Spectrophotometric Determination of Cephapirin, a Cephalosporin Antibacterial

Bodnar, J.E.; Evans, W. G.; Mays, David L.

doi:10.1002/jps.2600660814

Cited by 7 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A. M. J. Barbosa et al 1144 Several analytical procedures are available in the literature for the analysis of cephalosporins via spectrophotometric (Rodenas et al 1997;Bodnar et al 1977;Nabi et al 1997;Martinez et al 1998;Metwally et al 2001;Al-Momani 2001;Morelli 2003), fluorimetric (Hefnawy et al 1999;Bebawy et al 2003), and high performance liquid chromatographic (Abdel-Hamid 1998;Samanidou et al 1998;Manna and Valvo 2004) methods.…”

Section: Introductionmentioning

confidence: 99%

Cathodic Stripping Voltammetry Determination of Ceftiofur Antibiotic in Formulations and Bovine Serum

2006

View full text Add to dashboard Cite

A sensitive and reliable stripping voltammetry method was developed to determine the presence of Ceftiofur antibiotic drug. This method is based on the adsorptive accumulation of the drug at a hanging mercury drop electrode and then the initiation of a negative sweep that yielded well-defined cathodic peaks at 20.65 V (1 C) and 21.00 V (2 C) vs. Ag/AgCl reference electrode. To achieve high sensitivity, various experimental and instrumental variables were investigated such as supporting electrolyte, pH, accumulation time and potential, drug concentration, scan rate, convection rate, and working electrode area. The monitored adsorptive current of peak 1 C was directly proportional to the concentration of Ceftiofur; it shows a linear response in the range from 0.50 Â 10 28 to 8.00 Â 10 28 mol L 21 (correlation coefficient ¼ 0.998); and the limit of detection is 6.00 Â 10 210 mol L 21 at an accumulation time of 300 s. The applicability of this approach was illustrated by the determination of Ceftiofur in pharmaceutical preparations and bovine serum.

show abstract