Spectral investigation of magnetite nanoparticles interaction with charged drugs

Vakula, Arthur; Bereznyak, E. G.; Gladkovskaya, N. A.; Dukhopelnikov, E. V.; Anastasiia, Herus; Tarapov, S. I.

doi:10.1109/msmw.2016.7538006

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…The FMR properties of Fe 1-x Co x Fe 2 O 4 nanoparticles were studied in the frequency band f   8…40 GHz at the temperature T  300 K. Each MNP sample enclosed in a spherical dielectric container was placed inside a tunable rectangular microwave cavity resonator [7,14] inserted between the poles of the electromagnet and connected to the spectrometer [10,15]. The MNP samples were examined in scanning mode by applying an external magnetic fi eld in the range H  0…10 kOe.…”

Section: Results and Discussion The Samples Of Fe 1-x Comentioning

confidence: 99%

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Ferromagnetic resonance in Fe1–xCoxFe2O4 nanoparticles precipitated from diethylene glycol

Vakula¹,

Kravchuk²,

Tarapov³

et al. 2020

RADIOFIZ. ELEKTRON.

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Ferromagnetic resonance in Fe 1-x Co x Fe 2 O 4 nanoparticles precipitated from diethylene glycol Subject and Purpose. One of the ways to gain in the effi ciency of the hyperthermia technique is through the synthesis of new magnetic nanomaterials off ering high coercive force without aff ecting biocompatibility. A proven technology is the doping of biocompatible materials, such as Fe 3 O 4 , with atoms of highly coercive substances, such as Co atoms. Despite it has been the theme of much investigation, magnetic state of such nanoparticles is still not completely understood. The present study is devoted to the magnetic and magnetic resonance properties of Fe 1-x Co x Fe 2 O 4 nanoparticles synthesized by the precipitation from diethylene glycol at two, T  200 °C and 500 °C, temperatures. The purpose is to study magnetic and magnetic resonance properties of Fe 1-x Co x Fe 2 O 4 nanoparticles at various concentrations x. Method and Methodology. The magnetometric method and the electron spin resonance method were employed to obtain, correspondingly, magnetic hysteresis loops of magnetic nanoparticles and ferromagnetic resonance (FMR) spectra in the frequency band f  8…20 GHz at the temperature T  294 K. Transmission electron microscopy was used for nanoparticle observations. Results. The analysis of the measuring results has shown that among Fe 1-x Co x Fe 2 O 4 nanoparticle samples with concentrations x  0.0, 0.5, and 1.0, the total magnetic anisotropy fi eld at x  0.5 is the largest of the three because its crystalline anisotropy fi eld is the largest compared to x  0.0 and 1.0. Conclusion. The presented results have advanced our understanding of the fundamental interaction between magnetic Co and Fe atoms inside the crystal lattice of AFe 2 O 4 , where A is Co or Fe. The gained knowledge can contribute to the development of magnetically controlled high-frequency fi lters and frequency selectors. Fig. 5. Table 1. Ref.: 19 items.

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Section: Results and Discussion The Samples Of Fe 1-x Comentioning

confidence: 99%

“…This approach does not aff ect the biocompatibility but improves the heating effi ciency of the magnetic nanoparticles. The necessary values, such as coercive force, , C H total magnetic anisotropy fi eld, , a H and magnetization, M, can be obtained from the ferromagnetic resonance (FMR) spectrum and from the shape of the magnetic hysteresis loop [9][10][11].…”

mentioning

confidence: 99%

Ferromagnetic resonance in Fe1–xCoxFe2O4 nanoparticles precipitated from diethylene glycol

Vakula¹,

Kravchuk²,

Tarapov³

et al. 2020

RADIOFIZ. ELEKTRON.

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“…Suspensions of SPION in water and water solution of sodium citrate (NaCit) with concentration C NaCit = 8×10 -4 M were used. The surface charge of bare iron oxide nanoparticles in water is slightly positive [10]. The coating of SPION by NaCit leads to the negative charge of their surface [11].…”

