Spectrofluorimetric determination of anthranilic acid derivatives based on terbium sensitized fluorescence

Ioannou, Penelope C.; Andrikopoulou, Dimitra A.; Glynou, Kiriaki M.; Tzompanaki, Georgia M.; Русакова, Н. В.

doi:10.1039/a806093b

Cited by 65 publications

(35 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21,61,62 In serum and urine, furosemide is the predominant species. 21,61 Taking into account the role of the 4-chloro-N-furfuryl-5-sulphamoyl-anthranilate ion (Fur) in the electrode response, along with the low concentration of acyl glucuronides in serum and urine, 21,61 no interference from these metabolites is expected in the determination of HFur in urine and human blood serum by the proposed sensor.…”

Section: Analytical Applicationmentioning

confidence: 99%

“…The amounts of HFur added to each biological fluid (urine and human blood serum) were those usually found after administration of a pharmaceutical dose. 21,28,[30][31][32]63,64 Commercial skimmed milk samples were spiked with HFur at a concentration level of 150 ng mL -1 and treated following the procedure described under "Determination of Furosemide in Commercial Milk Samples". This aforementioned concentration is the mean concentration of diurethic that can be detected in the next 8 h after administration of the usual 500 mg dosage of drug.…”

Section: Analytical Applicationmentioning

confidence: 99%

“…1, 2009 that permit the determination of this diuretic drug in pharmaceuticals and biological samples (milk, urine, plasma and serum). 11,12 These methods include spectrophotometry, [13][14][15][16][17][18] variable-angle scanning fluorescence spectrometry, 19 spectrofluorimetry, 20,21 diffuse reflectance spectroscopy, 22 potentiometry, 23 voltammetry, 24 chromatography, [25][26][27][28][29][30][31][32][33][34][35] capillary electrophoresis, [36][37][38][39] and flow-injection analysis. 40,41 However, many of these methods are often time-consuming, technically demanding and require the use of costly, highly specialized instruments.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Potentiometric sensor for furosemide determination in pharmaceuticals, urine, blood serum and bovine milk

Santini¹,

Pezza²,

Sequinel³

et al. 2009

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

A construção, avaliação e aplicação analítica de um sensor potenciométrico do tipo PtHgHg 2 (Fur) 2 Grafite, onde Fur significa íon 4-cloro-N-furfuril-5-sulfamoil-antranilato, são descritas. O eletrodo responde a Fur com sensibilidade de (−58,4 ± 0,9) mV década -1 no intervalo de 5,0 × 10 -7 -1,0 × 10 -2 mol L -1 , a pH 7,0-9,0 e com um limite de detecção de 3,8 × 10 -7 mol L -1 . O eletrodo é facilmente construído e de baixo custo, apresenta um rápido tempo de resposta (10-20 s) e pode ser usado por um período de 6 meses sem qualquer variação considerável nas suas características de desempenho. O eletrodo proposto mostrou boa seletividade na presença de várias substâncias, bem como na presença de alguns carboxilatos e ânions inorgânicos. O eletrodo foi aplicado com sucesso na determinação de furosemida em medicamentos, urina, soro sanguíneo e amostras comerciais de leite bovino.The construction, evaluation and analytical application of a potentiometric sensor, namely, PtHgHg 2 (Fur) 2 Graphite, where Fur stands for 4-chloro-N-furfuryl-5-sulphamoyl-anthranilate ion, are described. This electrode has a linear dynamic range between 5.0 × 10 -7 -1.0 × 10 -2 mol L -1 with a near-Nernstian slope of (-58.4± 0.9) mV decade -1 and a detection limit of 3.8 × 10 -7 mol L -1 . The potentiometric response is independent of the pH of the solution in the pH range 7.0-9.0. The electrode shows easy construction, low-cost, fast response time (within 10-20 s) and can be used for a period of 6 months without significant change in its performance characteristics. The proposed sensor displayed good selectivities over a variety of other anions (carboxylates and inorganic anions). Application of this potentiometric sensor for the furosemide determination in pharmaceuticals, urine, blood serum and commercial milk samples is reported.Keywords: 4-cloro-N-furfuryl-5-sulphamoylanthranilate-sensitive electrode, potentiometry, pharmaceuticals, urine, human blood serum, bovine milk IntroductionFurosemide or frusemide (HFur, 4-chloro-N-furfuryl-5-sulphamoyl-anthranilic acid) is formally a sulfonamide, an antibacterial agent (Figure 1). However, the intense and fast dieresis produced by this drug has extended its application as a powerful acidic diuretic for diverse treatments in humans and veterinary medicine. Furosemide is often classified as a loop diuretic due to its predominant action in the nephron, where the drug interferes with the tubular re-absorption of sodium on Henle's loop. 1 The renal excretion of ions is not limited to sodium and chloride, but it may also influence potassium, magnesium, calcium and, to a lesser extent, hydrogen carbonate ions. 2 In the clinical practice, the effects of furosemide are applied in the treatment of edema associated with pulmonary, cardiac, hepatic and renal disease, and of hypertension accompanied by fluid retention or impaired renal failure. 3-7 A marked diuresis is also associated to loss of weight, a side effect that has been incorrectly abused in the sport practice to achieve acute weight ...

show abstract

Section: Analytical Applicationmentioning

confidence: 99%

Section: Analytical Applicationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potentiometric sensor for furosemide determination in pharmaceuticals, urine, blood serum and bovine milk

