Spectrophotometric and liquid chromatographic determination of fenofibrate and vinpocetine and their hydrolysis products

El‐Gindy, Alaa; Emara, Samy; Mesbah, Mostafa K.; Hadad, Ghada M.

doi:10.1016/j.farmac.2005.01.013

Cited by 41 publications

(17 citation statements)

References 21 publications

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“…In fact, some enantioselective methods for antidepressants by HPLC or nano-LC report the use of CSPs containing carbohydrates in one form or another (such as cellulose and amylose) [53][54][55] (Cannazza, G. et al, J. Pharmazeut. Biomed., submitted) or of carbohydrates as mobile phase additives [56] and some use a vancomycinmodified stationary phase [57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Electrodriven methods for the enantioseparation of second‐generation antidepressant drugs: An update

Mandrioli

Raggi

2007

Electrophoresis

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Second-generation antidepressant drugs are increasingly prescribed world-wide by psychiatrists and primary care physicians. Generally speaking, they seem to be safer than traditional tricyclic antidepressant drugs, especially in overdose. However, most of them possess stereogenic centers, thus they can exist as enantiomeric couples. Since enantiomers can have even dramatically different pharmacokinetic and pharmacodynamic properties, the study of antidepressant chirality is of great importance. In fact, the application of enantioselective analytical techniques can be useful both for the quality control of enantiomerically pure formulations and for the pharmacovigilance and therapeutic monitoring of patients undergoing treatment with these drugs. The high efficiency and inexpensiveness of electrodriven methods makes them a very attractive alternative to the usual chromatographic methods. This review is an update (2004-2007) of a previously published paper on recent electrodriven methods for the enantioseparation of second-generation antidepressants. In particular, the focus has been put on selective serotonin reuptake inhibitors such as citalopram and sertraline, noradrenergic and specific serotonergic antidepressants, such as mirtazapine and tetracyclic antidepressants such as mianserin, as well as on multianalyte methods.

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Section: Discussionmentioning

confidence: 99%

Electrodriven methods for the enantioseparation of second‐generation antidepressant drugs: An update

Mandrioli

Raggi

2007

Electrophoresis

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“…HPLC was used for the assay of SL with troventol [11], ipratropium bromide, fenoterol and terbutaline [12]. Ternary mixture of AC with phenobarbitone and papaverine hydrochloride was determined using second derivative of the ratio spectrum-zero-crossing and HPLC methods [13]. BX was determined using absorption spectrophotometry and PLS multivariate calibration [14,15].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs

El‐Gindy

Emara

Shaaban

2007

Journal of Pharmaceutical and Biomedical Analysis

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“…13 C NMR spectra of fenofibrate and its degraded products in (Figures 3(a) & 3(b)) show identical carbon peaks except in the degraded product there is a complete disappearance of carbon peaks at δ 21.52 and at 69.34 corresponding to the aliphatic carbon of the two methyl groups of [-O-CH-(CH 3 ) 2 ] and the methine carbon of [-O-CH-(CH 3 ) 2 ], respectively. And this is considered as a further confirmation of the removal of the isopropyl moiety.…”

Section: Identification Of the Degradation Productmentioning

confidence: 99%

“…Fenofibrate was assayed in British Pharmacopeia (BP) by a liquid chromatography method [1]. However, several chromatographic methods have been Fenofibrate reported for the determination of fenofibrate, in pharmaceutical formulations and or in biological fluids, including HPLC [3][4][5][6][7][8][9][10][11], stability indicating HPLC method for simultaneous determination of fenofibrate with other drugs from their combination products [12,13], LC-MS [14][15][16][17], and capillary electrophoresis [18,19]. In addition, there are other methods reported for the determination of fenofibrate, including voltammetry, polarography [20,21], and derivative spectrophotometry [22].…”

Section: Introductionmentioning

confidence: 99%

Determination of Fenofibrate and the Degradation Product Using Simultaneous UV-Derivative Spectrometric Method and HPLC

Salamaa¹,

Nassar²,

El-Din³

et al. 2011

AJAC

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Two new selective, precise, and accurate methods were developed for the determination of fenofibrate in the presence of its basic degradation product. In the first method fenofibrate was determined using an algorithm bivariate calibration derivative method, in which an optimum pair of wavelengths was chosen for the determination of different binary mixtures. In the second method (HPLC), separation was achieved on RESTEK Pinnacle II phenyl column (5 µm, 250 × 4.6 mm) and Pinnacle II phenyl (5 µm, 10 × 4 mm) guard cartridge using a mobile phase consisting of methanol -0.1% phosphoric acid (60:40, v/v) at a flow rate 2 mL·min -1 , and the column oven temperature was set at 50˚C. The UV detector was time programmed at 302 nm and 289 nm for the internal standard (I.S.) and fenofibrate, respectively. The proposed methods were successfully applied for the determination of fenofibrate and its degradation product in the laboratory-prepared mixture and in pharmaceutical formulation. The assay results obtained using the bivariate method were statistically compared to those of the HPLC method and good agreement was observed.

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Spectrophotometric and liquid chromatographic determination of fenofibrate and vinpocetine and their hydrolysis products

Cited by 41 publications

References 21 publications

Electrodriven methods for the enantioseparation of second‐generation antidepressant drugs: An update

Electrodriven methods for the enantioseparation of second‐generation antidepressant drugs: An update

Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs

Determination of Fenofibrate and the Degradation Product Using Simultaneous UV-Derivative Spectrometric Method and HPLC

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