Spectrophotometric and pH-metric studies on Pb(II), Cd(II), Al(III) and Cu(II) complexes of paracetamol and ascorbic acid

Abstract

Spectrophotometric and pH-metric studies of the aqueous binary and mixed ligand complexes of Pb(II), Cd(II), Al(III) and Cu(II) were carried out with ascorbic acid and paracetamol. The study was conducted at an ionic strength of 0.15 mol dm -3 and a temperature of 37.0 ± 0.2 o C. The protonation constants of the free ligands and the stability constants of the binary and mixed ligand complexes were determined using pH titration data. Proton dissociation of free ligands and complex formation were also qualitatively confirmed with UV data. The stabilities of mixed ligand complexes were quantitatively compared with those of the corresponding single ligand complexes in terms of ∆log K. Aluminium formed the most stable binary complex; Al (paracetamol) 2 , with a high overall stability constant (log β 2 = 16.74). The stable mixed ligand complexes; Pb (ascorbic acid) (paracetamol), Cd (ascorbic acid)(paracetamol) and Cu (ascorbic acid) (paracetamol) were observed with positive ∆log K values showing the ability of using them in less harmful chelation therapy of these metals. Further, the results revealed that the bioavailability of both ligands will be lower for a metal intoxicated person.

Ciprofloxacin Release and Corrosion Behaviour of a Hybrid PEO/PCL Coating on Mg3Zn0.4Ca Alloy

“…In this work, this effect could be associated with the formation of insoluble chelates such as Mg/Ca-CIP o [ 19 ] ( Figure S3 ) that could precipitate in the cracks and pores of the PEO coating blocking the access of the corrosive species of the medium. The complexation of these compounds is predicted to be thermodynamically favourable at neutral pH as it was reported in works of pharmacokinetics of the fluoroquinolone group to which CIP belongs [ 12 , 32 ].…”

A rapid on-site analysis method for the simultaneous extraction and determination of Pb2+ and Cd2+ in cereals

“…In addition, VC can also reduce some highvalence metal ions to reduce the interference in the determination. 29 Besides, VC is an organic acid, which is benecial to the reaction of KI and ions. Therefore, different concentrations of VC solution were added.…”

Conductometric, Spectrophotometric and Computational Investigation of Binary and Ternary Complexes of Co(II) and Cu(II) Bivalent Metal Ions with L-Valine Amino Acid and Paracetamol Drug

“…Thus, the present paper deals with the determination of the formation constants and the binding ratio of the binary and ternary complexes formed by Co(II) and Cu(II) with L-Val and Para using the conductometric and the spectrophotometric methods at (40 ± 0.1 °C) temperature. The method of conductometric (20, 21) as adopted by the direct conductivity method has been employed to determine K values, while the spectrophotometric using the continuous variation method has been employed to determine K values and binding ratio for the binary ligands-metal complexes (21)(22)(23).…”