Spectroelectrochemical and computational studies of tetrahydrocannabinol (THC) and carboxy-tetrahydrocannabinol (THC-COOH)

Bindesri, Shruti D; Jebailey, Ricardo; Albarghouthi, Najwan; Pye, Cory C.; Brosseau, Christa L.

doi:10.1039/c9an02173f

Cited by 30 publications

(27 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A novel electrochemical roughening technique of commercial disposable electrodes of metallic surfaces such as gold and silver has been used to improve the reproducibility of the SERS substrate based on the deposition of nanostructures [ 34 , 35 , 36 , 37 ]. Additionally, screen-printed electrodes (SPE) have been recently reported as excellent substrates for SERS experiments [ 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy

González-Hernández

Ott

Arcos‐Martínez

et al. 2021

Sensors

View full text Add to dashboard Cite

The synthetic cathinones mephedrone (4-MMC) and 4-methylethcathinone (4-MEC) are two designer drugs that represent the rise and fall effect of this drug category within the stimulants market and are still available in several countries around the world. As a result, the qualitative and quantitative determination of ‘legal highs’, and their mixtures, are of great interest. This work explores for the first time the spectroelectrochemical response of these substances by coupling cyclic voltammetry (CV) with Raman spectroscopy in a portable instrument. It was found that the stimulants exhibit a voltammetric response on a gold screen-printed electrode while the surface is simultaneously electro-activated to achieve a periodic surface-enhanced Raman spectroscopy (SERS) substrate with high reproducibility. The proposed method enables a rapid and reliable determination in which both substances can be selectively analyzed through the oxidation waves of the molecules and the characteristic bands of the electrochemical SERS (EC-SERS) spectra. The feasibility and applicability of the method were assessed in simulated seized drug samples and spiked synthetic urine. This time-resolved spectroelectrochemical technique provides a cost-effective and user-friendly tool for onsite screening of synthetic stimulants in matrices with low concentration analytes for forensic applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Rapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy

González-Hernández

Ott

Arcos‐Martínez

et al. 2021

Sensors

View full text Add to dashboard Cite

show abstract

“…(C) EC-SERS for THC-COOH detection in urine samples from 0 V to −1.0 V (Reproduced from Ref. [ 111 ] with permission from the Royal Society of Chemistry.). (D) EC-SERS spectra for 6-TUA at different potentials and the comparison of SERS signals in synthetic urine and NaF (Reproduced with permission from Ref.…”

Section: Sers Detection Towards Metabolites In Biofluids and Tissuesmentioning

confidence: 99%

Human metabolite detection by surface-enhanced Raman spectroscopy

Liu

2022

Materials Today Bio

View full text Add to dashboard Cite

Metabolites are important biomarkers in human body fluids, conveying direct information of cellular activities and physical conditions. Metabolite detection has long been a research hotspot in the field of biology and medicine. Surface-enhanced Raman spectroscopy (SERS), based on the molecular “fingerprint” of Raman spectrum and the enormous signal enhancement (down to a single-molecule level) by plasmonic nanomaterials, has proven to be a novel and powerful tool for metabolite detection. SERS provides favorable properties such as ultra-sensitive, label-free, rapid, specific, and non-destructive detection processes. In this review, we summarized the progress in recent 10 years on SERS-based sensing of endogenous metabolites at the cellular level, in tissues, and in biofluids, as well as drug metabolites in biofluids. We made detailed discussions on the challenges and optimization methods of SERS technique in metabolite detection. The combination of SERS with modern biomedical technology were also anticipated.

show abstract

“…O processo de eliminação total pode demorar até 30 dias. Graças à sequestração e à existência de metabolitos ativos, é difícil compreender a relação entre a concentração de THC no plasma ou urina e a intoxicação (Bindesri et al, 2020).…”

Section: Tetra-hidrocanabinol (Thc)unclassified

Cannabis sativa e sua influência na capacidade de inteligência de seus usuários

Rodrigues

2022

RMd

View full text Add to dashboard Cite

Popularmente conhecida como maconha ou marijuana, Cannabis sativa apresenta compostos que podem ser utilizados como terapêuticos e substâncias que afetam o sistema nervoso e, devido a tal fato, é classificada como uma droga ilícita. A principal substância psicoativa da cannabis demonstra enorme influência no cérebro, o THC atinge o sistema nervoso central, reconhece receptores no local, se liga e essa ação é responsável por seus efeitos. Assim, o objetivo do presente estudo é compreender se indivíduos que fazem o uso recreativo da Cannabis sativa podem ser afetados na diminuição da inteligência e, portanto, parte-se de uma revisão de literatura, realizada por meio das seguintes bases de dados: SciELO, PubMed PsycINFO e Science Direct. Com o uso crônico da substância é possível desenvolver alguns efeitos maléficos na atenção, na função cognitiva, memória operacional e tais efeitos em conjunto dificultam o aprendizado do indivíduo.

show abstract

Spectroelectrochemical and computational studies of tetrahydrocannabinol (THC) and carboxy-tetrahydrocannabinol (THC-COOH)

Abstract: Electrochemical SERS allows for the rapid detection of both THC and THC-COOH in bodily fluid matrices without interferences from matrix species, paving the way to a point-of-need tool for cannabinoid detection.

Cited by 30 publications

References 31 publications

Rapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy

Rapid Determination of the ‘Legal Highs’ 4-MMC and 4-MEC by Spectroelectrochemistry: Simultaneous Cyclic Voltammetry and In Situ Surface-Enhanced Raman Spectroscopy

Human metabolite detection by surface-enhanced Raman spectroscopy

Cannabis sativa e sua influência na capacidade de inteligência de seus usuários

Contact Info

Product

Resources

About