Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer Thickness in NMO Patients

Lange, Alex P.; Sadjadi, Reza; Zhu, Feng; Alkabie, Samir; Costello, Fiona; Traboulsee, Anthony

doi:10.1097/wno.0b013e31829c510e

Cited by 47 publications

(42 citation statements)

References 18 publications

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“…However, Lange et al. () found that NMOSD‐ON patients did not have significantly thinner pRNFL than MS‐ON patients (63.7 versus 73.9 μ m, p = 0.56) in a study analysing the subset of patients with one ON episode. In addition, Outteryck et al.…”

Section: Discussionmentioning

confidence: 95%

Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode

Peng

Wang

et al. 2016

Acta Ophthalmologica

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Section: Discussionmentioning

confidence: 95%

Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode

Peng

Wang

et al. 2016

Acta Ophthalmologica

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“…In the past 15 years, the potential role of optical coherence tomography (OCT) measurements as biomarkers of disease progression in neurodegenerative disorders, particularly multiple sclerosis, Alzheimer's disease, neuromyelitis optica and Parkinson's disease, has been widely investigated [14][15][16][17][18][19][20][21][22][23][24]. OCT measurements are frequently used in observational studies, clinical practice and, more recently, therapeutic trials, with the number of studies in this area increasing exponentially over the last 5 years [21,25].…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography findings in Huntington’s disease: a potential biomarker of disease progression

et al. 2015

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Previous reports of ocular abnormalities in Huntington's disease (HD) have detailed eye movement disorders. The objective of this case-control study was to investigate optic nerve and macular morphology in HD using optical coherence tomography (OCT). A total of 26 HD patients and 29 controls underwent a thorough ophthalmic examination including spectral domain OCT scans of the macula and peripapillary retinal nerve fibre layer (RNFL). Genetic testing results, disease duration, HD disease burden scores and Unified HD Rating Scale motor scores were acquired for HD patients. Temporal RNFL thickness was significantly reduced in the HD group (62.3 vs. 69.8 μm, p = 0.005), and there was a significant negative correlation between temporal RNFL thickness and disease duration (R (2) = -0.51, p = 0.04). Average peripapillary RNFL thickness was not significantly different between the HD and control groups. There was a significant negative correlation between macular volume and disease duration (R (2) = -0.71, p = 0.002), and motor scores (R (2) = -0.56, p = 0.01). Colour vision was significantly poorer in the HD group. Temporal RNFL is preferentially thinned in HD patients, possibly implicating mitochondrial dysfunction as the temporal RNFL is reduced in the patients with some mitochondrial disorders, including Leber's hereditary optic neuropathy. The correlation between the decrease in macular volume and temporal RNFL, and increasing disease severity suggests that OCT may be a useful biomarker for disease progression in HD. Larger, longitudinal studies are required.

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“…Patients with NMO are, however, more likely to have bilateral optic neuritis at presentation and to present with worse visual acuities 18. There is a suggestion that there is greater thinning of the retinal nerve fibre layer in NMO on optical coherence tomography but this difference does not separate the conditions clinically at the time of presentation 23 24…”

Section: Mimicsmentioning

confidence: 99%

Mimics and chameleons of optic neuritis

Weerasinghe

Lueck

2016

Pract Neurol

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Optic neuritis is a common problem and most neurologists are familiar with it. Recent studies have suggested that it can be overdiagnosed in as many as 10% of cases. The major reasons for this relate to confusion regarding terminology and lack of familiarity with common mimics. This article covers typical 'idiopathic' demyelinating optic neuropathy (IDON) and several possible variations in the way it can present (chameleons). We then discuss several conditions that can mimic IDON, including neuromyelitis optica, sarcoidosis, chronic relapsing inflammatory optic neuropathy, anterior ischaemic optic neuropathy, infectious/parainfectious optic neuropathy, neuroretinitis, Leber's hereditary optic neuropathy, and some 'ocular' mimics including autoimmune retinopathy and central serous choroidoretinopathy.

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Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer Thickness in NMO Patients

Abstract: RNFL in NMO is not different enough to distinguish NMO ON from MS ON eyes, but the intereye difference in RFNL with a history of unilateral ON may be a better diagnostic marker for NMO.

Cited by 47 publications

References 18 publications

Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode

Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode

Optical coherence tomography findings in Huntington’s disease: a potential biomarker of disease progression

Mimics and chameleons of optic neuritis

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