Spectral Kinetic Method and Its Applications in the Evaluation of Gabapentin

Al-Salman, H. N. K.

doi:10.22377/ijgp.v12i04.2208

Cited by 7 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A symmetrical peak height is corresponding to the oxacillin concentration of standards and sample concentrations. [21][22][23][24]…”

Section: Methodsmentioning

confidence: 99%

Untitled

Al-Salman¹

2019

IJGP

View full text Add to dashboard Cite

Context: An accurate and sensitive high-performance liquid chromatography-ultraviolet (HPLC-UV) assay method was developed for the determination of two penicillins in oral dosage form to compare the amount of active ingredients of cloxacillin (drugs1) and flucloxacillin (drug 2). Objective: The objective of the study was to develop a simple, sensitive, accurate, and kinetic spectroscopic method for the measurement of two penicillins in the form of oxacillin sodium monohydrate in oral dosage pharmaceutical product. Materials and Methods: Monohydrate capsules (500 mg) were purchased from two different commercial companies and oxacillin sodium monohydrate analar was used as a test formulations. Oxacillin sodium monohydrate concentrations were analyzed by HPLC-UV system at λ = 230 nm. The separation was achieved using the Ion Pac zorbax 300-SCX Agilent Column, 5 µm, 4.6 × 250 mm. The mobile phase consisted of water:acetonitrile:methanol (40:30:30), all with 10 mM formic acid at pH = 4.8. The comparison study for the two pencillin formulations was assessed by calculating the peak height. The standard oxacillin sodium monohydrate and other pencillins were eluted at a flow rate of 1.0 ml/min. Results: The recoveries were ranged within 91.0-100% and the linearity were ranged (0.3-1.5) μg/ml, (n=5) with R 2 ≥ 0.9992 while the relative standard deviation were (RSD) ± 0.492-0.583 at room temperature 25°C. The detection lower limit of quantification was 4.44 µg/ml and lower limit of detection was 1.46 µg/ml. Conclusion: The proposed method was successfully applied to the determination of the drug in the pharmaceutical products and the validation of the statistical data. The results were compared to the reference method, and they showed good compatibility. There was no significant difference between the values detected by the new method and the classical method.

show abstract

“…A symmetrical peak height is corresponding to the oxacillin concentration of standards and sample concentrations. [21][22][23][24]…”

Section: Methodsmentioning

confidence: 99%

Untitled

Al-Salman¹

2019

IJGP

View full text Add to dashboard Cite

show abstract

“…The highest absorption peak due to the plasmon absorption band of the silver NPs colloid at 415 nm in the visible SPR region is obtained, which confirms the presence of silver NPs . The intense peak observed at 200 nm is attributed to the reducing agent GBP, which facilitates the reduction of Ag + to elemental silver NPs. The formation of silver NPs is shown in Figure b with an inset graph representing no change in the peak position with time between 0 and 100 min.…”

Section: Preparation and Characterization Of Silver Nanoparticlesmentioning

confidence: 99%

“…These nanoparticles are not like simple molecules; rather, they are composed of three different layers, viz., surface layer, shell layer, and core. They also exist in different shapes and sizes and can be free and composed of inorganic or organic moieties. − Due to their extremely small size and large surface-area-to-volume ratio, their physical and chemical properties vary in the surface and bulk with the same composition. They show a huge variation in their shape and size, due to which they exhibit a broad range of applications in different areas such as catalysis; biosensing; biological activity; drug delivery; electronics; and also in the field of medicine, pharmacy, and so on.…”

Section: Introductionmentioning

confidence: 99%

“…Since previous studies have revealed that the reductant can be of any nature, thus in the present investigation for the preparation of silver NPs, we have chosen a chemical reduction method for the synthesis of silver NPs in which neuroleptic drug gabapentin (GBP) was used as a reductant for the preparation of silver NPs. GBP is 1-(aminomethyl) cyclohexyl acetic acid having a chemical formula C 9 H 17 NO 2 , also known as cyclohexyl acetic acid, and an anticonvulsant drug having two functional groups, −NH 2 and −COOH. In the market, GBP is available under different brand names, such as Gralise, Neurontin, Fanatrex, and Horizant .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Detailed Kinetic and Mechanistic Study for the Preparation of Silver Nanoparticles by a Chemical Reduction Method in the Presence of a Neuroleptic Agent (Gabapentin) at an Alkaline pH and its Characterization

et al. 2022

View full text Add to dashboard Cite

For the very first time, a detailed kinetic study for the preparation of silver nanoparticles (silver NPs) by neuroleptic agent gabapentin (GBP) in the absence of a stabilizer has been reported in this investigation. This paper is devoted to the preparation of silver nanoparticles by a chemical reduction method in which gabapentin acts as both a reductant and a stabilizer, and AgNO3 is used as a source of Ag+ ions and NaOH for maintaining the alkaline medium. A UV–visible spectrophotometer is used to monitor the progress of the reaction kinetics in an aqueous medium by changing the concentration of different variables such as AgNO3, NaOH, and gabapentin at 40 °C. It is found that the reaction rate follows a pseudo-first-order reaction. The thermodynamic activation parameters were also studied at five different temperatures (303, 308, 313, 318, and 323 K) and used in the support of the proposed mechanistic scheme for the formation of silver nanoparticles. The prepared silver nanoparticles were characterized using different techniques: UV–visible spectrophotometry, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy, and powder X-ray diffraction. The average particle size was observed in the range of 5–45 nm.

show abstract

“…• Stock standard solutions of MET were prepared in acetonitrile: triethylamine 30:70 (v/v) + 0.5 M potassium dihydrogen orthophosphate buffer at pH 4.5 to prepare concentration of 1 mg/ml from MET. [29][30][31][32] • Working standard solutions of MET was prepared in acetonitrile: triethylamine 30:70 (v/v) + 0.5 M potassium dihydrogen orthophosphate buffer at pH 4.5 to prepare the concentration of 1.0, 2.0, 3.0, 4.0, and 5.0 µg/ml.…”

Section: Configure the Samples For Measurementmentioning

confidence: 99%

Untitled

Al-Salman¹

2019

IJGP

View full text Add to dashboard Cite

• A new method of estimating MET in pharmaceuticals. • Use of HPLC-UV technology for LC100 in the estimation of MET. • Study the structural synthesis of MET in the neutral, acidic and base. • Studying the relative stability of MET during the experimental estimation process. • Perform different applications for the purpose of validating the chromatographic method in the estimation of MET.

show abstract

Spectral Kinetic Method and Its Applications in the Evaluation of Gabapentin

Cited by 7 publications

References 17 publications

Untitled

Untitled

Detailed Kinetic and Mechanistic Study for the Preparation of Silver Nanoparticles by a Chemical Reduction Method in the Presence of a Neuroleptic Agent (Gabapentin) at an Alkaline pH and its Characterization

Untitled

Contact Info

Product

Resources

About