Spectral domain optical coherence tomography findings in retinal folds associated with posterior microphthalmos

Jackson, Thomas E.; Yang, Yit; Shun-Shin, G A

doi:10.1016/j.jaapos.2012.02.020

Cited by 12 publications

(10 citation statements)

References 5 publications

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“…The present results are consistent with those described in previous SD-OCT studies on PM. [18][19][20][21] As previously reported, intraretinal cystoid spaces involving the retinal papillomacular fold area were identified. 18,19 In eyes with PM, the foveal dip was absent and the inner retinal layers were thicker than the outer retinal layers.…”

Section: Discussionmentioning

confidence: 65%

“…[18][19][20][21] As previously reported, intraretinal cystoid spaces involving the retinal papillomacular fold area were identified. 18,19 In eyes with PM, the foveal dip was absent and the inner retinal layers were thicker than the outer retinal layers. The retinal papillomacular fold was noted only in one meridian while the meridian perpendicular to it did not show the elevated retinal papillomacular fold.…”

Section: Discussionmentioning

confidence: 79%

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Retinal structural and vascular changes in posterior microphthalmos

Venkatesh

Jain

Srinivasan

et al. 2020

Clinical and Experimental Optometry

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Background Posterior microphthalmos (PM) is a rare developmental disorder characterised by high hyperopia, short axial length, presence of retinal papillomacular fold and relatively normal anterior segment findings. The study objective is to describe the retinal structural and vascular changes in eyes with PM with spectral domain optical coherence tomography, optical coherence tomography angiography and multicolour imaging. Methods In this retrospective, comparative case series, 10 eyes of five patients with PM as cases and 10 eyes of five age‐ and sex‐matched controls were included. Structural changes, namely inner and outer retinal layer thicknesses, were measured using optical coherence tomography. Multicolour imaging findings were noted. Perifoveal vascular changes with qualitative and quantitative assessments were analysed using optical coherence tomography angiography. Results The foveal dip was absent in all 10 eyes (100 per cent) with PM. There was an elevated retinal papillomacular fold in six eyes (60 per cent) and intraretinal cystoid spaces in two eyes (20 per cent) with PM. The inner retinal layers were thicker in PM. On multicolour imaging, foveal avascular zone and retinal wrinkles were identified in eyes with retinal papillomacular fold in blue and green reflectance images. Perifoveal vascular changes in optical coherence tomography angiography included foveal area size reduction in superficial and deep vascular networks. The foveal capillary vessel densities were higher in PM compared to the controls in both superficial (46.3 ± 3.7 per cent; p = 0.000) and deep (54.7 ± 3.5 per cent; p = 0.000) capillary plexuses. Flow areas in superficial (p = 0.693) and deep (p = 0.088) capillary plexuses were not statistically relevant. Conclusion The study suggests that in PM, retinal foreshortening occurs in one meridian leading to secondary changes such as loss of foveal dip, posterior bowing of the outer layers of the eye, thickening of the inner retina and ultimately, retinal papillomacular fold formation. The findings of the study need further validation in a larger series of patients with PM.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 79%

Retinal structural and vascular changes in posterior microphthalmos

Venkatesh

Jain

Srinivasan

et al. 2020

Clinical and Experimental Optometry

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“…Papillomacular fold is an ocular finding in posterior microphthalmia and is considered one of the causes of reduced vision. It is confined only to the neurosensory layer sparing the retinal pigment epithelium, choroid, and sclera [13]. It is important for the ophthalmologist to be aware of this finding as this can be confused or mistaken as cystoid macular edema [14].…”

Section: Discussionmentioning

confidence: 99%

Posterior Microphthalmia, Peripheral Pigmentary Retinal Changes, Yellow Lesions, and Cleft Lip: A Case Report and Literature Review

Alsaedi

Alrubaie

2019

Case Reports in Ophthalmological Medicine

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Purpose. Posterior microphthalmia is a sporadic or inherited developmental ocular anomaly that may occur isolated or in association with multiple ocular and systemic anomalies. This report documents a case of posterior microphthalmia with atypical presentation including white dots in the posterior pole in addition to systemic anomalies including facial defect that can represent an underlying genetic mutation. Method. Case report. Results. A 29-year-old male with high hyperopia and history of bilateral clear lens presented with pigmentary changes and white-yellow dots in the posterior pole in both eyes. Patient had a history of cleft lip repair. A complete ocular evaluation including A/B scan and optical coherence tomography confirmed the diagnosis of posterior microphthalmia with a retinitis pigmentosa like fundus and drusen deposits in the subretinal pigment epithelium. Conclusion. The white-yellow drusenoid deposits in the posterior pole in association with posterior microphthalmia are poorly documented in the literature. Cases of craniofacial developmental defects in association with posterior microphthalmia may represent a genetic defect.

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“…The thickened sclera is commonly found in microphthalmos and nanophthalmos and contributes to retinal features such as absent foveal pit, diffuse macular thickening, rudimentary foveal avascular zone, schisis of the retinal layers, and macular cysts. 7 Although the retinal changes were similar to nanophthalmos the eyes had normal iridocorneal angle, axial length, and absence of hypermetropia. Individuals with MSS have a short life span and knowledge about ophthalmic and systemic features is constantly evolving.…”

Section: Discussionmentioning

confidence: 91%