Santini¹,

Pezza²,

Sequinel³

et al. 2009

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

show abstract

Section: Analytical Applicationmentioning

confidence: 99%

“…47 In humans, FFA is mainly metabolized into acyl glucuronides. [48][49][50] Taking into account the role of the flufenamate ion in the electrode response, along with the very low concentration of glucuronides in serum, 49,50 no interference from these metabolites is expected in the determination of FFA in human blood serum by the proposed electrode.Experiments were performed to determine the feasibility of using the flufenamate-sensitive electrode for determination of FFA in human serum samples. Serum samples previously spiked with 4, 8, 12, 16 and 20 µg mL -1 of FFA were treated and analyzed as described under "Determination of Flufenamic Acid in Human Serum Samples".…”

mentioning

confidence: 99%

Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses

Santini¹,

Pezza²,

Oliveira³

et al. 2008

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

As características, o desempenho e a aplicação de um eletrodo do tipo Pt Hg Hg 2 (FF) 2 Grafite, FF=íon flufenamato, são descritas. O eletrodo responde a FF com sensibilidade de (-58,6 1,2) mV década -1 no intervalo de 1,0 10 -6 -1,0 10 -2 mol L -1 , a pH 6,0 -9,0 e com um limite de detecção de 7,1 10 -7 mol L -1 . O eletrodo é de custo relativamente baixo e facilmente construído, apresenta um rápido tempo de resposta (10-25 s) e pode ser usado por um período de 5 meses sem qualquer variação considerável nas suas características de desempenho. O eletrodo proposto mostrou boa seletividade para o íon flufenamato na presença de várias substâncias, bem como na presença de alguns carboxilatos e ânions inorgânicos. O eletrodo foi aplicado com sucesso na determinação de ácido flufenâmico em medicamentos e amostras de soro humano.The characteristics, performance, and application of an electrode, namely, Pt Hg Hg 2 (FF) 2 Graphite, where FF stands for flufenamate ion, are described. This electrode responds to FF with sensitivity of (-58.6 1.2) mV decade -1 over the range 1.0 10 -6 -1.0 10 -2 mol L -1 at pH 6.0 -9.0 and a detection limit of 7.1 10 -7 mol L -1. The electrode is easily constructed at a relatively low cost with fast response time (within 10-25 s) and can be used for a period of 5 months without any considerable change in its performance characteristics. The proposed electrode displayed good selectivity for flufenamate in the presence of several substances as well as in the presence of some carboxylate and inorganic anions. The electrode was successfully applied to the determination of flufenamic acid in pharmaceuticals and human serum samples.Keywords: flufenamate-sensitive electrode, potentiometry, dosage forms, blood serum IntroductionFlufenamic acid (FFA), [N-( , , -trifluoro-m-tolyl) anthranilic acid] is an analgesic, anti-inflammatory and antipyretic drug. It is extensively used in the treatment of arthritis and other illnesses related to muscular-skeletal problems.1 However the use of this drug has been implicated in some cases of nephrotoxicity.2 Due to the importance of the assay of FFA for pharmaceutical formulations and biological fluids, several analytical methods have been developed for the quantitative determination of this drug in both pharmaceutical and biological samples.These methods include spectrophotometry, 21,22 However, many of these methods are often time-consuming, technically demanding and require the use of costly, highly specialized instruments. Thus, there is an important demand for simple, low-cost, sensitive and rapid alternative methods for the determination of FFA in pharmaceuticals and biological fluids.Potentiometric methods with ion-selective electrodes (ISE's) have proved to be effective for the analysis of pharmaceutical formulations and biological samples, because these sensors offer the advantages of simple design, construction, and manipulation, reasonable selectivity, fast response time, applicability to colored and turbid solutions and possible interfacing with au...

show abstract

Terbium‐sensitized fluorescence method for the determination of deferasirox in biological fluids and tablet formulation

et al. 2011

View full text Add to dashboard Cite

A novel, rapid and sensitive spectroflurimetric method was developed and validated for the determination of deferasirox in urine, serum and tablet samples based on sensitization of terbium fluorescence. The excitation and emission wavelengths were 328 and 545 nm, respectively. The optimum conditions for the determination of deferasirox were investigated considering the effects of various parameters. The method was quantitatively evaluated in terms of linearity, recovery, reproducibility and limit of detection. Under the optimal conditions, the fluorescence intensities were linear with the concentration of deferasirox in the range of 5 ¥ 10 -9 to 5¥10 -6 mol L -1, with a detection limit of 1.5 ¥ 10 -9 mol L -1 and a relative standard deviation of 1.1-2.3%. Linearity, reproducibility, recovery and limit of detection made the method suitable for determination of deferasirox in urine, serum and tablets samples.

show abstract

Spectrofluorimetric determination of anthranilic acid derivatives based on terbium sensitized fluorescence

Cited by 65 publications

References 28 publications

Potentiometric sensor for furosemide determination in pharmaceuticals, urine, blood serum and bovine milk

Potentiometric sensor for furosemide determination in pharmaceuticals, urine, blood serum and bovine milk

Development of a potentiometric flufenamate ISE and its application to pharmaceutical and clinical analyses

Terbium‐sensitized fluorescence method for the determination of deferasirox in biological fluids and tablet formulation

Contact Info

Product

Resources

About