II) complexes containing aminophenol Schiff base moiety

Ejiah,

Fasina,

Revaprasadu

et al. 2024

LJSIR

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The present study was carried out to investigate the effect of substituent groups on the antibacterial activities of 2-aminophenol Schiff bases and their cobalt (II) complexes. Development of new compounds with potential effects against pathogenic organisms has become necessary due to the increase in microbial resistance reported for existing antiseptics and disinfectants. In line with this, new cobalt (II) complexes with Schiff bases derived from 2-aminophenol and p-substituted benzaldehydes were synthesized. The compounds were characterized using elemental analysis, mass spectrometry, atomic absorption spectroscopy, electrospray ionization mass spectrometry, infrared spectroscopy, 1H NMR and electronic absorption spectroscopy. Results indicate that all metal complexes had a 1:2 metal ligand ratio with magnetic moments characteristic of tetrahedral geometry around the metal ion. The Schiff bases and their metal complexes were screened for in-vitro antibacterial activities against 6 human pathogenic bacteria usually found around the hospitals and homes; Escherichia coli (ATCC 8739), Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 19582), Bacillus cereus (10702), Enterococcus faecalis (ATCC 29212) and Kribsella pneumonia (ATCC 10031) with ampicillin used as the reference compound. DNA binding study using calf thymus DNA revealed intercalative mode of activity. The result showed that Schiff bases exhibited moderate inhibitory activity against the tested microorganisms while Schiff base metal complexes exhibited higher antibacterial activity when compared to ampicillin. Our results indicate that these complexes can be employed as active ingredients in development of broad-spectrum antibacterial agents.

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Section: Electronic Absorption Data and Magnetic Susceptibility Measu...mentioning

confidence: 71%

Antibacterial potentials and DNA study of cobalt(II) complexes containing aminophenol Schiff base moiety

Ejiah,

Fasina,

Revaprasadu

et al. 2024

LJSIR

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Copper catalysts supported by dehydroacetic acid chitosan schiff base for CuAAC click reaction in water

Asadi,

Bahramian,

Dehno Khalaji

et al. 2024

Cellulose

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Cytotoxic ROS-Consuming Mn(III) Synzymes: Structural Influence on Their Mechanism of Action

Verderi,

Nova,

Borghesani

et al. 2024

IJMS

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ROS (i.e., reactive oxygen species) scavenging is a key function of various Mn-based enzymes, including superoxide dismutases (SODs) and catalases, which are actively linked to oxidative stress-related diseases. In this study, we synthesized and characterized two novel Mn(III)-based synzymes (i.e., synthetic enzymes), designated C1 ([MnL1Cl(H2O)]Cl·3H2O) and C2 ([MnL2Cl2]·2H2O), which differ in the presence of a bridging aliphatic or aromatic group in the chelator. Using a range of analytical techniques, we found that the aromatic C2 bridge significantly influences the Mn(III) center’s cis-β configuration, unlike C1, which adopts a trans configuration. We then thoroughly evaluated the oxidation-reduction properties of C1 and C2, including their redox potentials (by cyclic voltammetry) and capacity to consume various ROS species (using DPPH, hydroxyl radical, hydrogen peroxide, and superoxide UV–visible spectrophotometric assays). The specific kinetics of the H2O2 dismutation process, as measured by a Clark-type electrode and time-resolved ESI-MS, revealed that both synzymes possess catalytic activity. Toxicological experiments using the Galleria mellonella larval model demonstrated the compounds’ innocuous nature towards higher eukaryotic organisms, while cytotoxicity assays confirmed their selective efficacy against lung cancer cells. Additional cytological assays, such as the thiobarbituric acid reactive substances assay and caspase-3 activity and p53 expression analysis, reported that C1 and C2 induce cytotoxicity against cancer cells via apoptosis rather than necrosis and behave very differently towards redox substances and ROS-regulating enzymes in vivo. These findings suggest that the structural differences between C1 and C2 lead to distinct redox properties and biological activities, highlighting the potential of these novel Mn(III)-based synzymes as therapeutic agents for the treatment of oxidative stress-related diseases, particularly lung cancer. Further studies are warranted to elucidate the underlying mechanisms of action and explore their clinical applications.

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Spectral, DFT—TDDFT computational investigation and biological studies of transition metal complexes of dehydroacetic acid schiff base

Cited by 3 publications

References 42 publications

Antibacterial potentials and DNA study of cobalt(II) complexes containing aminophenol Schiff base moiety

Antibacterial potentials and DNA study of cobalt(II) complexes containing aminophenol Schiff base moiety

Copper catalysts supported by dehydroacetic acid chitosan schiff base for CuAAC click reaction in water

Cytotoxic ROS-Consuming Mn(III) Synzymes: Structural Influence on Their Mechanism of Action

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