Spectrophotometric Determination of Chlorpromazine in Pharmaceutical Dosage Forms

Murty, B.S.; Baxter, R.M.

doi:10.1002/jps.2600590721

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Among the methods used for determination of CPZ such as spectrophotometry [7][8][9][10][11], electrochemiluminescence [12], fluorimetric [13], chromatography [14,15], phosphorimetry [5], the electrochemical methods, especially the voltammetric methods [16,17] have received increasing attention, due to their simplicity, rapidity, portability, cost-effectiveness, and sensitivity. Voltammetric sensors based on platinum disk [18], ruthenium [19], alkylthiol/phospholipid-modified gold electrode [20], graphene paste electrode [21] and multiwalled carbon nanotube-polyethyleneimine (MWCNT-PEI) composite modified GCE [17] have been reported.…”

Section: Introductionmentioning

confidence: 99%

Determination of Chlorpromazine Hydrochloride with a Layered Double Hydroxide Modified Glassy Carbon Electrode as a Nanocatalyst

et al. 2020

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We report a simple and sensitive voltammetric sensor for the determination of chlorpromazine (CPZ) based on Ni−Al layered double hydroxide (NiAlLDH) modified glassy carbon electrode (GCE). NiAlLDH was simply electrodeposited on GCE surface in a very short time. The response linear range was 1×10−3–1×10−9 mol L−1, with a detection limit of 1×10−9 mol L−1. The NiAlLDH film showed well defined and well separate peaks for dopamine, ascorbic acid, uric acid and CPZ in the same solution. The proposed electrode was used to measure the active pharmaceutical ingredient of CPZ tablet as a real sample.

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Section: Introductionmentioning

confidence: 99%

Determination of Chlorpromazine Hydrochloride with a Layered Double Hydroxide Modified Glassy Carbon Electrode as a Nanocatalyst

et al. 2020

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“…The literature survey revels that there are verity of analytical method for the quantification of THP, TFP and CLP from mono formulation or from biological matrix. The available methods for quantification of THP from formulation or from biological samples are based on LC-MS 5 , GC 6 , Capillary zone electrophoresis [7][8] , HPLC with UV detector 9 , UV-spectroscopy 10 and TLC and for quantification 11 of TFP from formulation or from biological samples are based on LC-MS 12 , HPLC with UV detector [13][14][15][16] , UV-spectroscopy 15,[17][18][19] , TLC 15,20 , GC-MS 21 , voltametric 22 and Fluorimetric 23 , however for quantification of CLP from formulation or from biological samples are based on LC-MS [24][25] , HPLC with UV detector [26][27][28][29][30][31][32] , UV-spectroscopy [33][34][35] , GC-MS 36,37 , TLC 38 , Potentiometer [39][40][41] , NMR 42 , Radioimmunoassay 43 , Fluorimetry 44 , Chemiluminescence 45 , Electron spin resonance spectroscopy 46 .…”

Section: Introductionmentioning

confidence: 99%

Stability Indicating HPLC Method for Simultaneous Quantification of Trihexyphenidyl Hydrochloride, Trifluoperazine Hydrochloride and Chlorpromazine Hydrochloride from Tablet Formulation

Shetti¹,

Venkatachalam²

2010

Journal of Chemistry

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A new, simple, precise, rapid, selective and stability indicating reversed-phase high performance liquid chromatographic (HPLC) method has been developed and validated for simultaneous quantification of trihexyphenidyl hydrochloride, trifluoperazine hydrochloride and chlorpromazine hydrochloride from combined tablet formulation. The method is based on reverse-phase using C-18 (250×4.6) mm, 5 μm particle size column. The separation is achieved using isocratic elution by methanol and ammonium acetate buffer (1% w/v, pH 6.5) in the ratio of 85:15 v/v, pumped at flow rate 1.0 mL/min and UV detection at 215 nm. The column is maintained at 30 °C through out the analysis. This method gives baseline resolution. The total run time is 15 min. Stability indicating capability is established buy forced degradation experiment. The method is validated for specificity, accuracy, precision and linearity as per International conference of harmonisation (ICH). The method is accurate and linear for quantification of trihexyphenidyl hydrochloride, trifluoperazine hydrochloride and Chlorpromazine hydrochloride between 5 - 15 μg/mL, 12.5- 37.5 μg/mL and 62.5 - 187.5 μg/mL respectively.

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“…6 Various analytical methods have been used for the analysis of the compound in both pharmaceutical dosage forms and biological fluids. Some of the analytical methods that have been employed include thinlayer chromatography 7 , gas liquid chromatography 8 , gas chromatography/mass spectrometry 9 , high performance liquid chromatography 10 -12 , spectroelectrochemical method 13 , spectrophotometry 14 , radioimmunoassay 15, 16 fluorimetry 17 , voltammetry 18 , chemiluminescence method 19 , electron spin resonance spectroscopy 20 , nuclear magnetic resonance (nmr) spectroscopy 21 and flow-injection potentiometric method. 22 Presently, there is an increase in the number of generic drug products from multiple sources and this has placed the pharmacists and other health practitioners in a position of having to select one among several seemingly equivalent products.…”

Section: Introductionmentioning

confidence: 99%

Comparative determination of chlorpromazine hydrochloride content in multi-sourced chlorpromazine tablets in Nigeria

Okeri¹,

Alonge²,

Etareri³

2010

Int J Health Res

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Purpose: Although different brands or unbranded chlorpromazine tablets from multiple sources are available in Nigeria today, they must all contain the same active principle and satisfy the standards of quality, efficacy and safety. This study is designed to check for possible faking and adulteration of chlorpromazine tablets and also establish the possibility of inter-brand substitution based on drug content (chemical equivalence). Method: The determination of the chlorpromazine hydrochloride content was carried using non-aqueous titrimetric and spectrophotometric methods. Glacial acetic acid and acetone were used as the non-aqueous solvent and equivalence points were determined using visual indicators and potentiometer. Results: The results obtained showed that all the brands analyzed met the specification of the British Pharmacopoeia and so contain acceptable amounts of chlorpromazine drug content thus enabling possible brand substitution. Statistical comparison showed no significant difference between the results obtained by determining end-point using visual indicators and the potentiometer. Conclusion: The use of the visual indicator method is recommended for fast and accurate routine laboratory analytical work especially in developing nations.

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Spectrophotometric Determination of Chlorpromazine in Pharmaceutical Dosage Forms

Cited by 4 publications

References 2 publications

Determination of Chlorpromazine Hydrochloride with a Layered Double Hydroxide Modified Glassy Carbon Electrode as a Nanocatalyst

Determination of Chlorpromazine Hydrochloride with a Layered Double Hydroxide Modified Glassy Carbon Electrode as a Nanocatalyst

Stability Indicating HPLC Method for Simultaneous Quantification of Trihexyphenidyl Hydrochloride, Trifluoperazine Hydrochloride and Chlorpromazine Hydrochloride from Tablet Formulation

Comparative determination of chlorpromazine hydrochloride content in multi-sourced chlorpromazine tablets in Nigeria

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