Section: Methodsmentioning

confidence: 99%

Interaction of superparamagnetic iron oxide nanoparticles with DNA and BSA

Skuratovska¹,

Pesina²,

Bereznyak³

et al. 2019

Biophysical Bulletin

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Background: Superparamagnetic iron oxide nanoparticles (SPION) are widely used in various biomedical technologies, in particular, as carriers for drug delivery to the target. Since SPION-drug complexes are planned to be used in vivo, it is necessary to find out if competitive binding of nanoparticles with biologically important macromolecules (nucleic acids and proteins) is possible. Objectives: To investigate the possibility of complexation of iron oxide nanoparticles with DNA and serum albumin. Materials and methods: Bare and sodium citrate coated SPION with different surface charges, bovine serum albumin (BSA) and calf thymus DNA were used. The complexes of SPION and macromolecules were precipitated by an external magnetic field. The research was carried out by spectrophotometry in visible and ultraviolet ranges. Results: To study SPION interactions with DNA and BSA, the spectra of supernatants of the binary systems were compared with the spectra of the corresponding control macromolecules solutions. In the DNA-SPION systems, a decrease in the DNA absorption is observed only for bare nanoparticles. Our estimation shows that the maximum possible concentration ratio of bound DNA to SPION is about 2.5×10-4 mol/g. The addition of sodium citrate coated SPION to the DNA solution does not cause any spectral changes of the supernatant. The interaction of BSA with SPION, coated with sodium citrate, leads to a slight increase in supernatant absorption compared with the one of the control protein solution. It can be caused by the fact that the resulting complexes are not precipitated by a magnetic field. No difference between the spectrum of the supernatant of BSA-bare SPION system and the control protein solution was observed. Conclusions: The obtained spectrophotometric results demonstrate the formation of complexes between DNA and bare iron oxide nanoparticles as well as between BSA and the nanoparticles, coated with sodium citrate. The maximum concentration ratio of bound DNA and bare SPION was obtained for the investigated system. It is necessary to take into account when SPION are used as carriers for drug delivery.

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Ferromagnetic resonance in the complex of Fe3O4 nanoparticles with organic compounds

Vakula¹,

Белоус²,

Kalmykova³

et al. 2017

RADIOFIZ. ELEKTRON.

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2Харьковский национальный университет радиоэлектроники 14, пр. Науки, Харьков, 61166, Украина 3 Институт общей и неорганической химии 32/34, бульвар Палладина, Киев, 03142, Украина 4 Харьковский национальный университет имени В. Н. Каразина 4, пл. Свободы, Харьков, 61022, Украина ФЕРРОМАГНИТНЫЙ РЕЗОНАНС В КОМПЛЕКСЕ Fe 3 O 4 НАНОЧАСТИЦ С ОРГАНИЧЕСКИМИ СОЕДИНЕНИЯМИКомплексы магнитных наночастиц с органическими молекулами вызывают большой интерес исследователей, поскольку обладают рядом уникальных свойств. Методика контроля состояния таких комплексов слабо развита. В данной работе с помощью ферромаг-нитного резонанса и электронно-микроскопических исследований осуществлен контроль состояния наночастиц, определяющий их магнитное взаимодействие. Показано, что органическое вещество образует оболочку вокруг наночастиц. В результате этого уменьшается диполь-дипольное взаимодействие между наночастицами в образце. Обнаружено, что степень диполь-дипольного взаимодействия между наночастицами определяется свойствами органического вещества. Подбором органического вещества мож-но контролировать магнитные свойства наночастиц. Ил. 2. Табл. 2. Библиогр.: 7 назв.Ключевые слова: магнитные наночастицы, ферромагнитный резонанс, конгломерат, диполь-дипольное взаимодействие, об-менное взаимодействие.Литературные источники описывают приме-нение магнитных наночастиц в медицине для ад-ресной доставки медпрепаратов [1, 2]. Однако после синтеза магнитные наночастицы без пред-варительной обработки образуют конгломераты и после помещения их в жидкость выпадают в оса-док. Эта особенность является нежелательной в случае применения их в медицине, так как обра-зование конгломерата может создать барьер в кровеносных сосудах с последующей гибелью живого организма. Во избежание процесса кон-гломерации наночастиц применяют стабилизацию путем добавления стабилизирующего вещества. Образованная таким образом взвесь чаще всего контролируется фотометрическим методом, кото-рый определяет лишь состояние стабилизатора. Такой метод контроля является косвенным, так как не определяет состояние наночастиц [3].Для контроля состояния наночастиц наиболее целесообразно использовать эффект ферромаг-нитного резонанса (ФМР). Известно, что при ФМР резонансное поле res H на заданной частоте f за-висит от полей диполь-дипольного и обменного взаимодействий [4, 5]. Эти два типа взаимодейст-вий зависят от расстояния между наночасти-цами [3][4][5][6], которое должно изменяться в зависи-мости от концентрации и типа стабилизатора. Изменение полей диполь-дипольного и обменно-го взаимодействий ведет к изменению значения резонансного поля res H при исследовании ФМР в наночастицах. Поэтому res H и форма пика ФМР для наночастиц, пребывающих в состоянии кон-гломерата, должны значительно отличаться от res H наночастиц в комплексе со стабилизатором. Целью работы является исследование ФМР в нано-частицах, пребывающих в комплексе с различ-ными органическими стабилизаторами.

show abstract

Spectral investigation of magnetite nanoparticles interaction with charged drugs

Cited by 5 publications

References 13 publications

Ferromagnetic resonance in Fe1–xCoxFe2O4 nanoparticles precipitated from diethylene glycol

Ferromagnetic resonance in Fe1–xCoxFe2O4 nanoparticles precipitated from diethylene glycol

Interaction of superparamagnetic iron oxide nanoparticles with DNA and BSA

Ferromagnetic resonance in the complex of Fe3O4 nanoparticles with organic compounds

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