Spectral displacement techniques for studying the binding of spectroscopically transparent ligands to cyclodextrins

The binding interaction of synthetic ozonide antimalarials with natural and modified β-cyclodextrins

“…b-CD was also used in preference to (SBE) 7 -b-CD in NMR studies as the presence of randomly substituted sulfobutylether chains on (SBE) 7 -b-CD prohibited assignment of individual chemical shifts within the NMR spectra. Studies with b-CD and two other non-OZ adamantane derivatives (1-adamantanamine and 1-adamantanecarboxylic acid) were performed to validate the current titration method and the data were consistent with published binding data determined using non calorimetric methods 13,14 (Tab. 2).…”

“…2). The anticipated binding constant for the interaction between compounds of the OZ series and b-CD derivatives was of the order 10 4 /M based on values reported for adamantane derivatives, 13 cyclohexane derivatives (10 3 / M) 14 and other endoperoxides (10 2 -10 3 /M). [15][16][17][18][19] NMR and molecular dynamics results from these studies indicated minimal involvement of the endoperoxide ring with the cyclodextrin cavity, suggesting only weak binding at the face of the cyclodextrin cavity rather than formation of a true inclusion complex.…”

Supramolecular Complex Formation: A Study of the Interactions between β‐Cyclodextrin and Some Different Classes of Organic Compounds by ESI‐MS, Surface Tension Measurements, and UV/Vis and 1H NMR Spectroscopy

“…A typical example is shown in Figure 8. UV/Vis Measurements: A spectroscopic displacement technique [29,37] was used to determine the binding constants (1:1 complexes) of the spectroscopically transparent (250Ϫ600 nm) guests described above with β-CD.…”

Supramolecular Polymeric Hydrogels for Ultrasound‐Guided Protein Release

“…To make the supramolecular hydrogel as strong as possible, Ad was selected as the guest moiety due to the strong interaction with β‐CyD . Although the interaction between β‐CyD and Ad is one of the strong host–guest interactions, their binding constant was reported to be 4.2 × 10 4 m −1 . From the value, the standard free energy of their interaction is simply estimated to be 26 kJ mol −1 .…”