Spectrophotometric and spectrofluorometric methods for the assay of lisinopril in single and multicomponent pharmaceutical dosage forms

El‐Yazbi, Fawzy A.; Abdine, H.; Shaalan, Rasha A.

doi:10.1016/s0731-7085(98)00110-1

Cited by 48 publications

(37 citation statements)

References 5 publications

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“…There are numerous methods available for lisinopril analysis in single component or multi component formulation using spectrophotometry [2][3][4], gas-liquid chromatography [5] capillary electrophoresis and polarography [6,7]. Several High pressure liquid chromatography HPLC methods have been used for the analysis of lisinopril in human plasma [8][9][10].…”

Section: Reported Methods Of Analysismentioning

confidence: 99%

“…Enalapril maleate has been simultaneously determined with hydrochlorothiazide and furosemide commonly used diuretics [23], commonly used NSAIDs [24], anti diabetic drugs [25], cholesterol lowering agent statins [26] and with metformin, glibenclamide and glimepride [27] in bulk material, pharmaceutical formulations and human serum using RP-HPLC. Spectrophotometric methods after derivatization of lisinopril and other techniques has been describe previously [3,6,[28][29][30][31][32][33].…”

Section: Reported Methods Of Analysismentioning

confidence: 99%

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Analytical Determination of Lisinopril Using UV Spectrophotometer and HPLC: An Overview

Sattar¹

2014

Mod Chem Appl

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Present review article determine the analytical methods for the quantitative determinations of lisinopril (ACE Inhibitor) by UV spectrophotometery and High-Performance Liquid chromatography. Pharmaceutical analysis of lisinopril requires effective analytical procedures for QC quality control analysis in Pharmaceuticals dosage formulations and human serum. An extensive survey for determination of LSP compiled from the research articles published in various pharmaceutical and analytical chemistry Journals. This appraisal illustrate that majority of the HPLC methods reviewed are based on the quantitative analysis of drug in Active Pharmaceutical ingredients (API), formulations, biological fluids such as serum and plasma and they are appropriate for therapeutic monitoring of drug, for pharmacokinetic purpose.

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Section: Reported Methods Of Analysismentioning

confidence: 99%

Section: Reported Methods Of Analysismentioning

confidence: 99%

Analytical Determination of Lisinopril Using UV Spectrophotometer and HPLC: An Overview

Sattar¹

2014

Mod Chem Appl

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“…Enalapril maleate has been assayed by spectrophotometric [3][4][5][6][7], potentiometric [8,9], HPLC [10][11][12][13][14] and 1 H-NMR [15] methods. In tablets, lisinopril dihydrate has been determined by GC [16,17], spectrophotometric [18][19][20][21], colorimetric and fluorimetric [17] procedures. Capillary electrophoresis has been used to separate closely related ACE inhibitors and to quantities them in their pharmaceutical preparations [22,23] and stripping voltammetric method [24].…”

Section: Lisinopril (S)-1-[n-[1-(ethoxycarbonyl)-3 Phenylpropy1]-l-mentioning

confidence: 99%

New Method for Spectrophotometric Determination of Lisinopril in Pure Form and in Pharmaceutical Formulations

Shraitah¹,

Okdeh²

2016

Mod Chem Appl

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An accurate, simple, fast and cheap spectrophotometric method has been developed for the determination of lisinopril in pharmaceutical pure and dosage forms. The method is based on the reaction of Alizarin with primary amine present in the lisinopril in the presence of 80% ethyl alcohol. This reaction produces a complex Red colored product which absorbs maximally at 434 nm. Beer's law was obeyed in the range of 4.415-300.23 µg/mL with molar absorptivity of 1.619 × 10 3 L mole -1 cm -1 Sandell's sensitivity 0.272 µg.cm -2 . The effects of variables such as temperature, heating time, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were Pharmaceutical formulations..

