1998
DOI: 10.1016/s0378-5173(98)00221-x
|View full text |Cite
|
Sign up to set email alerts
|

Spectral properties and ion dissociation behavior of retinoids I.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
6
2

Year Published

2000
2000
2007
2007

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 12 publications
(8 citation statements)
references
References 21 publications
0
6
2
Order By: Relevance
“…This finding indicates that form II is the less stable at this temperature. Other authors,12 studying RA solubility in aqueous solutions (NaCl 0.15 M), found opposite results; it is important to bear in mind, however, that these authors employed a different analytical method, for which they did not report validation data, and using only aqueous solutions they assayed RA concentrations (1.2–1.9 µM) from 150 to 2600 times lower than those found in this study. Moreover, the DSC evaluation of phase changes in the recovered solids after their dissolution study also seems questionable.…”
Section: Resultscontrasting
confidence: 81%
See 1 more Smart Citation
“…This finding indicates that form II is the less stable at this temperature. Other authors,12 studying RA solubility in aqueous solutions (NaCl 0.15 M), found opposite results; it is important to bear in mind, however, that these authors employed a different analytical method, for which they did not report validation data, and using only aqueous solutions they assayed RA concentrations (1.2–1.9 µM) from 150 to 2600 times lower than those found in this study. Moreover, the DSC evaluation of phase changes in the recovered solids after their dissolution study also seems questionable.…”
Section: Resultscontrasting
confidence: 81%
“…In one the authors11 reported that the phase transition achieved by heating form I between 130 and 160°C produced a new form that was different from the known form II, but they did not attempt to identify it. In an earlier work, other authors12 established an energetic relationship between the monoclinic and triclinic forms that was inconsistent with the theory13,14 and our experimental evidence.…”
Section: Introductioncontrasting
confidence: 88%
“…3 It has been suggested that oral absorption of ATRA depends on the pH, the fatty acid composition, and the inherent bile salt solubilization capacity of the intestine. 6,7,28,29 In this study, the delayed absorption of ATRA observed in Group 1 could be explained by the slow solublization of ATRA in the weakly alkaline intestinal fluid. When ATRA was formulated as a HP␤CD complex for oral administration, the rate and extent of its absorption were improved substantially (Figure 2).…”
Section: Discussionmentioning
confidence: 64%
“…ATRA has almost nil aqueous solubility, 1 the problems of low water solubility and strong tendency to self-associate will pose great difficulties in formulating it into suitable oral and parenteral dosage forms. 28,29 As the oral absorption of most retinoids is increased with food, differing dietary regimens may contribute to the wide intra-and inter-patient variation in peak plasma ATRA concentrations reported in some studies. 3 It has been suggested that oral absorption of ATRA depends on the pH, the fatty acid composition, and the inherent bile salt solubilization capacity of the intestine.…”
Section: Discussionmentioning
confidence: 97%
“…This can be explained by the pK a value of retinoic acid, which is, for example, 6.05 in 150 mM NaCl and 6.49 in 5 mM NaCl. 26 Therefore, the anionic retinoic moieties within the complexes will be protonated at pH values lower than the pK a which lead to the cleavage of the ionic bonds in the complexes. The first experiments to evaluate the release properties of retinoic acid from thin films of the complexes were performed by using FTIR and surface tension measurements.…”
Section: Resultsmentioning
confidence: 99%