Spectrofluorimetric determination of amisulpride and bumidazone in raw materials and tablets

Abstract

A highly sensitive, simple and rapid spectrofluorimetric method was developed for the determination of amisulpride (AMS) and bumidazone (BUM) in tablet form. The proposed method is based on measuring the native fluorescence of the studied drugs in methanol at 360 and 344 nm after excitation at 276 and 232 nm for AMS and BUM, respectively. The fluorescence-concentration plots were rectilinear over the ranges of 5.0-60.0 ng/mL for AMS and 0.5-5.0 µg/mL for BUM. The lower detection limits were 0.70 ng/mL and 0.06 µg/mL, and the lower quantification limits were 2.0 ng/mL and 0.18 µg/mL for AMS and BUM, respectively. The method was successfully applied for the analysis of AMS and BUM in commercial tablets. Statistical evaluation and comparison of the data obtained using the proposed and comparison methods revealed good accuracy and precision for the proposed method.

NiFe-based Prussian blue analogue nanopolygons hybridized with functionalized glyoxal polymer as a voltammetric platform for the determination of amisulpride in biological samples

“…Literature has contained several analytical methods for determination of AMS in biological samples, most notably chromatographic [ 6 – 9 ], spectrophotometric [ 10 – 12 ], and spectrofluorometric [ 13 , 14 ]. Also, a few works based on electrochemical methods have been reported for AMS using ion-selective electrode [ 15 ] or unmodified glassy carbon electrode [ 16 ], and modified electrode with fsDNA [ 17 ], or ruthenium nanoparticles [ 18 ].…”

Green and sensitive detection of olopatadine in aqueous humor using a signal‐on fluorimetric approach: GREEnness assessment

“…Moreover, the utilization of micelle-induced fluorescence enhancement offers a versatile and effective means of exploring the characteristics and concentrations of various compounds [13,14]. Also, this technique continues to evolve, showing promise for broader applications in drug analysis, environmental studies, and biomedical research, underscoring its significance as a powerful tool in the field of analytical chemistry [15][16][17].…”

Amplified Electrochemiluminescence of the Luminol‐Amisulpride System and its Application for the Ultrasensitive Detection of Amisulpride

“…These significant clinical effects of AMS demonstrated that it has selective antagonistic effect on D 2 /D 3 dopaminergic receptors in the limbic system with little affinity to other dopamine receptors subtypes, muscarinic, serotonergic, α-adrenergic and histaminic receptors. [7] Up to now, different instrumental analytical methods have been reported for the analysis of AMS including spectrophotometry, [8] spectrofluorimetry, [9] high performance liquid chromatography (HPLC), [10] and electrochemistry. [11] The fluorescent methods require multi-step preparations of fluorescent probes and need external (excitation) light source.…”