Spectrophotometric determination of diltiazem hydrochloride with sodium metavanadate

Rahman, Nafisur; Azmi, Syed Najmul Hejaz

doi:10.1016/s0026-265x(00)00025-4

Cited by 24 publications

(23 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Various analytical methods have been employed for this purpose, e.g. high-performance liquid chromatography in human cardiac tissue [7], in blood [8] and in human plasma [9][10][11][12][13], high-performance thin-layer chromatographic [14], gas chromatography [15], spectrophotometry [16,17], liquidsolid extraction [18] and voltammetry [19]. Since employed techniques for determination of diltiazem in the presence of other drugs are mostly spectroscopy and HPLC, and these methods often are complex and consuming cost solvents, must easy-handled and simple-operating methods need be applied.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric sensor based on Co3O4/SnO2 nanopowders for determination of diltiazem in tablets and biological fluids

et al. 2016

View full text Add to dashboard Cite

In this work, an anodic stripping voltammetry for nanomolar determination of diltiazem with a chemically modified carbon paste electrode (CMCPE) containing Co 3 O 4 / SnO 2 nanopowders was studied. The accumulation potential and time were selected at, -0.2 V and 190 s, respectively. The electroanalytical performance of the CMCPE was evaluated regarding the carbon paste composition, the solution pH, the time and potential accumulation, and the potential interferences. The novel electrode showed linear response to diltiazem concentration range of 50-650 nM with a lowest detection limit value of 15 nM. The precisions for six consecutive determinations of 350 and 550 nM diltiazem were 3.2 and 2.5 %, respectively. It was demonstrated that the proposed method was free from most interference. Finally, the method was effectively applied to the determination of diltiazem in pharmaceutical tablets and biological samples.

show abstract

Section: Introductionmentioning

confidence: 99%

Voltammetric sensor based on Co3O4/SnO2 nanopowders for determination of diltiazem in tablets and biological fluids

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The assay procedure listed in British Pharmacopoeia [3] and USP (Id acronym at 1 st usage) [4], where in the drug and its formulations are estimated by an HPLC (Id) method. The other methods for its estimation include gas chromatography (GC) [5,6], capillary GC [7], capillary electrophoresis [8], Raman spectroscopy [9], voltammetry and amperometry [10], HPLC [11][12][13][14][15][16][17][18][19][20][21][22][23], colorimetry [24,25], and spectrophotometry [26][27][28][29][30][31][32]. The present work describes the optimization of conditions for the determination of diltiazem hydrochloride in bulk and tablet formulations through oxidation-reduction reactions.…”

Section: Introductionmentioning

confidence: 99%

Indirect spectrophotometric determination of diltiazem hydrochloride in pure form and pharmaceutical formulations

El‐Didamony

2005

Open Chemistry

View full text Add to dashboard Cite

Three simple, accurate, and sensitive spectrophotometric methods (A, B and C) have been described for the indirect assay of diltiazem hydrochloride (DIL.HCl), either in pure form or in pharmaceutical formulations. The first method (A) is based on the oxidation of DIL.HCl by N-bromosuccinimide (NBS) and determination of unconsumed NBS by measuring the decrease in absorbance of amaranth dye (AM) at a suitable λ max = 521 nm. Other methods (B) and (C) involve the addition of excess cerric ammonium sulfate (CAS) and subsequent determination of the unconsumed oxidant by a decrease in the red color of chromotrope 2R (C2R) at a suitable λ max = 528 nm or a decrease in the orange-pink color of rhodamine 6G (Rh6G) at λ max = 525 nm, respectively. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges 3.0 -9.0, 3.5 -7.0 and 3.5 -6.3 µg ml −1 for methods A, B and C, respectively. The apparent molar absorptivity, Sandell's sensitivity, detection and quantification limits were calculated. The proposed methods have been applied successfully for the analysis of the drug in its pure form and its dosage form. No interference was observed from a common pharmaceutical adjuvant. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.

show abstract

“…Calcium channel blockers have been determined by a variety of analytical techniques, such as HPLC [2][3][4][5][6][7][8][9][10], HPTLC [11][12][13][14][15][16], gas chromatography [17][18][19][20][21], Micellar electrokinetic chromatography [22][23][24][25], electroanalytical methods [26][27][28] and spectrophotometric methods [29][30][31][32][33][34].…”

Section: Amlodipine Besylate (Adb)mentioning

confidence: 99%

Spectrophotometric determination of some calcium channel blockers using Sulfochlorophenol-S, Bromopyrogallol red, Eriochromecyanine-R and Pyrocatechoil violet

Omar¹,

Abdelmageed²,

Abdelgaber³

et al. 2013

View full text Add to dashboard Cite

show abstract

Spectrophotometric determination of diltiazem hydrochloride with sodium metavanadate

Cited by 24 publications

References 11 publications

Voltammetric sensor based on Co3O4/SnO2 nanopowders for determination of diltiazem in tablets and biological fluids

Voltammetric sensor based on Co3O4/SnO2 nanopowders for determination of diltiazem in tablets and biological fluids

Indirect spectrophotometric determination of diltiazem hydrochloride in pure form and pharmaceutical formulations

Spectrophotometric determination of some calcium channel blockers using Sulfochlorophenol-S, Bromopyrogallol red, Eriochromecyanine-R and Pyrocatechoil violet

Contact Info

Product

Resources

About