In December 2023, a 6.2 magnitude earthquake struck Jishishan, Gansu Province. This study utilized the Real‐time Earthquake Damage Assessment using City‐scale Time‐history analysis (RED‐ACT) system to analyze the seismic damage caused by the event. The analysis included assessments of strong ground motion records, building damage, and human acceleration feeling. The results indicate the following: (1) The earthquake‐induced significant ground motion. The response spectrum at the 0–1.3 s period range is far above the 7° design‐based and maximum considered earthquake levels, and it also far exceeds the 9° maximum considered earthquake level. How to provide a more scientific and reasonable seismic design standard to ensure the anti‐collapse performance of buildings still requires further in‐depth research. (2) The RED‐ACT analysis results indicate that the destructive power of this earthquake was significant. The strong ground motions recorded near the epicenter could cause a certain number of buildings to collapse, with the collapsed buildings mainly being raw‐earth/wood structures and unreinforced masonry structures. The main damage states of buildings assessed correspond generally with the actual earthquake damage survey results. (3) The RED‐ACT system can provide assessment results of human feeling of acceleration at different locations, and the assessment results take into account the amplification effect of acceleration by different floors, which can provide a reference for post‐earthquake science popularization and for reducing post‐earthquake panic among the population.