Spectrophotometric cocaine determination in a biphasic medium employing flow-batch sequential injection analysis

Silva, Maria José da; Anjos, Edijane V. dos; Honorato, Ricardo S.; Pimentel, Maria Fernanda; Paim, Ana Paula S.

doi:10.1016/j.aca.2008.09.030

Cited by 22 publications

(28 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To overcome this drawback, the flow system module was re-designed to use the flow-batch approach. 29,34,35 The open chamber and the efficient mixing obtained using a mini-motor removed the gas bubbles from the bulk of the sample solution in the reaction chamber.…”

Section: Resultsmentioning

confidence: 99%

A multicommuted flow analysis method for the photometric determination of amoxicillin in pharmaceutical formulations using a diazo coupling reaction

Freitas¹,

Silva²,

Araújo³

et al. 2011

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Neste trabalho foi proposto um método de análise em fluxo por multicomutação para a determinação de amoxicilina em formulações farmacêuticas. O método proposto é baseado na reação de diazotização da o-nitroanilina com amoxicilina em meio alcalino, produzindo um composto amarelo que foi monitorado em 435 nm. As características do método foram: faixa linear de 25 até 400 mg L -1 de amoxicilina, limite de detecção de 5,1 mg L -1 , frequência analítica de 50 determinações por hora e desvio padrão relativo inferior a 3,9% (n = 10) para uma amostra típica de 100 mg L -1 amoxicilina. Para verificar a exatidão do método, as amostras foram analisadas empregando um método independente e aplicando-se o teste-t pareado não houve diferença significativa no nível de confiança de 95%.A multicommuted flow analysis method for the spectrophotometric determination of amoxicillin in pharmaceutical formulations is reported. The proposed method is based on the reaction of diazotised o-nitroaniline with amoxicillin in an alkaline medium, producing a yellow compound that was monitored at 435 nm. The main features of the method were: a linear relationship with amoxicillin concentration ranging from 25 to 400 mg L -1 ; a detection limit of 5.1 mg L -1; an analytical throughput of 50 determinations per hour; and a relative standard deviation lower than 3.9% for a typical amoxicillin sample with concentration of 100 mg L -1 (n = 10). To verify the accuracy of the method, samples were also analyzed employing an independent method, and applying the paired t-test to the results no significant difference at the 95% confidence level was observed.

show abstract

Section: Resultsmentioning

confidence: 99%

A multicommuted flow analysis method for the photometric determination of amoxicillin in pharmaceutical formulations using a diazo coupling reaction

Freitas¹,

Silva²,

Araújo³

et al. 2011

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…69 Um único trabalho tem foco em análise forense, visando a determinação do teor de cocaína em amostras apreendidas pela polícia, o que permite traçar possíveis rotas de tráfico. 70 Dois artigos tratam da determinação de espécies em urina: o primeiro 39 descreve a quantificação de Pd e o segundo, de compostos de arsênio 76 (é também o único a empregar o sistema de ICP-MS para a confirmação das espécies estudadas).…”

Section: Características E Operaçãounclassified

A análise por injeção sequencial (SIA): vinte anos em uma perspectiva brasileira

Santos¹,

Masini²

2010

Quím. Nova

View full text Add to dashboard Cite

“…The FCFM have already found applications for the automation of analysis of aqueous samples [110][111][112], biological fluids [113], pharmaceuticals [114], biofuels [115,116] and other samples ( Table 2) Thus, the liquid-liquid extraction of analytes can be realized directly in the MCh for the pre-concentration [117]. In this case, the effective mixing of the aqueous and organic phases, as well as the phases separation, are carried out in the glass MCh.…”

Section: Recent Development and Applicationmentioning

confidence: 99%

Flow Analysis: A Novel Approach For Classification

Vakh

Falkova

Timofeeva

et al. 2016

Critical Reviews in Analytical Chemistry

View full text Add to dashboard Cite

show abstract

Spectrophotometric cocaine determination in a biphasic medium employing flow-batch sequential injection analysis

Cited by 22 publications

References 37 publications

A multicommuted flow analysis method for the photometric determination of amoxicillin in pharmaceutical formulations using a diazo coupling reaction

A multicommuted flow analysis method for the photometric determination of amoxicillin in pharmaceutical formulations using a diazo coupling reaction

A análise por injeção sequencial (SIA): vinte anos em uma perspectiva brasileira

Flow Analysis: A Novel Approach For Classification

Contact Info

Product

Resources

About