Spectrophotometric determination of antiplasmodial cochloxanthins from roots of Cochlospermum planchonii Hook.f. (Bixaceae)

Bragagna, Laura; Coulibaly, Maminata Traoré; Stolze, Klaus; Ouédraogo, Jean Claude W.; Yougbaré, Sibidou; Dakuyo, Z.; Novak, Johannes

doi:10.1016/j.sciaf.2019.e00055

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Rare carotenoids with 6‐hydroxy‐3‐keto‐ε‐end group (Fig. 1 inset), including piprixanthin, vitixanthin, or cochloxanthin, have been identified in manakin birds [2,3] and plants such as Cochlospermum vitifolium [4] or Cochlospermum planchonii [5]. Interestingly, the same 6‐hydroxy‐3‐keto‐ε‐end group structure is also shared in plant or fungi hormone apocarotenoids such as abscisic acid [6] or blumenol [7] (Fig.…”

Section: Figmentioning

confidence: 99%

Promiscuous activity of β‐carotene hydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6‐hydroxy‐3‐keto‐ε‐ends

2022

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Carotenoids with rare 6‐hydroxy‐3‐keto‐ε‐end groups, such as piprixanthin, vitixanthin, or cochloxanthin, found in manakin birds or plants, are rare carotenoids with high antioxidant activity. The same chemical structure is found in abscisic acid or blumenol, apocarotenoids found in plants or fungi. In this study, we serendipitously discovered that the promiscuous activity of the β‐carotene hydroxylase CrtZ, a diiron‐containing membrane protein, can catalyze the formation of 6‐hydroxy‐3‐keto‐ε‐end by using epoxycarotenoids antheraxanthin or violaxanthin as substrate. We suggest that the reaction mechanism is similar to that of a rhodoxanthin biosynthetic enzyme. Our results provide a further understanding of the reaction mechanism of diiron‐containing β‐carotene hydroxylases, as well as insight into the biosynthesis of natural compounds with 6‐hydroxy‐3‐keto‐ε‐end carotenoid derivatives.

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Section: Figmentioning

confidence: 99%

Promiscuous activity of β‐carotene hydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6‐hydroxy‐3‐keto‐ε‐ends

2022

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“…Furthermore, Diallo et al isolated 3-bisabolen, 2tridecanone, 3-hexadecanone, 1-dodecanol, l-tetradecanol, 2-pentdecanone, 3-octadecanone, 1-hydroxy-3-hexadecanone, 1-nonadecanol, l-O-acetyl-3-hexadecanone, lhydroxy-3-oetadecanone from the rhizome extract of the plant [37]. The main compounds cochloxanthine and dihydrocochloxanthine were isolated from the ethanol rhizome extract of C. tinctorium using high-performance liquid chromatography-ultraviolet (HPLC-UV) [9,38]. The rhizome of the plant was reported to contains carotenoids, phenolic compounds (gallic and ellagic acid) and triacylbenzenes (cochlospermines A, B, C, D) in the non-polar fractions of the plant extract [21].…”

Section: Identified and Isolated Bioactive Compounds From Cochlosperm...mentioning

confidence: 99%

Traditional uses, phytochemistry, and pharmacological activities of Cochlospermum tinctorium A. Rich (Cochlospermaceae): a review

et al. 2021

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Background The plant Cochlospermum tinctorium A. Rich is a sub-shrub that belongs to the family Cochlospermaceae. The plant has been used in traditional medicine for the treatment of malaria, rickets, stomachache, diarrhea, gastric ulcer, parasitic infestations, liver diseases, fever, pain, inflammation, infectious diseases, epilepsy, snake bite, burns, orchitis, labour, menstrual problems, and many other diseases. This review summarizes the traditional uses, phytochemistry, and pharmacological activities of Cochlospermum tinctorium. Main text To date, few bioactive molecules have been identified and isolated from the plant such as 7,3-dimethyldihydroquercelin, 5,4-dimethylquercelin, cochloxanthine, dihydrocochloxanthine, arjunolic acid, 3-O-E-p-coumaroylalphitolic acid, alphitolic acid, 1-hydroxytetradecan-3-one, 3-bisabolen, 2-tridecanone, 3-hexadecanone, 1-dodecanol, l-tetradecanol, 2-pentdecanone, 3-octadecanone, 1-hydroxy-3-hexadecanone, 1-nonadecanol, l-O-acetyl-3-hexadecanone, and l-hydroxy-3-oetadecanone. The literature related some of the reported ethnomedicinal uses of the plant to these compounds found in the different parts of the plant. Conclusion The comprehensive information documented in this review about the importance of the C. tinctorium may provide an opportunity for research advancement in drug discovery and a better understanding of the medicinal benefits of the plant.

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Spectrophotometric determination of antiplasmodial cochloxanthins from roots of Cochlospermum planchonii Hook.f. (Bixaceae)

Cited by 2 publications

References 21 publications

Promiscuous activity of β‐carotene hydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6‐hydroxy‐3‐keto‐ε‐ends

Promiscuous activity of β‐carotene hydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6‐hydroxy‐3‐keto‐ε‐ends

Traditional uses, phytochemistry, and pharmacological activities of Cochlospermum tinctorium A. Rich (Cochlospermaceae): a review

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