Spectral Domain Optical Coherence Tomography Findings in Coats Disease

Abstract

Spectral domain OCT can identify microstructural abnormalities in Coats disease that are associated on univariate analysis with worse baseline visual acuity and visual prognosis. Further larger studies are necessary.

Multimodal Imaging of Adult-onset Coats’ Disease

“…An understanding of the SD-OCT findings in these cases benefits from the recent work elucidating the ways SD-OCT can augment the diagnosis and inform the prognosis in Coats' disease. [11,12] The significant outer retinal atrophy over the foveal fibrotic nodule in our first case is an SD-OCT finding that Ong et al noted is often underappreciated on clinical examination. [11] Their study noted that subretinal fluid, multilayered exudates, retinal rosettes, and intraretinal vessels to fibrotic nodules were other microstructural features revealed on SD-OCT. Gupta et al similarly reported the ability of SD-OCT to detect microstructural features not evident on clinical examination and also studied the link of SD-OCT findings to visual prognosis.…”

“…[11] Their study noted that subretinal fluid, multilayered exudates, retinal rosettes, and intraretinal vessels to fibrotic nodules were other microstructural features revealed on SD-OCT. Gupta et al similarly reported the ability of SD-OCT to detect microstructural features not evident on clinical examination and also studied the link of SD-OCT findings to visual prognosis. [12] Ellipsoid zone (EZ) and external limiting membrane (ELM) disruption on SD-OCT most significantly affected pre-and post-treatment visual prognosis, with subfoveal nodules, subretinal exudates, and subretinal fluid also serving as negative prognostic visual factors. The ability of SD-OCT to inform visual prognosis by these findings is most relevant to our first case, where the large subfoveal nodule with overlying loss of the EZ and ELM renders a patient with Stage 2B disease a far worse prognosis than a typical patient with Stage 3A disease with intact foveal laminations.…”

Imaging Findings and Long-Term Treatment Outcomes in Coats’ Disease

“…Son yıllarda hastalığın takibinde ve prognozun belirlenmesinde OKT'nin kullanımı yaygınlaşmıştır (1,8) . OKT görüntüleri ile hastaların biyomikroskopik fundus muayenelerinde belirlenemeyen bulgular ortaya konabildiği gibi, tedavi cevabı da kantitatif olarak değerlendirilebilir (14,15) . Ong ve ark.…”

Factors Predictive of Subretinal Fluid Resolution in Coats Disease: Analysis of 177 Eyes in 177 Patients at a Single Center

“…A comparison (high vs low RD) regarding visual acuity outcomes revealed 20/50 or better (17% vs 27%), 20/60 to 20/200 (17% vs. 9%), and worse than 20/200 (66% vs 64%) indicating reduced visual prognosis for eyes with high RD. 9 Gupta et al 10 in a review of spectral domain optical coherence tomography (SD-OCT) features of 27 cases of Coats disease found macular SRF in 10 eyes (37%), which was associated with worse baseline and final visual acuity. Previous reports from our center 4,6 on the correlation between disease staging and visual outcome found that increasing disease severity was associated with poorer visual outcome (20/200 or worse).…”