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“…10 The results obtained were compared statistically by the student's t-test and variance ratio F-test (Table 7). The experimental t-and F-values did not exceed the theoretical ones at 95% confidence level, indicating the absence of any significant difference between the compared methods.…”

Section: Optimization Of Reaction Variablesmentioning

confidence: 99%

“…Chem. Soc. with sodium hypochlorite and phenylhydrazine, 2 chloranil, 10 dichlone, 10 acetylacetone and formaldehyde, 10 1,2-napthoquinone-4-sulphonic acid, 11 2,4,6-trinitro-benzoic acid, 12 2,4-dinitroflurobenzene 13 and 7-chloro-4-nitrobenzo-2-oxa-1, 3-diazole. 14 Panzade and co-workers 15 have reported a UV spectrophotometric method for the quantification of lisinopril at 205 nm.…”

Section: Introductionmentioning

confidence: 99%

Optimized and validated spectrophotometric methods for the determination of lisinopril in pharmaceutical formulations using ninhydrin and ascorbic acid

Rahman¹,

Singh²,

Hoda

2005

J. Braz. Chem. Soc.

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Dois métodos espectrofotométricos, simples e sensíveis, são descritos para a determinação de lisinoprila pura e em preparações farmacêutica. O primeiro método é baseado na reação da droga com nihidrina, no solvente N, N'-dimetilformamida (DMF) a temperatura ambiente, a qual é acompanhada espectrofotometricamente pela medida do aumento da absorbância a 595 nm, em função do tempo. As técnicas de medida da velocidade inicial, da determinação da constante de velocidade e de medida em tempo fixo (10 min) foram adotadas na construção das curvas de calibração, para a determinação da concentração da droga. Os métodos de velocidade inicial e da medida em tempo fixo mostraram uma resposta linear no intervalo de concentração 10-50 μg mL -1 , enquanto o método de constante de velocidade tem resposta linear no intervalo 10-40 μg mL -1 . No segundo método, a droga reage com ácido ascórbico em solução de DMF, resultando num produto colorido com máximo de absorbância a 530 nm. A lei de Beer é obedecida no intervalo de concentração 5-50 μg mL -1 de linisoprila, com absortividade molar de 4,548×10 3 L mol -1 cm -1 . As variáveis que afetam o desenvolvimento da cor foram otimizadas, e o método foi validado estatisticamente e por estudos de recuperação. O método proposto foi usado com sucesso na determinação de lisinoprila em comprimidos comerciais.Two simple and sensitive spectrophotometric methods are described for the determination of lisinopril in pure form and pharmaceutical preparations. The first method is based on the reaction of the drug with ninhydrin in N,N'-dimethylformamide (DMF) medium at room temperature which is followed spectrophotometrically by measuring the increase in absorbance at 595 nm as a function of time. The initial-rate, rate-constant and fixed-time (at 10 minutes) procedures were used for constructing the calibration graphs to determine the concentration of the drug. The initial-rate and fixed-time procedures showed a linear response over the concentration range 10-50 μg mL -1 whereas rate-constant procedure was applicable in the range 10-40 μg mL -1 . In the second method, the drug reacts with ascorbic acid in DMF medium resulting in the formation of a coloured product, which absorbed maximally at 530 nm. Beer's law is obeyed in the concentration 5-50 μg mL -1 of lisinopril with molar absorptivity of 4.548×10 3 L mol -1 cm -1 . The variables affecting the development of the colour are optimized and the developed methods are validated statistically and through recovery studies. The proposed methods have been successfully applied to the determination of lisinopril in commercial tablets.Keyword: lisinopril, ninhydrin, ascorbic acid, dimethylformamideis an angiotensin converting enzyme (ACE) inhibitor. It is used in the treatment of hypertension and heart failure. The increasing use of this recently introduced drug, which is highly susceptible to the acidic degradation, needs simple, sensitive and selective method for the routine analysis in pharmaceutical formulations.Certain successful attempts have been...

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Spectrophotometric and spectrofluorometric methods for the assay of lisinopril in single and multicomponent pharmaceutical dosage forms

Cited by 48 publications

References 5 publications

Analytical Determination of Lisinopril Using UV Spectrophotometer and HPLC: An Overview

Analytical Determination of Lisinopril Using UV Spectrophotometer and HPLC: An Overview

New Method for Spectrophotometric Determination of Lisinopril in Pure Form and in Pharmaceutical Formulations

Optimized and validated spectrophotometric methods for the determination of lisinopril in pharmaceutical formulations using ninhydrin and ascorbic acid

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