Spectrofluorimetric determination of melatonin in kernels of four different Pistacia varieties after ultrasound-assisted solid–liquid extraction

Oladi, Elham; Mohamadi, Maryam; Shamspur, Tayebeh; Mostafavi, Ali

doi:10.1016/j.saa.2014.05.010

Cited by 62 publications

(38 citation statements)

References 18 publications

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“…However, the content of melatonin in foods exhibits huge differences from species to species. Much higher melatonin was observed in nuts and medical herbs [28,29]. For the same species, it varies in different cultivars [30].…”

Section: Dietary Sources Of Melatoninmentioning

confidence: 99%

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Dietary Sources and Bioactivities of Melatonin

et al. 2017

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Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.

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Section: Dietary Sources Of Melatoninmentioning

confidence: 99%

“…Melatonin was found in various nuts, and pistachio ( Pistacia vera L.) was reported with the highest content (233,000 ng/g DW) to date [28]. …”

Section: Dietary Sources Of Melatoninmentioning

confidence: 99%

Dietary Sources and Bioactivities of Melatonin

et al. 2017

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“…Melatonin is an ubiquitous molecule, which has been found not only in the human pineal gland but also in vegetables and their fruits and seeds, medicinal herbs, and fermented products such as nuts, tomatoes, beetroots, cucumber, banana, strawberry, cherry, apple, walnut, pistachio, bread, cocoa powder, green coffee, mustard seeds, feverfew, St John’s Wort, olive oil, wine, beer, etc., at concentrations varying between 5 pg/g or mL to 230 µg/g or mL [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29]. According to the 2011 EFSA Comprehensive European Food Consumption Database (France, Germany, United Kingdom, Spain and Italy) [30], the mean intake of melatonin from the consumption of just twelve food items (tomato, beetroot, banana, strawberry, cherry, apple, walnut, pistachio, bread, olive oil, wine, and beer) ranges between 4 and 550 µg/day, with the United Kingdom and Spain being the countries with the lowest and highest intake of melatonin, respectively.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of VEGF-Induced VEGFR-2 Activation and HUVEC Migration by Melatonin and Other Bioactive Indolic Compounds

et al. 2017

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Excessive concentrations of vascular endothelial growth factor (VEGF) trigger angiogenesis, which causes complications such as the destabilization of atherosclerotic plaques and increased growth of tumors. This work focuses on the determination of the inhibitory activity of melatonin and other indolic related compounds on VEGF-induced VEGF receptor-2 (VEGFR-2) activation and an approximation to the molecular mechanism underlying the inhibition. Quantification of phosphorylated VEGFR-2 was measured by ELISA. Migration wound-healing assay was used to determine cell migration of human umbilical vein endothelial cells (HUVECs). This is the first time that melatonin, 3-indolacetic acid, 5-hydroxytryptophol, and serotonin are proved to significantly inhibit VEGF-induced VEGFR-2 activation in human umbilical vein endothelial cells and subsequent angiogenesis. 3-Indolacetic acid showed the highest inhibitory effect (IC50 value of 0.9704 mM), followed by 5-hydroxytryptophol (35% of inhibition at 0.1 mM), melatonin (30% of inhibition at 1 mM), and serotonin (24% of inhibition at 1 mM). An approximation to the molecular mechanism of the inhibition has been proposed, suggesting that indolic compounds might interact with the cell surface components of the endothelial membrane in a way that prevents VEGF from activating the receptor. Additionally, wound-healing assay revealed that exposure of HUVECs to melatonin and 3-indolacetic acid in the presence of VEGF significantly inhibited cell migration by 87% and 99%, respectively, after 24 h. These data demonstrate that melatonin, 3-indolacetic acid, 5-hydroxytryptophol, and serotonin would be good molecules for future exploitation as anti-VEGF signaling agents.

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“…The factors considered were the composition of the extraction solvent (X 1 ; 0-50% methanol in water), temperature (X 2 ; 10-70°C), amplitude (X 3 ; 30-70%), cycle (X 4 ; 0.2-0.7 s À1 ), solvent pH (X 5 ; 3-7) and solvent-solid ratio (X 6 ; 2.5:1-5:1). Values for the extraction variables were established based on previous information found in the revised literatures about extraction of melatonin [5,[12][13][14]. Since the variables have different units and ranges, each of the variables was first normalized and forced to fall in the range from À1 to +1 in order to obtain a more even response [15].…”

Section: Development Of the Uae Methodsmentioning

confidence: 99%