Spectrofluorimetric assay of amlodipine and perindopril in their raw materials, pharmaceutical formulations and spiked human plasma through the formation of complexes with Eosin Y

Salem, Hesham; Abdelaziz, Amany; Derayea, Sayed M.; Nagy, Dalia M.; El‐Din, Khalid M. Badr

doi:10.1007/s11696-023-02668-9

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…The unique pharmacokinetic and pharmacodynamic characteristics of AMD seem to be linked to its physicochemical features, particularly its high degree of ionization and basicity [14]. Several methods have been conducted to determine AMD alone and with other drugs in its pure form and commercial samples: the redox titrimetric method [15], spectrophotometric methods [16][17][18], spectrofluorimetric methods [17,[19][20][21][22][23][24][25][26][27][28], high-performance liquid chromatography [29][30][31][32], thin layer chromatography [30], electroanalytical methods [31,33], and capillary electrophoretic methods [34,35]. Kokilambigai et al have provided a good review of the different analytical methods for determining AMD [36].…”

Section: Introduction and Prefacementioning

confidence: 99%

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Alqarni,

Haredy,

Abdelrahman

et al. 2024

Luminescence

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The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that several tools have been adopted as prospective measures of the method greenness. Fortunately, the established analytical method is identified as white by the white analytical chemistry (WAC) concept, which uses the red/ green/blue color scheme (RGB 12 tool) to combine ecological and functional factors for the first time in studying of the cited drug. Amlodipine (AMD), a cardiovascular treating agent, belongs to the dihydropyridine class of oral calcium channel‐blocking agents. This article presents a novel, simple, green, one‐pot‐processed, fast, and ultrasensitive fluorimetric approach for monitoring and assessment of AMD using molecular‐size‐dependent fluorescence augmentation of the light scattering‐driven signal of eosin, a biological stain at a wavelength of 415 nm. This enhancement was directly proportional to the size of the produced complex. The linearity range was from 30 to 900 ng mL−1, with corresponding sensitivity limits (detection and quantitation levels) of 9.2 and 28 ng mL−1, respectively. The planned approach was also successfully used to track AMD content in bulk, dosage forms, and bio‐fluids (human plasma and urine). The developed method's eco‐friendliness was established by different eco‐rating metric tools.

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Section: Introduction and Prefacementioning

confidence: 99%

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Alqarni,

Haredy,

Abdelrahman

et al. 2024

Luminescence

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Analysis of Two Oncological Drugs Futibatinib and Capivasertib via Ion‐Pairing With Eosin Y as a Spectrofluorimetric and Spectrophotometric Probe

Salem,

Emad,

El‐Araby

et al. 2024

Luminescence

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Using spectroscopy, two quick and sensitive analytical methods based on eosin Y ion pairing were developed and assessed in order to determine capivasertib and futibatinib with high selectivity and sensitivity. The quenching impact of futibatinib or capivasertib on the eosin Y's fluorescence at a pH 3.8 and 3.3 for futibatinib and capivasertib, respectively, in 0.1‐M acetate buffer solution was observed using two spectrofluorometric techniques. These techniques are regarded as the original spectrofluorometric techniques for the assay of futibatinib and capivasertib. For futibatinib and capivasertib, the quenching effect on fluorescence was ranged from 100 to 1000 and 150 to 1500 ng mL−1, respectively. The absorbance of the generated ion‐pair was measured using two different spectrophotometric methods at 550 nm in aqueous buffered solutions with pH values of 3.8 and 3.3 for futibatinib and capivasertib, respectively. In the concentration range of 1.0–10.0 and 2.0–10.0 μg mL−1, Beer's law was followed. The four approaches were applied to the analysis of dosage forms with a high percent recovery successfully, and they were assessed in compliance with ICH guidelines.

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Analysis of vericiguat via ion-pairing with eosin Y as a spectrofluorimetric and spectrophotometric probe: Application to content uniformity test

Salem,

Mazen,

Hany

et al. 2025

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Spectrofluorimetric assay of amlodipine and perindopril in their raw materials, pharmaceutical formulations and spiked human plasma through the formation of complexes with Eosin Y

Cited by 3 publications

References 39 publications

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Analysis of Two Oncological Drugs Futibatinib and Capivasertib via Ion‐Pairing With Eosin Y as a Spectrofluorimetric and Spectrophotometric Probe

Analysis of vericiguat via ion-pairing with eosin Y as a spectrofluorimetric and spectrophotometric probe: Application to content uniformity test

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