Spectral energy effects in ESR bone dosimetry: Photons and electrons

Copeland, J.F.; Kase, Kenneth R.; Chabot, G.E.; Greenaway, Frederick T.; Inglis, George B.

doi:10.1016/0969-8043(93)90204-n

Cited by 14 publications

(5 citation statements)

References 10 publications

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“…These variations in bone composition and density of the bone sample strongly impact the dose deposition measured on our tibia bones. Moreover, experimental (EPR) or calculated studies on the effects of different qualities of X-rays have highlighted the dose enhancement on bone tissues at low energy and also the importance of taking into account the bone composition in the calculation of the absorbed dose ( Copeland et al, 1993 ; Johnson et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Preclinical modeling of low energy X-rays radiological burn: Dosimetry study by monte carlo simulations and EPR spectroscopy

et al. 2022

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Interventional radiology has grown considerably over the last decades and become an essential tool for treatment or diagnosis. This technique is mostly beneficial and mastered but accidental overexposure can occur and lead to the appearance of deterministic effects. The lack of knowledge about the radiobiological consequences for the low-energy X-rays used for these practices makes the prognosis very uncertain for the different tissues. In order to improve the radiation protection of patients and better predict the risk of complications, we implemented a new preclinical mouse model to mimic radiological burn in interventional radiology and performed a complete characterization of the dose deposition. A new setup and collimator were designed to irradiate the hind legs of 15 mice at 30 Gy in air kerma at 80 kV. After irradiation, mice tibias were collected to evaluate bone dose by Electron Paramagnetic Resonance (EPR) spectroscopy measurements. Monte Carlo simulations with Geant4 were performed in simplified and voxelized phantoms to characterize the dose deposition in different tissues and evaluate the characteristics of secondary electrons (energy, path, momentum). 30 mice tibias were collected for EPR analysis. An average absorbed dose of 194.0 ± 27.0 Gy was measured in bone initially irradiated at 30 Gy in air kerma. A bone to air conversion factor of 6.5 ± 0.9 was determined. Inter sample and inter mice variability has been estimated to 13.9%. Monte Carlo simulations shown the heterogeneity of the dose deposition for these low X-rays energies and the dose enhancement in dense tissue. The specificities of the secondary electrons were studied and showed the influence of the tissue density on energies and paths. A good agreement between the experimental and calculated bone to air conversion factor was obtained. A new preclinical model allowing to perform radiological burn in interventional radiology-like conditions was implemented. For the development of new preclinical radiobiological model where the exact knowledge of the dose deposited in the different tissues is essential, the complementarity of Monte Carlo simulations and experimental measurements for the dosimetric characterization has proven to be a considerable asset.

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Section: Discussionmentioning

confidence: 99%

Preclinical modeling of low energy X-rays radiological burn: Dosimetry study by monte carlo simulations and EPR spectroscopy

et al. 2022

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“…9. The dose deposition in B88 for photons with energy below about 100 keV is dominated by the [19,20]. The mass energy absorption coefficient (μ en /ρ) (cm 2 g À 1 ) for (B88) was calculated using the following equation [21]:…”

Section: Energy Dependencementioning

confidence: 99%

Nano-barium–strontium sulfate as a new thermoluminescence dosimeter

Aboelezz

Sharaf

Hassan

et al. 2015

Journal of Luminescence

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“…Studies of the basic nature of the ESR signal from irradiated proteins and biological crystals also proceeded in various laboratories (6,7,49-52). Separation of the contributions from diagnostic X-rays and high energy y rays to the ESR signal in dental enamel and proper account of the mass-energy attenuation coefficient were investigated by Aldrich and Pass (18) and then elaborated on by other groups (53)(54)(55). This separation uses the dependence of attenuation of absorbed dose across the width of a tooth on energy of the incident radiation.…”

Section: Biophysical Dosimetry Using Electron Spin Resonance In Biolomentioning

confidence: 99%

Collective radiation biodosimetry for dose reconstruction of acute accidental exposures: a review.

Pass

1997

Environ Health Perspect

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Quantification of the biologically relevant dose is required to establish cause and effect between radiation detriment or burden and important biological outcomes. Most epidemiologic studies of unanticipated radiation exposure fail to establish cause and effect because researchers have not been able to construct a valid quantification of dose for the exposed population. However, no one biodosimetric technique (biophysical or biological) meets all the requirements of an ideal dosimeter. This paper reviews how the collection of biodosimetric data for victims of radiation accidents can be used to create a dosimetric "gold standard." Particular emphasis is placed on the use of electron spin resonance, a standard for radiation accident dosimetry. As an example of this technique, a review will be presented of a previously reported study of an individual exposed to a 60Co sterilization source.

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Spectral energy effects in ESR bone dosimetry: Photons and electrons

Cited by 14 publications

References 10 publications

Preclinical modeling of low energy X-rays radiological burn: Dosimetry study by monte carlo simulations and EPR spectroscopy

Preclinical modeling of low energy X-rays radiological burn: Dosimetry study by monte carlo simulations and EPR spectroscopy

Nano-barium–strontium sulfate as a new thermoluminescence dosimeter

Collective radiation biodosimetry for dose reconstruction of acute accidental exposures: a review.

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